Zihe Zhang

Postnatal gene restoration in succinic semialdehyde dehydrogenase deficiency (SSADHD) reveals phenotype reversibility

H. Lee, Gabrielle E. McGinty, Amanda Liebhardt, Zihe Zhang et autres

ABSTRACT Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare autosomal recessive metabolic disorder due to loss-of-function ALDH5A1 mutations impairing the catabolism of γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. In SSADHD, pathologic accumulation of GABA and its metabolic by-product …

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Machine Learning Approach to Predict Pain Outcomes Following Primary and Secondary Targeted Muscle Reinnervation in Amputees

Floris V. Raasveld, Zihe Zhang, Benjamin R. Johnston, Anna Luan et autres

INTRODUCTION: Targeted Muscle Reinnervation (TMR) can prevent and treat neuropathic pain in amputees, but the degree of success varies. This study developed a Machine Learning (ML) model to predict the likelihood of sustained pain mitigation following primary and secondary TMR based on …

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A machine learning tool with light-based image analysis for automatic classification of 3D pain behaviors

Omer Barkai, Bruna Lenfers Turnes, Maryam Arab, David A. Yarmolinsky et autres

Detailed assessment of pain-related behaviors in animals is essential for both exploring pain mechanisms and evaluating analgesic efficacy. While pose estimation tools have advanced automated behavior analysis, current existing algorithms often do not account for an animal's body-part contact intensity with-and distance …

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33. Machine Learning Approach to Predict Pain Outcomes Following Primary and Secondary Targeted Muscle Reinnervation in Amputees

Floris V. Raasveld, Zihe Zhang, Johnston Johnston, Anna Luan et autres

PURPOSE: Targeted Muscle Reinnervation (TMR) can effectively treat and prevent neuropathic pain (NP) in amputees, but its success varies among patients. This study developed a Machine Learning (ML) model to predict NP mitigation outcomes from Primary and Secondary TMR based on patient …

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ARBEL: A Machine Learning Tool with Light-Based Image Analysis for Automatic Classification of 3D Pain Behaviors

Omer Barkai, Biyao Zhang, Bruna Lenfers Turnes, Maryam Arab et autres

A detailed analysis of pain-related behaviors in rodents is essential for exploring both the mechanisms of pain and evaluating analgesic efficacy. With the advancement of pose-estimation tools, automatic single-camera video animal behavior pipelines are growing and integrating rapidly into quantitative behavioral research. …

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The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons

Lili Xie, Yuqin Yin, Selwyn S. Jayakar, Riki Kawaguchi et autres

Oncomodulin (Ocm) is a myeloid cell-derived growth factor that enables axon regeneration in mice and rats after optic nerve injury or peripheral nerve injury, yet the mechanisms underlying its activity are unknown. Using proximity biotinylation, coimmunoprecipitation, surface plasmon resonance, and ectopic expression, …

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Automated preclinical detection of mechanical pain hypersensitivity and analgesia

Zihe Zhang, David P. Roberson, Masakazu Kotoda, Bruno Boivin et autres

ABSTRACT: The lack of sensitive and robust behavioral assessments of pain in preclinical models has been a major limitation for both pain research and the development of novel analgesics. Here, we demonstrate a novel data acquisition and analysis platform that provides automated, …

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Dissecting the precise nature of itch-evoked scratching

Nivanthika K. Wimalasena, George Milner, Ricardo Silva, Cliff Vuong et autres

Itch is a discrete and irritating sensation tightly coupled to a drive to scratch. Acute scratching developed evolutionarily as an adaptive defense against skin irritants, pathogens, or parasites. In contrast, the itch-scratch cycle in chronic itch is harmful, inducing escalating itch and …

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Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

Frédéric Michoud, Corey R. Seehus, Philipp Schönle, Noé Brun et autres

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