Jonathan Hero Chung

Genetic liability to psoriasis predicts severe disease outcomes

Jake R. Saklatvala, Samuel Lessard, Maris Teder‐Laving, Laurent F. Thomas et autres

BACKGROUND: Psoriasis is a common inflammatory skin disease with heterogeneous presentation. Up to 30% of individuals have severe disease with a greater surface area of skin involvement, co-morbidity burden and impact on quality of life. Prognostic biomarkers of psoriasis severity could improve …

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Systemic Sclerosis-Associated Interstitial Lung Disease

Anthony Joseph Esposito, Kavitha C. Selvan, Carrie L. Richardson, Dinesh Khanna et autres

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Optimized 3D UTE and ZTE MRI for high‐resolution lung imaging: A comparative study

Michael Carl, Jiaji Wang, James Shui-ip Lo, Jonathan Hero Chung et autres

PURPOSE: To optimize and compare the performance of 3D UTE and zero echo time (ZTE) MRI sequences for high-resolution lung imaging at 3 T. METHODS: UTE and ZTE sequences were optimized for lung imaging through phantom studies, and in vivo experiments. Imaging …

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Clinical Implementation of Inspiratory-Expiratory Chest CT: Defining Quality Criteria for Diagnostic Quality and Detection of Concurrent FEV1 Decline following Lung Transplantation

Roshun R. Sankaran, Alexander Cypro, Kyle A. Hasenstab, Alta Steward et autres

Tracheal morphology and lung volume change between inspiratory and expiratory phases at chest CT can aid quality assurance and improve detection of chronic lung allograft dysfunction and decline in forced expiratory volume in 1 second in patients after lung transplantation.

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What role does artificial intelligence-driven quantitative analysis of chest computed tomography play in providing pulmonary function for idiopathic pulmonary fibrosis patients undergoing pirfenidone treatment?

Tongrui Zhang, Ju Hyung Lee, So Ri Kim, Jonathan Hero Chung et autres

Background: In patients with idiopathic pulmonary fibrosis (IPF), computed tomography (CT) quantification using artificial intelligence (AI) has been explored as a method to assess the therapeutic response to antifibrotic agents; however, studies evaluating long-term follow-up outcomes remain scarce. We investigated AI-driven quantitative …

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Misleading Model: Why the 5% Cancer Risk from Computed Tomography Scans Is Overstated

Jonathan Hero Chung, Christopher M. Walker, Lydia Chelala, Jeffrey P. Kanne

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A Quantitative Imaging Measure of Progressive Pulmonary Fibrosis

Jennifer M. Wang, Ayodeji Adegunsoye, Janelle Vu Pugashetti, Cathryn T. Lee et autres

Abstract Rationale Progressive pulmonary fibrosis (PPF) is common in patients with fibrotic interstitial lung disease (ILD) and leads to high mortality. Although PPF guideline criteria include computed tomography (CT)-based progression, these measures are qualitative and prone to interreader variability. Quantitative computed tomography …

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Current State of Fibrotic Interstitial Lung Disease Imaging

Lydia Chelala, Anupama Gupta Brixey, Stephen Hobbs, Jeffrey P. Kanne et autres

Interstitial lung disease (ILD) diagnosis is complex, continuously evolving, and increasingly reliant on thin-section chest CT. Multidisciplinary discussion aided by a thorough radiologic review can achieve a high-confidence diagnosis of ILD in the majority of patients and is currently the reference standard …

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Comprehensive Blood-based Transcriptomic Signature as a Biomarker for Honeycombing in Pulmonary Fibrosis

Katherine A Aracena, J. Oldham, C. Newton, Evans R. Fernández Pérez et autres

Abstract RATIONALE: Honeycombing (HC) fibrosis is an advanced sign of disease in pulmonary fibrosis (PF), portending poorer prognosis and significantly reduced survival across diverse subtypes of PF. While high-resolution chest CT scans are the gold standard for diagnosing HC, a blood-based transcriptomic …

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Histopathologic Honeycombing is Associated With Worse Mortality in Pulmonary Fibrosis

Barbara S. Aronson, Neha Kaushik, C.T. Lee, I. Udofia et autres

Abstract BACKGROUND: Pulmonary fibrosis (PF) within the spectrum of interstitial lung diseases (ILDs) is highly heterogeneous, with survival outcomes shaped by various radiographic, histopathologic, and clinical factors. Honeycombing, a hallmark of advanced fibrosis on imaging, is associated with poor prognosis. However, the …

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Pilot Multireader Study of Next Generation Chest X-ray Tomosynthesis for the Detection of Lung Cancer

Alexander Cypro, R. Sankaran, YoungRok Choi, Jihang Kim et autres

Abstract RATIONALE Lung cancer screening (LCS) with annual low-dose computed tomography (LDCT) decreases mortality by identifying early-stage cancer but uptake is limited, especially in medically under-resourced areas. Chest x-ray tomosynthesis (CXRT) is an alternative imaging approach that can be manufactured at one …

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ACR Appropriateness Criteria® Chronic Dyspnea-Noncardiovascular Origin: 2024 Update

Jared D. Christensen, Michael R. Harowicz, Christopher M. Walker, Brent P. Little et autres

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