Risk factors for posttransplant lymphoproliferative disorder (PTLD) in pediatric heart recipients were associated with impairment of the immune system – a multicenter study from Sweden
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Le résumé fourni par la source
Background: Posttransplant lymphoproliferative disorder (PTLD) is a potentially lethal complication after pediatric heart transplantation (PHT). We have previously reported an association between PTLD and (1) sternotomy during infancy, (2) mismatch concerning Epstein-Barr virus infection, (3) hypoplastic left ventricle and (4) surgically palliated congenital heart disease (CHD) as transplant indication versus cardiomyopathy (CMP). To explore whether there were significant differences in immunological profiles between the identified risk groups for PTLD and the rest of pediatric heart recipients. Methods: Data was partially collected as registry data from the previous study concerning PHT, PKT and HC 7. We then added clinical data and prospectively collected blood samples from additional PHT subjects from the 3 Swedish tertiary centers performing long-term follow-up after PHT. Blood samples were collected after transplantation (mean time 4.6 years, range 0.2-14.7 years) and were analyzed for immunophenotyping of T- and B-lymphocyte subpopulations and monocytes by flow cytometry, and T-cell receptor excision circles (TREC). Results: A total of 76 PHT subjects were included. Thirty-eight had undergone thymus excision during infancy and 22 had hypoplastic left ventricle. The transplant indication was CHD in 36 and CMP in 40 children. The immune profiles of the identified risk groups for PTLD were characterized by low numbers of TREC, naïve CD4+, naïve CD8+, naïve recent thymic emigrants (RTE) and among patients with CHD low numbers of T-helper cells (Th). In addition, the relative proportions of naïve cells were low. Conclusions: The identified PTLD risk groups demonstrated significant impairment in the immune system, a pattern consistent with immune dysfunction and features of immunological aging, both of which are conditions known to increase the risk of developing PTLD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Risk factors for posttransplant lymphoproliferative disorder (PTLD) in pediatric heart recipients were associated with impairment of the immune system – a multicenter study from Sweden
- Date Crossref
- 01/11/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sahlgrenska University Hospital Pediatric Heart Centre pays non établi dans la noticeÉtablissement de santé
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University of Gothenburg Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Lund University pays non établi dans la noticeUniversité ou école supérieure
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Skåne University Hospital Pediatric Heart Center pays non établi dans la noticeÉtablissement de santé
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Karolinska University Hospital Stockholm-Uppsala pays non établi dans la noticeÉtablissement de santé
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Karolinska Institutet pays non établi dans la noticeUniversité ou école supérieure
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Region Västra Götaland pays non établi dans la noticeOrganisme public
Pediatric Heart Centre — Sahlgrenska University Hospital, Department of Pediatrics — University of Gothenburg et Lund University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.