Ingo Lorenz

Infection with SARS-CoV-2 Is Associated with Elevated Levels of IP-10, MCP-1, and IL-13 in Sepsis Patients

Tanja Eichhorn, Silke Huber, René Weiss, Marie Ebeyer-Masotta et autres

Immunothrombosis, an excessive inflammatory response with simultaneous overactivation of the coagulation system, is a central pathomechanism in sepsis and COVID-19. It is associated with cellular activation, vascular damage, and microvascular thrombosis, which can lead to multiple organ failure and death. Here, we …

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Radiographic and magnetic resonance imaging evaluation and characteristics of osseous cyst-like lesions in the equine hoof

N Sönnichsen, Ingo Lorenz, Kerstin Gerlach

Zusammenfassung: Zystoide Defekte gehören zu den immer wieder auftretenden Befunden im Bewegungsapparat des Pferdes mit nicht eindeutig geklärter Ursache.Auch ihre Bedeutung in der Lahmheitsdiagnostik ist schwer zu bestimmen.Die Ziele der vorliegenden Studie waren die Untersuchung der Häufigkeit des Auftretens von zystoiden Defekten …

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Pharmacokinetics and Antifungal Activity of Echinocandins in Ascites Fluid of Critically Ill Patients

René Welte, Herbert Oberacher, Tiziana Gasperetti, Hartwig Pfisterer et autres

The pharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG), and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during …

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Penetration of echinocandins into wound secretion of critically ill patients

Tiziana Gasperetti, René Welte, Herbert Oberacher, Jana Marx et autres

PURPOSE: Wound infections caused by Candida are life-threatening and difficult to treat. Echinocandins are highly effective against Candida species and recommended for treatment of invasive candidiasis. As penetration of echinocandins into wounds is largely unknown, we measured the concentrations of the echinocandins …

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A high leukocyte count and administration of hydrocortisone hamper PCR-based diagnostics for bloodstream infections

Silke Huber, Johannes Weinberger, Matthias Pilecky, Ingo Lorenz et autres

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A Prospective Pilot Trial to Assess the Efficacy of Argatroban (Argatra®) in Critically Ill Patients with Heparin Resistance †

Mirjam Bachler, Tobias Hell, Johannes Bösch, Benedikt Treml et autres

The current study aims to evaluate whether prophylactic anticoagulation using argatroban or an increased dose of unfractionated heparin (UFH) is effective in achieving the targeted activated partial thromboplastin time (aPTT) of more than 45 s in critically ill heparin-resistant (HR) patients. Patients …

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Pharmacokinetics of trimethoprim/sulfametrole in critically ill patients on continuous renal replacement therapy

René Welte, Rudolph Beyer, Johannes Hotter, Astrid Broeker et autres

OBJECTIVES: We investigated the effect of continuous renal replacement therapy (CRRT) on the pharmacokinetics of trimethoprim and sulfametrole. PATIENTS AND METHODS: We enrolled critically ill adults undergoing CRRT and critically ill adults with normal or slightly impaired renal function (plasma creatinine concentration …

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Successful Resuscitation Using Extracorporeal Membrane Oxygenation of 2 Patients With Severe Liver Rupture: A Case Report

Ingrid Haller, Wolfgang Lederer, Bernhard Glodny, Ingo Lorenz et autres

Extracorporeal membrane oxygenation is a rescue treatment for respiratory or cardiac failure. Its use is limited in patients predisposed to bleeding due to heparin administration. We present 2 patients with deranged coagulation after liver rupture successfully treated by extracorporeal membrane oxygenation. One …

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Intraventricular pressure in non-communicating hydrocephalus patients before endoscopic third ventriculostomy

Werner Tiefenthaler, Johannes Burtscher, Patrizia Moser, Ingo Lorenz et autres

BACKGROUND: In patients with non-communicating hydrocephalus impairment of cerebral compliance can occur pre- but also intraoperatively. METHODOLOGY: In such patients (n = 6) undergoing endoscopic third ventriculostomy (ETV), the present study aimed to investigate the effect of ETCO2 (e.g 40 mmHg and …

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Necrotizing fasciitis of the lower extremity caused by perforated sigmoid diverticulitis—a case report

Veronika Kröpfl, Benedikt Treml, Stefan Scheidl, Monika Lanthaler et autres

Diverticulosis of the sigmoid colon is a common condition and occurs more often in elderly patients. A well-known complication is infection or even perforation which often requires surgery. Necrotizing fasciitis as a complication of perforated diverticulitis is very rare. Here, we present …

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Acute coagulation disorder in a critically ill patient – A case report

Agnes Oberhuber, Benedikt Treml, D Friès, Ingo Lorenz et autres

A 79-year-old critically ill woman presented with remarkable prolongation of activated partial thromboplastin time and thrombin time combined with high levels of anti-factor IIa activity 26 days after coronary artery bypass grafting. Coagulation disorder was associated with severe bleeding. Cause of coagulopathy …

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Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients

René Welte, Philipp Eller, Ingo Lorenz, Michael Joannidis et autres

ABSTRACT Anidulafungin concentrations were quantified with high-pressure liquid chromatography (HPLC) and UV detection of the ascites fluid and pleural effusion of 10 adult critically ill patients. Samples were collected from ascites fluid and from pleural drains or during paracentesis and thoracentesis, respectively. …

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