Frédéric Michoud

Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants

Paul Chu Sin Chung, Valentina Paggi, Marie Pertin, Guylène Kirschmann et autres

Abstract Hyperexcitability of peripheral sensory neurons plays a critical role in the development and maintenance of chronic pain. Pharmacological analgesics used in clinics reduce neuronal activity. They often come with non‐negligible side effects. Optogenetic approaches can modulate neuronal activity and are attracting …

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Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Claudia Kathe, Frédéric Michoud, Philipp Schönle, Andreas Rowald et autres

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Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

Frédéric Michoud, Corey R. Seehus, Philipp Schönle, Noé Brun et autres

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Soft multimodal neural interfaces for unravelling sensory neurological circuits

Frédéric Michoud

Diseases or injuries affecting the nervous system can dramatically disrupt the quality of life. Despite extensive efforts towards treating dysfunctional nervous systems, the pharmacological and electrical approaches generally involved lack the temporal and spatial resolutions needed to selectively modulate neural activity. The …

Uniaxial strain of cultured mouse and rat cardiomyocyte strands slows conduction more when its axis is parallel to impulse propagation than when it is perpendicular

Andrea Buccarello, Michela Azzarito, Frédéric Michoud, Stéphanie Périchon Lacour et autres

AIM: Cardiac tissue deformation can modify tissue resistance, membrane capacitance and ion currents and hence cause arrhythmogenic slow conduction. Our aim was to investigate whether uniaxial strain causes different changes in conduction velocity (θ) when the principal strain axis is parallel vs …

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Optical cuff for optogenetic control of the peripheral nervous system

Frédéric Michoud, Loïc Sottas, Liam E. Browne, Léonie Asboth et autres

OBJECTIVE: Nerves in the peripheral nervous system (PNS) contain axons with specific motor, somatosensory and autonomic functions. Optogenetics offers an efficient approach to selectively activate axons within the nerve. However, the heterogeneous nature of nerves and their tortuous route through the body …

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Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses

Liam E. Browne, Alban Latrémolière, Brendan P. Lehnert, Alyssa Grantham et autres

Potentially harmful stimuli are detected at the skin by nociceptor sensory neurons that drive rapid protective withdrawal reflexes and pain. We set out to define, at a millisecond timescale, the relationship between the activity of these sensory neurons and the resultant behavioral …

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Uniaxial strain of cardiac tissue parallel to impulse propagation slows conduction more than in the perpendicular direction: untangling the effects of stretch on tissue resistance

Andrea Buccarello, Michela Azzarito, Frédéric Michoud, Stéphanie Périchon Lacour et autres

Reference EPFL-CONF-231603View record in Web of Science Record created on 2017-10-09, modified on 2017-10-09

MPS 11-08 Low power programmable pulse current source for wireless nerve stimulation and recording in small rodent

Qing Wang, Philipp Schoenle, Emmanuel Flück, Noé Brun et autres

Objective: To study neural reflex mechanisms in hypertension and neural disease in small rodent (rats and mice), implantable wireless nerve stimulation and recording system is required. We aim initially at establishing a low power programmable pulse current source for nerve wireless stimulation …

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A wireless system with stimulation and recording capabilities for interfacing peripheral nerves in rodents

Philipp Schönle, Frédéric Michoud, Noé Brun, Amélie Guex et autres

Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simultaneous peripheral nerve stimulation and neural …

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Correlation between muscular and nerve signals responsible for hand grasping in non-human primates

Swathi Sheshadri, Jukka Kortelainen, Sudip Nag, Kian Ann Ng et autres

Neuroprosthetic devices that interface with the nervous system to restore functional motor activity offer a viable alternative to nerve regeneration, especially in proximal nerve injuries like brachial plexus injuries where muscle atrophy may set in before nerve re-innervation occurs. Prior studies have …

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