Accès ouvert
2026
preprint
OpenAlex
Frauke Senger, Susanne S. Hille, Anca Kliesow Remes, Tapan Kumar Baral et autres
Abstract Acute myocardial infarction (MI) is associated with severe metabolic and oxidative stress that triggers cardiomyocyte death, pro-inflammatory signaling and progressive structural remodeling frequently culminating in heart failure. Although significant advances in reperfusion therapy improved acute survival in patients, therapeutic strategies that …
de
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Accès ouvert
2026
preprint
OpenAlex
Abel Martín-Garrido, Nadine Weyrauch, Jorge Ruiz‐Orera, Jeanette Eresch et autres
Abstract Eukaryotic elongation factor 1A (eEF1A) delivers aminoacyl-tRNAs to ribosomes but also has additional, non-canonical functions. Mammals express two paralogs: eEF1A1 is ubiquitous, whereas eEF1A2 is confined to adult cardiomyocytes, skeletal myocytes, and neurons. Mutations in EEF1A2 cause cardiomyopathy, but underlying mechanisms …
de, us
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Accès ouvert
2025
erratum
OpenAlex
Feng Shao, Johanna Wieland, Yixin Wang, Merve Keleş et autres
In the original publication of this article [1], the author’s name “Felix A. Trogisch” was incorrectly written as “Trogisch Felix”. The original article has been corrected.
de
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2025
editorial
OpenAlex
Abel Martín-Garrido, Joerg Heineke
This editorial refers to ‘Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition’, by L.T. Timmer et al., https://doi.org/10.1093/cvr/cvaf021. Cardiac fibrosis describes pathological deposition of extracellular matrix (ECM), which can either be the consequence of cardiomyocyte …
de
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Accès ouvert
2025
article
OpenAlex
Feng Shao, Johanna Wieland, Yixin Wang, Merve Keleş et autres
Abstract Background Nucleoside diphosphate kinase B (NDPKB) deficiency in endothelial cells (ECs) promotes the activation of the hexosamine biosynthesis pathway (HBP), leading to vascular damage in the retina. The aim of this study was to investigate the consequences of NDPKB deficiency in …
de
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Accès ouvert
2024
article
OpenAlex
Merve Keleş, Steve Grein, Natali Froese, Dagmar Wirth et autres
lncRNAs to cardiomyocytes, where they bind and activate calmodulin-dependent kinase II, and impact pro-hypertrophic gene expression and calcium homeostasis. Therefore, we reveal a crucial lncRNA-based mechanism of EC-cardiomyocyte crosstalk during heart failure, which could be specifically modified in the future for therapeutic …
de
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Accès ouvert
2024
article
OpenAlex
Felix A. Trogisch, Aya Abouissa, Merve Keleş, Anne Birke et autres
Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to what extent endothelial cells also might contribute. We detected increased expression of the transcription factor Sox9 in endothelial cells in several different mouse fibrosis models. These models …
de, gb
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Accès ouvert
2023
article
OpenAlex
Vivien Kmietczyk, J. Oelschläger, Parul Gupta, Eshita Varma et autres
m 6 A mRNA methylation controls cardiomyocyte function and increased overall m 6 A levels are a stereotyping finding in heart failure independent of the underlying etiology. However, it is largely unknown how the information is read by m 6 A reader …
de, us
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Accès ouvert
2022
preprint
OpenAlex
Merve Keleş, Steve Grein, Natali Froese, Dagmar Wirth et autres
Abstract Background Pathological overload triggers maladaptive myocardial remodeling that leads to heart failure. Recent studies have shown that long non-coding RNAs (lncRNAs) regulate cardiac remodeling. This study investigates two recently discovered, secreted lncRNAs, Gadlor1 and Gadlor2 ( Gadlor 1/2 ). Methods We …
de
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Accès ouvert
2022
article
OpenAlex
Malgorzata Szaroszyk, Badder Kattih, Abel Martín-Garrido, Felix A. Trogisch et autres
Cachexia is associated with poor prognosis in chronic heart failure patients, but the underlying mechanisms of cachexia triggered disease progression remain poorly understood. Here, we investigate whether the dysregulation of myokine expression from wasting skeletal muscle exaggerates heart failure. RNA sequencing from …
de, gb
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Accès ouvert
2018
article
OpenAlex
Abel Martín-Garrido, Brandon J. Biesiadecki, Hussam E. Salhi, Yasin Shaifta et autres
The acceleration of myocardial relaxation produced by β-adrenoreceptor stimulation is mediated in part by protein kinase A (PKA)-mediated phosphorylation of cardiac troponin-I (cTnI), which decreases myofibrillar Ca 2+ sensitivity. Previous evidence suggests that phosphorylation of both Ser-23 and Ser-24 in cTnI is …
gb, us, au, in, mx
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Accès ouvert
2018
conference-abstract
OpenAlex
Jonathan C. Kentish, Abel Martín-Garrido, Brandon J. Biesiadecki, Hussam E. Salhi et autres
Funding Acknowledgements: Supported by grants from the British Heart Foundation (to JK and MA) and NIH (to BJB and YG) Introduction: The positive inotropic and lusitropic effects of β-adrenoceptor stimulation are mediated in part by protein kinase A (PKA)-mediated phosphorylation of cardiac …
gb, us, au
(code pays fourni par la source)