Marije T. Nijk

Transformed FL shows improved survival after CAR T-cell therapy compared to de novo LBCL, but early transformation (<12 months) defines a poor-risk subgroup: Results from a nationwide cohort

Hilde Van Der Galien, Pim Mutsaers, Margot Jak, Marjolein van der Poel et autres

Abstract Background Large B-cell lymphoma (LBCL) can arise from transformation of indolent lymphomas, most commonly follicular lymphoma (FL). While only 5-10% of 1st line LBCL cases are transformed FL (tFL), this increases to ~30% in the ≥3rd line CAR T-cell therapy (CART) …

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Critical Pitfalls in the Flow Cytometric Analysis of Mast Cells in Patients With Systemic Mastocytosis

Abdulrazzaq Alheraky, Kees Meijer, Marije T. Nijk, Saskia K. Klein et autres

Systemic mastocytosis (SM) is a neoplastic disease characterized by abnormal mast cell (MC) activation and proliferation. Accurate diagnosis often relies on flow cytometry to detect aberrant CD25, CD2, and CD30 expression on MCs in bone marrow (BM). However, the frequently low abundance …

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Early ICANS recognition with a novel electroencephalogram-based deltawave detection system in patients receiving CAR T-cell therapy

Marieke Tienstra, Tatum N. Storck, Hilde T. van der Galiën, Janneke de Boer et autres

Immune effector cell-associated neurotoxicity syndrome (ICANS) is a potential life-threatening treatment-related adverse event of chimeric antigen receptor (CAR) T-cell therapy. Early recognition of patients at risk of ICANS is crucial and may guide use of steroids in these patients. Measuring polymorphic delta …

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CombiFlow: combinatorial AML-specific plasma membrane expression profiles allow longitudinal tracking of clones

Roos Houtsma, Nisha K van der Meer, Kees Meijer, Linde M. Morsink et autres

Acute myeloid leukemia (AML) often presents as an oligoclonal disease whereby multiple genetically distinct subclones can coexist within patients. Differences in signaling and drug sensitivity of such subclones complicate treatment and warrant tools to identify them and track disease progression. We previously …

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Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones

Bauke de Boer, Janine Prick, Maurien Pruis, Peter Keane et autres

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Opsonization of late apoptotic cells by systemic lupus erythematosus autoantibodies inhibits their uptake via an Fcγ receptor–dependent mechanism

Esther Reefman, Gerda Horst, Marije T. Nijk, Pieter C. Limburg et autres

OBJECTIVE: Decreased clearance of apoptotic cells is suggested to be a major pathogenic factor in systemic lupus erythematosus (SLE). The aim of this study was to investigate whether the binding of SLE autoantibodies to apoptotic cells influences the phagocytosis of these cells …

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Opsonization of late apoptotic cells by systemic lupus erythematosus (SLE) autoantibodies inhibits their uptake via an Fc gamma R-dependent mechanism

Esther Reefman, Gerda Horst, Marije T. Nijk, P. C. Limburg et autres

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Opsonization of apoptotic cells by systemic lupus erythematosus (SLE) autoantibodies inhibits their uptake by macrophages via a Fc gamma R-dependent mechanism.

Esther Reefman, Gerda Horst, Marije T. Nijk, Pieter Limburg et autres

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