Tracey V. Wick

Injury Severity Influences Long‐Term Cognitive Control in Pediatric “Mild” Traumatic Brain Injury

Upasana Nathaniel, Tracey V. Wick, Josef M. Ling, Vadim Zotev et autres

Pediatric "mild" traumatic brain injury (pmTBI), or concussion, is increasingly associated with persisting and often undiagnosed cognitive difficulties, particularly, in adolescents. Emerging evidence suggests that these deficits are most pronounced during tasks requiring competing attentional demands (i.e., reactive control). However, it remains …

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Oscillating hypercapnia induces neural abundant protein efflux and potential depletion in health and chronic traumatic brain injury

Andrew Mayer, Tracey V. Wick, Upasana Nathaniel, Sephira G. Ryman et autres

-induced low frequency hemodynamic oscillations during magnetic resonance imaging would increase clearance of proteins (glial fibrillary acidic protein, neurofilament light chain, ptau217, and brain-derived tau) from brain to blood, and temporarily improve cognitive performance in individuals with chronic traumatic brain injury (TBI) …

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Early Predictors of Long-Term Outcomes in Pediatric “Mild” Traumatic Brain Injury: A Machine Learning Approach

Upasana Nathaniel, Erik B. Erhardt, Divyasree Sasi Kumar, Jingshu Wu et autres

While most children recover from pediatric “mild” traumatic brain injury (pmTBI), up to one-third experience persisting symptoms after concussion (PSaC) that interfere with school, social, and emotional functioning. Clinicians face the dual challenge of low PSaC rates and nonspecific symptom rating even …

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Oscillating Hypercapnia Induces Neural Abundant Protein Efflux and Potential Depletion in Health and Chronic Traumatic Brain Injury

Andrew R. Mayer, Tracey V. Wick, Upasana Nathaniel, Sephira G. Ryman et autres

Abstract Emerging preclinical and clinical evidence suggests that low frequency hemodynamic oscillations drive CSF flow, which in turn mediates glymphatic clearance. The current study investigated whether CO 2 -induced low frequency hemodynamic oscillations during magnetic resonance imaging would increase clearance of proteins …

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Mechanisms and barriers for understanding neural abundant protein efflux following traumatic brain injury

Andrew R. Mayer, Tracey V. Wick, Samuel Miller, Kristin E. Connors et autres

Quantifying traumatic brain injury (TBI) based on peripheral fluid protein concentrations is increasingly recommended by expert consensus panels. However, critical knowledge gaps remain regarding underlying mechanisms (e.g. de novo protein synthesis, changes in barrier permeabilities and/or glymphatic clearance), especially for “milder” injuries. …

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An Evaluation of Aeromedical Evacuation Strategies Following Traumatic Brain Injury and Severe Blood Loss

Andrew R. Mayer, Amy L Lloyd, Harm J. van der Horn, Ciara S Grunig et autres

Individuals experiencing severe polytrauma are typically transported to the highest level of care as soon as possible, including helicopter evacuation from remote and/or rural environments. However, several recent preclinical and clinical studies have suggested that aeromedical evacuation exacerbates central nervous system injury …

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The kynurenine pathway in pediatric “mild-to-moderate” traumatic brain injury: translational insights from a prospective human study and a large-animal model

Harm J. van der Horn, Koen Visser, Tracey V. Wick, Samuel D. Miller et autres

Elucidating the biochemical pathways affected by pediatric traumatic brain injury (TBI) is essential for identifying informative blood-based biomarkers that may support future precision medicine and clinical trials. The kynurenine pathway (KP)-the primary route for tryptophan (Trp) degradation-represents a promising candidate due to …

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Optimizing pediatric “Mild” traumatic brain injury assessments: A multi-domain random forest analysis of diagnosis and outcomes

Upasana Nathaniel, Erik B. Erhardt, Divyasree Sasi Kumar, Jingshu Wu et autres

Objective: Despite advances in imaging and fluid-based biomarkers, the care for pediatric "mild" traumatic brain injury (pmTBI) remains primarily dependent on clinical evaluation. However, the optimal clinical assessments for diagnosing pmTBI and predicting outcomes remain debated, including which individual test or combinations …

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Anticoagulate the Circuit, Not the Patient: Nitric Oxide Reduces Thrombus Formation During Extracorporeal Carbon Dioxide Removal

Teryn R. Roberts, Yanyi Zang, George T. Harea, Daniel Wendorff et autres

Solutions to reduce the need for systemic anticoagulation during extracorporeal life support would improve safety and utility. The study objective was to evaluate the safety and efficacy of a nitric oxide-generating extracorporeal carbon dioxide removal (ECCO 2 R) system without systemic anticoagulation …

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Regional and Global Changes in Brain Structure 1‐Year Post Pediatric “Mild” Traumatic Brain Injury

Upasana Nathaniel, Tracey V. Wick, Josef M. Ling, Jessica R. McQuaid et autres

OBJECTIVE: Despite the high prevalence of pediatric "mild" traumatic brain injury (pmTBI), very little is known about the long-term effects of injury on brain structure and how injuries manifest in the context of dynamic and regionally specific neurodevelopmental changes. METHODS: Prospective study …

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Relationship Between Rotational Device Kinematics and Head Kinematics in a Large Animal Model of Traumatic Brain Injury

Declan A. Patton, Ciara S Grunig, Jessica R. McQuaid, Josef M. Ling et autres

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Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury

Andrew R. Mayer, Tracey V. Wick, Jessica R. McQuaid, Masen L. Boucher et autres

Pediatric mild traumatic brain injury (pmTBI) affects millions of youth annually but underlying pathophysiology and time for physiological recovery remains unknown. Non-fasting plasma samples were obtained in 59 pmTBI (28 females; age 14.9 ± 2.7) at approximately 7 days and 4 months …

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