Kai Funakawa

Early-onset Alzheimer’s disease with PSEN1 G206D mutation presenting with amnesia at an onset age of 29 years old

Kai Funakawa, Masanori Kurihara, Kensuke Takahashi, Ryoko Ihara et autres

The patient was a 36-year-old woman with normal birth and development. The patient experienced gradual memory loss from the age of 29 years old. The patient showed irritability at 35, convulsion at 36, and was diagnosed to have early-onset dementia. Family history …

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Proximal sensory neuropathy and cerebellar ataxia as presenting symptoms of NOTCH2NLC-related neuronal intranuclear inclusion disease

Kai Funakawa, Masanori Kurihara, Kensuke Takahashi, Mana Higashihara et autres

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Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation

Tomoki Kuwahara, Kai Funakawa, Tadayuki Komori, Maria Sakurai et autres

Leucine-rich repeat kinase 2 (LRRK2), the major causative gene product of autosomal-dominant Parkinson's disease, is a protein kinase that phosphorylates a subset of Rab GTPases. Since pathogenic LRRK2 mutations increase its ability to phosphorylate Rab GTPases, elucidating the mechanisms of how Rab …

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Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation

Tomoki Kuwahara, Kai Funakawa, Tadayuki Komori, Maria Sakurai et autres

Abstract Leucine-rich repeat kinase 2 (LRRK2), the major causative gene product of autosomal-dominant Parkinson’s disease, is a protein kinase that phosphorylates a subset of Rab GTPases. Since pathogenic LRRK2 mutations increase its ability to phosphorylate Rab GTPases, elucidating the mechanisms of how …

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GeoGebraの教育利用 : 面積測定と極限 (数式処理と教育)

Kai Funakawa

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Therapeutic strategies for intestinal Behçet's disease

Hiroshi Fujita, Fumisato Sasaki, Hitoshi Setoyama, Kai Funakawa et autres

Intestinal Behçet's disease (BD) is typically characterized by intestinal inflammation with discrete round or oval-shaped ulcers which are highly associated with gastrointestinal manifestations. Intestinal BD occasionally causes serious morbidity, such as gastrointestinal bleeding and perforation, and has a high postoperative recurrence rate. …

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P.3.a.004 Estimation of prevalence of major depression in patients with subacute myelo-optico- neuropathy

Takako Konishi, Manabu Hayashi, Souichi UENO, Souhei Yoshida et autres

[Survival in a case of pontine and extrapontine myelinolysis with marked parkinsonism].

K Mukai, Yoji Yasuda, Haruhisa Kato, Kai Funakawa et autres