Christopher Rugg

Sex-Specific Effects of Intravenous Anesthetics on the Hemoglobin-Oxygen Dissociation Curve: A Pilot In Vitro Study

Marco Ronzani, Norbert Mair, Simon Woyke, Christoph Frisch et autres

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Inflammation und Hämoglobin-Sauerstoffaffinität

Nikolai Staier, Norbert Mair, Christoph Frisch, Herbert Oberacher et autres

Zusammenfassung Bei septischen Patient:innen ist die Sauerstoffversorgung häufig beeinträchtigt, doch der spezifische Einfluss von Inflammation auf die Sauerstofftransporteigenschaften der Erythrozyten ist weitgehend unerforscht. Diese Studie untersuchte die direkten Effekte von Endotoxin-induzierter Inflammation auf die Sauerstoffbindungskurve (ODC). Akute Lipopolysaccharid(LPS)-induzierte Inflammation veränderte die Hämoglobin-Sauerstoffbindung …

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Inflammation and Hemoglobin Oxygen Affinity

Nikolai Staier, Norbert Mair, Christoph Frisch, Herbert Oberacher et autres

In septic patients, oxygen delivery is often impaired, yet the specific impact of inflammation on erythrocyte oxygen transport characteristics remains largely unexplored. This study examined the direct effects of endotoxin-induced inflammation on the oxygen dissociation curve (ODC) and evaluated dexamethasone and noradrenaline …

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Evaluation of Tracheal Pressure During Invasive CPAP Ventilation

Patrick Spraider, Julia Abram, Janett Kreutziger, Stefan Schmid et autres

Background Intubated but spontaneously breathing patients in the ICU frequently are treated with CPAP ventilation during weaning from mechanical ventilation. However, depending on the patient's inspiratory effort, a pressure gradient along the airway may arise, potentially even leading to negative values at …

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The Urea–Creatinine Ratio as Marker of Catabolism Is Affected by Continuous Renal Replacement Therapy

Andreas Markl-Le Levé, Petra Hillinger, Simon Woyke, Marco Ronzani et autres

Background: An elevated urea–creatinine ratio (UCR) is used as a surrogate for catabolism and elevated protein metabolism in critically ill patients. This study investigated the effect of continuous renal replacement therapy (CRRT) on UCR. Methods: In this retrospective single-centre study, ICU patients …

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The Impact of Protein Feed on the Urea-to-Creatinine Ratio—A Retrospective Single-Center Study

Petra Hillinger, Andreas Markl-Le Levé, Simon Woyke, Marco Ronzani et autres

BACKGROUND/OBJECTIVES: The urea-to-creatinine ratio (UCR) serves as a biochemical marker for catabolism in the intensive care unit (ICU). UCR increases mainly due to an elevated urea generation from increased protein metabolism. This study aimed to evaluate the impact of protein intake on …

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Sex dependent effects of cardiovascular agents on hemoglobin oxygen affinity – An ex-vivo experiment

Simon Woyke, Marco Ronzani, Norbert Mair, K Marcher et autres

Hemoglobin‑oxygen (Hb-O 2 ) affinity is an important determinant for oxygen delivery and oxygen extraction. Although cardiovascular agents such as noradrenaline, adrenaline, atropine, milrinone and levosimendan are widely used in intensive care units worldwide, nothing is known about their possible effects on …

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Organ Utilization From Donors Following Extracorporeal Cardiopulmonary Resuscitation: A Systematic Review of Graft and Recipient Outcome

Saša Rajšić, Benedikt Treml, Christopher Rugg, Nicole Innerhofer et autres

BACKGROUND: The global shortage of solid organs for transplantation is exacerbated by high demand, resulting in organ deficits and steadily growing waiting lists. Diverse strategies have been established to address this issue and enhance organ availability, including the use of organs from …

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Lebensqualität nach innerklinischem Herz-Kreislauf-Stillstand

Benedikt Treml, Christine Eckhardt, Christoph Oberleitner, Thomas Ploner et autres

BACKGROUND: Cardiac arrest is a life-threatening condition requiring urgent medical care and is one of the leading causes of death worldwide. Given that in-hospital cardiac arrest (IHCA) is still poorly investigated, data on health-associated quality of life thereafter remains scarce. The available …

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The impact of cannabinoids on methemoglobin formation and hemoglobin oxygen affinity: An ex-vivo study

Simon Woyke, Norbert Mair, Thomas Haller, Marco Ronzani et autres

The affinity of hemoglobin (Hb) to oxygen (O2) influences processes of oxygen delivery and extraction at the tissue level. Despite cannabinoids being utilized or ingested in various ways, their possible impact on Hb-O2 affinity has barely been studied. This is an experimental …

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Stress hyperglycaemia following trauma – a survival benefit or an outcome detriment?

Christopher Rugg, Stefan Schmid, Johannes Zipperle, Janett Kreutziger

PURPOSE OF REVIEW: Stress hyperglycaemia occur often in critically injured patients. To gain new consideration about it, this review compile current as well as known immunological and biochemical findings about causes and emergence. RECENT FINDINGS: Glucose is the preferred energy substrate for …

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Sex Differences in Mountain Bike Accidents in Austria from 2006 to 2018: A Retrospective Analysis

Simon Woyke, Anja Hütter, Christopher Rugg, Willi Tröger et autres

Woyke, Simon, Anja Hütter, Christopher Rugg, Willi Tröger, Bernd Wallner, Mathias Ströhle, and Peter Paal. Sex differences in mountain bike accidents in Austria from 2006 to 2018: a retrospective analysis. High Alt Med Biol. 25:89–93, 2024. Introduction:Mountain biking is becoming increasingly popular, …

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