A Quantitative Imaging Measure of Progressive Pulmonary Fibrosis
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Le résumé fourni par la source
Abstract Rationale Progressive pulmonary fibrosis (PPF) is common in patients with fibrotic interstitial lung disease (ILD) and leads to high mortality. Although PPF guideline criteria include computed tomography (CT)-based progression, these measures are qualitative and prone to interreader variability. Quantitative computed tomography (qCT) measurements have the potential to overcome this limitation. Objectives The objectives of this study were to determine whether changes in qCT measures of pulmonary fibrosis are associated with transplant-free survival (TFS) in a diverse ILD cohort and establish a quantitative computed tomography measure of progressive pulmonary fibrosis (qctPPF). Methods A retrospective cohort analysis was performed in individuals with fibrotic ILD, including idiopathic pulmonary fibrosis (n = 350), who underwent serial chest CT for clinical indications. Commercially available software was used to generate qCT measures of pulmonary fibrosis, which were tested for association with 2-year TFS using a multivariable Cox proportional hazards model. Iterative modeling was then performed to develop a composite qctPPF measure. Results were validated in an independent ILD cohort (n = 92). Measurements and Main Results Increasing ground-glass opacity and decreasing lung volume showed consistent association with decreased TFS across cohorts when modeled continuously and dichotomously. qctPPF classification was associated with a greater than threefold increased hazard of death or transplant in the test (hazard ratio, 4.41; 95% confidence interval, 2.77–7.03) and validation (hazard ratio, 3.54; 95% confidence interval, 1.62–7.71) cohorts. Agreement between qctPPF and radiologist-determined PPF was poor (κ = 0.20), with qctPPF classification maintaining prognostic significance when discordant with radiologist interpretation. Conclusions Changes in qCT measures are associated with clinically relevant outcomes and could improve PPF classification.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Quantitative Imaging Measure of Progressive Pulmonary Fibrosis
- Date Crossref
- 01/10/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Michigan Department of Microbiology and Immunology pays non établi dans la noticeUniversité ou école supérieure
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Michigan United pays non établi dans la noticeOrganisation à but non lucratif
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Michigan Medicine pays non établi dans la noticeÉtablissement de santé
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Pulmonary and Critical Care Associates pays non établi dans la noticeÉtablissement de santé
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University of Chicago Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Woodland Hills Medical Center pays non établi dans la noticeÉtablissement de santé
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Imbio (United States) pays non établi dans la noticeEntreprise
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University of California San Diego Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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University of California San Diego Medical Center pays non établi dans la noticeÉtablissement de santé
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Division of Pulmonary and Critical Care Medicine pays non établi dans la noticeInstitution
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Section of Pulmonary and Critical Care Medicine and pays non établi dans la noticeInstitution
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Department of Biostatistics pays non établi dans la noticeInstitution
Department of Microbiology and Immunology — University of Michigan, Michigan United et Michigan Medicine, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.