Ido P. Kema

Human platelet 5-hydroxyindoleacetic acid concentrations are meager and unlikely to be physiologically active or play a role in inflammation

George M. Anderson, Martijn van Faassen, Ido P. Kema

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Development and validation of an LC-MS/MS method for the analysis of total ascorbic acid capacity in plasma

Dylan S. Kelly, Claude P. van der Ley, Ron Booij, Ido P. Kema et autres

A robust and fast LC-MS/MS method for quantifying total ascorbic acid (vitamin C) in plasma was developed and validated. Ascorbic acid is vital for antioxidant defense and enzymatic processes. Deficiency and hypovitaminosis remain prevalent in specific patient groups and can result in …

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The kynurenine pathway in pediatric “mild-to-moderate” traumatic brain injury: translational insights from a prospective human study and a large-animal model

Harm J. van der Horn, Koen Visser, Tracey V. Wick, Samuel D. Miller et autres

Elucidating the biochemical pathways affected by pediatric traumatic brain injury (TBI) is essential for identifying informative blood-based biomarkers that may support future precision medicine and clinical trials. The kynurenine pathway (KP)-the primary route for tryptophan (Trp) degradation-represents a promising candidate due to …

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Association of Catecholamines with Blood Glucose and Severity of Illness in Infants Born Preterm

Henrike Hoermann, Marcia Roeper, Martijn van Faassen, Carsten Hagenbeck et autres

OBJECTIVE: To assess whether urinary catecholamine/metanephrine concentrations correlate with illness severity and blood glucose (BG) levels during the first weeks of life among infants born preterm. STUDY DESIGN: This was a prospective cohort study of 33 neonates born at <32 + 0 …

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Reply to Letter to the Editor: Beyond the gut: Systemic levels of short-chain fatty acids are altered in patients with heart failure

Constantin L. Palm, Stéphane De Wit, Thomas M. Gorter, Michiel Rienstra et autres

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Critical Pitfalls in the Flow Cytometric Analysis of Mast Cells in Patients With Systemic Mastocytosis

Abdulrazzaq Alheraky, Kees Meijer, Marije T. Nijk, Saskia K. Klein et autres

Systemic mastocytosis (SM) is a neoplastic disease characterized by abnormal mast cell (MC) activation and proliferation. Accurate diagnosis often relies on flow cytometry to detect aberrant CD25, CD2, and CD30 expression on MCs in bone marrow (BM). However, the frequently low abundance …

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Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approach

Abdulrazzaq Alheraky, Claude P. van der Ley, Martijn van Faassen, Saskia K. Klein et autres

OBJECTIVES: Histamine, mainly produced in mast cells (MC), plays a key role in allergy and inflammation. Measuring its urinary metabolites, N-methylhistamine (NMH) and 1-methyl-4-imidazoleacetic acid (MIMA), is essential in assessing histamine-related pathologies. Patients with concurrent systemic mastocytosis (SM) and hereditary alpha tryptasemia …

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Psychiatric and cognitive function in patients with serotonin producing neuroendocrine tumors

Maryse J. Luijendijk, Margot Tesselaar, Huub H. van Rossum, Martijn van Faassen et autres

Cognitive and psychiatric problems are common in cancer patients, but literature on patients with neuroendocrine tumors (NET) is scarce. In a subset of these patients, the tumor produces serotonin, causing physical symptoms known as carcinoid syndrome. This peripheral overproduction of serotonin may …

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Pre-transplant residual diuresis and oxalic acid concentration influence kidney graft survival

Gideon Post Hospers, Mirjam Laging, Wesley J. Visser, Pedro Miranda Afonso et autres

BACKGROUND AND HYPOTHESIS: Oxalic acid, a toxic metabolic end product, accumulates when kidney function deteriorates. Apart from its direct tubulotoxicity, it crystallizes at concentrations above 30-40 µmol/L. High oxalic acid concentrations at transplantation might negatively influence kidney transplant function. The influence of …

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Dietary intake of oxalic acid affects plasma oxalic acid concentration in patients with kidney failure

Wesley J. Visser, Gideon Post Hospers, Anneke M E van Egmond, Mirjam Laging et autres

BACKGROUND & AIMS: Hyperoxaluria may cause kidney stones, kidney function decline and eventually kidney (transplant) failure. High plasma concentrations may lead to systemic oxalosis. Plasma oxalic acid concentrations increase when kidney function deteriorates. Apart from kidney function, the contribution of dietary intake …

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Hair cortisol as a marker of stress in mild traumatic brain injury: a challenging measure

Diana Ciubotariu, Koen Visser, Myrthe E. de Koning, Jacoba M. Spikman et autres

Cortisol is released through activation of the hypothalamic-pituitary-adrenal axis by physiological and psychological stressors, such as mild traumatic brain injury (mTBI). This hormone is accumulated in hair over longer periods of time, reflecting both acute and chronic forms of stress, allowing for …

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Beyond the gut: Systemic levels of short-chain fatty acids are altered in patients with heart failure

Constantin L. Palm, Stéphane De Wit, Thomas M. Gorter, Michiel Rienstra et autres

BACKGROUND & AIM: The gut microbiome produces short-chain fatty acids (SCFAs), which serve as a substantial energy source and provide a link between the microbiome and (cardiac) metabolism. It has been demonstrated that the composition of the microbiome is altered in patients …

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