Accès ouvert
2023
article
OpenAlex
Ahmed E.I. Hamouda, Carmen Schalla, Antonio S. Sechi, Martin Zenke et autres
Signaling through the HGF receptor/Met in skin-resident Langerhans cells (LCs) and dermal dendritic cells (DCs) is essential for their emigration toward draining lymph nodes upon inflammation-induced activation. In this study, we addressed the role of Met signaling in distinct steps of LC/dermal …
de
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Björn E. Clausen, Lukas Amon, Ronald A. Backer, Luciana Berod et autres
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization of mouse and human dendritic cells (DC) from lymphoid organs …
de, fr, sg, cn, at
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Nehar Celikkin, John Erik Wong, Martin Zenke, Thomas Hieronymus
Engineered magnetic nanoparticles (MNPs) are emerging as advanced tools for medical applications. The coating of MNPs using polyelectrolytes (PEs) is a versatile means to tailor MNP properties and is used to optimize MNP functionality. Dendritic cells (DCs) are critical regulators of adaptive …
de
(code pays fourni par la source)
2022
peer-review
OpenAlex
Björn E. Clausen, Lukas Amon, Ronald A. Backer, Luciana Berod et autres
2022
peer-review
OpenAlex
Björn E. Clausen, Lukas Amon, Ronald A. Backer, Luciana Berod et autres
Accès ouvert
2021
article
OpenAlex
Nathalie Diener, Jean−Fred Fontaine, Matthias Klein, Thomas Hieronymus et autres
Significance Conventional dendritic cells (cDC) and macrophages display a high phenotypic and functional heterogeneity. ADAM10 regulates diverse cellular activities via so-called ectodomain shedding of cell-surface proteins. Here, we report that mice with a CD11c-specific deletion of ADAM10 exhibit defective cDC subset homeostasis …
de, us
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Nehar Celikkin, John Erik Wong, Martin Zenke, Thomas Hieronymus
Abstract Engineered magnetic nanoparticles (MNPs) are emerging as advanced tools for medical applications. The coating of MNPs using polyelectrolytes (PEs) is a versatile means to tailor MNP properties and is used to optimize MNP functionality. Dendritic cells (DCs) are critical regulators of …
de
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Ahmed E.I. Hamouda, Carmen Schalla, Antonio S. Sechi, Martin Zenke et autres
Abstract Signaling by the HGF receptor/Met in skin-resident Langerhans cells (LC) and dermal dendritic cells (dDC) is essential for their emigration toward draining lymph nodes upon inflammation-induced activation. Here we addressed the role of Met-signaling in distinct steps of LC/dDC emigration from …
de
(code pays fourni par la source)
2019
conference-paper
OpenAlex
Ahmed Hamouda, C. Birchmeier, Martin Zenke, Thomas Hieronymus
Accès ouvert
2018
article
OpenAlex
Z. Sagi, Thomas Hieronymus
Langerhans cells (LCs), the epidermal dendritic cell (DC) subset, express the transmembrane tyrosine kinase receptor Met also known as hepatocyte growth factor (HGF) receptor. HGF is the exclusive ligand of Met and upon binding executes mitogenic, morphogenic, and motogenic activities to various …
de
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Tal Capucha, Noam Koren, Maria Nassar, Oded Heyman et autres
Mucosal Langerhans cells (LCs) originate from pre-dendritic cells and monocytes. However, the mechanisms involved in their in situ development remain unclear. Here, we demonstrate that the differentiation of murine mucosal LCs is a two-step process. In the lamina propria, signaling via BMP7-ALK3 …
il, de
(code pays fourni par la source)
2018
conference-paper
OpenAlex
Ahmed Hamouda, Z. Sagi, Jea-Hyun Baek, Martin Zenke et autres