Karin Tran‐Lundmark

Risk factors for posttransplant lymphoproliferative disorder (PTLD) in pediatric heart recipients were associated with impairment of the immune system – a multicenter study from Sweden

Britt‐Marie Ekman‐Joelsson, Michal Odermarsky, Karin Tran‐Lundmark, Maria Sjöborg Alpman et autres

Background: Posttransplant lymphoproliferative disorder (PTLD) is a potentially lethal complication after pediatric heart transplantation (PHT). We have previously reported an association between PTLD and (1) sternotomy during infancy, (2) mismatch concerning Epstein-Barr virus infection, (3) hypoplastic left ventricle and (4) surgically palliated …

se (code pays fourni par la source)

Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning

Cristina Almagro-Pérez, Niccolò Peruzzi, Csaba Galambos, Andrew H. Song et autres

Histologically stained tissue sections are considered the gold standard for studying microscopic anatomy and diagnosing disease in clinical practice. However, the processes of sectioning and staining are laborious, and the overall method relies on two-dimensional analysis. In contrast, X-ray-based virtual histology offers …

ch, se, us (code pays fourni par la source)

Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension

M Moss, Timothy Klouda, Y Li, Ying Liu et autres

BACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by excessive remodeling of the distal arterioles and arteries, driven by endothelial cell (EC) apoptosis and uncontrolled mural cell proliferation. Increasing evidence suggests immune dysregulation in PAH, but one crucial part of the immune system, …

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Recent advances in the clinical management of end-stage pediatric pulmonary hypertension

Oscar van der Have, Rachel K. Hopper, Rebecca J. Kameny, Karin Tran‐Lundmark

PURPOSE OF REVIEW: This review aims to give an overview of recent advances in the clinical management of children <18 years of age with end-stage pulmonary hypertension refractory to conventional medical therapy. RECENT FINDINGS/SUMMARY: The increased awareness and characterization of pediatric pulmonary …

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The Nordic Experience of Pediatric Heart‐Lung Transplantation

Oscar van der Have, Michal Odermarsky, Thomas Möller, Klaus Juul et autres

BACKGROUND: Pediatric heart-lung transplantation (pHLTx) remains the only treatment option for children with significant and fixed elevation of pulmonary vascular resistance (PVR) in the setting of uncorrectable end-stage heart disease. We aimed to determine the characteristics, waiting list course and long-term outcomes …

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Supplementary Information from Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning

Cristina Almagro-Pérez, Niccolò Peruzzi, Csaba Galambos, Andrew Song et autres

SI_RoyalSociety_VISTACT_revised_12April2026.pdf

Supplementary Information from Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning

Cristina Almagro-Pérez, Niccolò Peruzzi, Csaba Galambos, Andrew Song et autres

SI_RoyalSociety_VISTACT_revised_12April2026.pdf

Efficient murine cardiac phenotyping by combining synchrotron-based phase-contrast micro-CT, histology, immunofluorescence and spatial transcriptomics

Niccolò Peruzzi, Ayse Ceren Mutgan, Kinga I. Gawlik, Timothy J. Mead et autres

1. Abstract Congenital heart disease is commonly studied using genetically modified mouse models, but characterization of complex three-dimensional (3D) cardiac anomalies remains technically challenging. Histology of fixed paraffin-embedded samples, typically used for structural and molecular analysis, is limited to two dimensions (2D). …

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Current availability and status of paediatric cardiac transplantation and mechanical circulatory support in twenty-eight European countries

Oscar van der Have, Esme Dunne, Karin Tran‐Lundmark, Julie Wacker et autres

We sought to investigate the inter- and intra-country variation in paediatric heart transplantation (HTx) and mechanical circulatory support (MCS) availability and practice in Europe. Data was obtained through a survey circulated to paediatric transplant cardiologists identified through the Association of European Paediatric …

se, ie, ch, us, at, cz, de, be, is, nl, hr, si, lv, tr, it, dk, ba, pt, pl, fi, hu, ro, sk, gb, no, fr (code pays fourni par la source)

Protein-losing enteropathy following Fontan completion: A 30-year national cohort study in Sweden

Mikaela Dolk, Indra Schütz, Erik Herou, Felicia Nordenstam et autres

OBJECTIVE: To characterize patients with protein-losing enteropathy (PLE) diagnosed before age 18 years within a nationwide Swedish Fontan cohort. METHODS: Surgical records and medical charts were reviewed for all patients born after January 1, 1993, who underwent Fontan completion before January 1, …

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Abstract 4363073: Somatic activating mutation in Phosphoinositide 3-kinase in a plexiform lesion of a patient with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension

Katharina Schimmel, Evon DeBose-Scarlett, Yue Qi, Serena Y. Tan et autres

Background: Hereditary hemorrhagic telangiectasia (HHT) and hereditary pulmonary arterial hypertension (HPAH) are genetic diseases that affect the pulmonary vasculature. HHT and HPAH are due to a haploinsufficiency in components of the bone morphogenetic protein receptor type 2 (BMPR2) pathway. Despite shared genetics, …

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Exploring the Impact of Platelet‐Derived Growth Factor D in Pulmonary Hypertension Development

Philip Tannenberg, Karin Tran‐Lundmark, Ya‐Ting Chang, Hanna Gladh et autres

ABSTRACT Pulmonary arterial hypertension (PAH) is a life‐threatening condition with no cure, making research into its underlying mechanisms critical. The platelet‐derived growth factor (PDGF) signaling pathway plays a crucial role in vascular remodeling, a key factor in PAH progression. Anti‐PDGF receptor therapies, …

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