Christine Hacker

Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome

Ipek Akol, Annalisa Izzo, Fabian Gather, Stefanie Strack et autres

Forkhead box G1 (FOXG1) has important functions in neuronal differentiation and balances excitatory/inhibitory network activity. Thus far, molecular processes underlying FOXG1 function are largely unexplored. Here, we present a multiomics data set exploring how FOXG1 impacts neuronal maturation at the chromatin level …

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Integrative multi-omics analyses reveal multi-modal FOXG1 functions acting on epigenetic processes and in concert with NEUROD1 to regulate synaptogenesis in the mouse hippocampus

Ipek Akol, Stefanie Heidrich, Darren ÓhAilín, Christine Hacker et autres

Abstract Background FOXG1 has important functions for neuronal differentiation and balances excitatory/inhibitory network activity. Mutations in the human FOXG1 gene cause a rare neurodevelopmental disorder, FOXG1-syndrome, which manifests differing phenotypes, including severe cognitive dysfunction, microencephaly, social withdrawal, and communication and memory deficits. …

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Histone methylation during neural development

Deborah Roidl, Christine Hacker

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ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production

Christine Hacker, Ralitsa S. Valchanova, Stephanie Adams, Barbara Munz

Keratinocyte-derived growth factors and cytokines play an important role in epidermal homeostasis and particularly in cutaneous wound repair. Thus, we analyzed a potential role of the ZFP36/tristetraprolin family of zinc finger proteins, which are targets of these factors, but also regulate their …

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GAR22: A novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells

Ivonne Gamper, Ki‐Ryang Koh, David Ruau, Katrin Ullrich et autres

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Pluripotency Associated Genes Are Reactivated by Chromatin-Modifying Agents in Neurosphere Cells

David Ruau, Roberto Enseñat‐Waser, Timo C. Dinger, Duttu S. Vallabhapurapu et autres

Chromatin architecture in stem cells determines the pattern of gene expression and thereby cell identity and fate. The chromatin-modifying agents trichostatin A (TSA) and 5-Aza-2'-deoxycytidine (AzaC) affect histone acetylation and DNA methylation, respectively, and thereby influence chromatin structure and gene expression. In …

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Strong induction of the Tis11B gene in myogenic differentiation

Madleen Busse, Max Schwarzburger, Felicitas Berger, Christine Hacker et autres

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Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration

Alexander Prechtel, Nadine M. Turza, Dieter Kobelt, Jutta Eisemann et autres

Herpes simplex virus type 1 (HSV-1) is able to establish latency in infected individuals. In order to characterize potential new immune-escape mechanisms, mature dendritic cells (DCs) were infected with HSV-1 and total cellular RNA was isolated from infected and mock-infected populations at …

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Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation

Xinsheng Ju, Christine Hacker, Barbara Scherer, Vanessa Redecke et autres

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Transcriptional profiling identifies Id2 function in dendritic cell development

Christine Hacker, Ralf D. Kirsch, Xinsheng Ju, Thomas Hieronymus et autres

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Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling

Xinsheng Ju, Christine Hacker, Jaime Madruga, Steffen M. Kurz et autres

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Nuclear Factor κB–dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a Activity

M. Hinz, Petra Lemke, Ioannis Anagnostopoulos, Christine Hacker et autres

Constitutive nuclear nuclear factor (NF)-kappaB activity is observed in a variety of hematopoietic and solid tumors. Given the distinctive role of constitutive NF-kappaB for Hodgkin and Reed-Sternberg (HRS) cell viability, we performed molecular profiling in two Hodgkin's disease (HD) cell lines to …

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