Michele Pellegrino

Small Epidemic Outbreak of Norovirus in the Pediatric Department of Brescia Civic Hospital (Northern Italy): Genomic Characterization and Phylogenetic Analysis

Michele Pellegrino, Anna Bertelli, Laura Dotta, Sara Roversi et autres

BACKGROUND: Human noroviruses are a leading cause of acute gastroenteritis worldwide, with GII.4 Sydney 2012 [P16], being the predominant circulating genotype in Italy in recent years. Outbreaks in pediatric hospital wards represent a major public health concern. METHODS: Eight stool samples collected …

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Molecular insights into Silodosin’s anti-cancer effects: a promising repurposing strategy for breast cancer

Michele Pellegrino, Maria Antonietta Occhiuzzi, Maria Marra, F. Giordano et autres

Breast cancer, the most common cancer diagnosed among women worldwide, remains a significant clinical challenge due to its molecular heterogeneity and the development of resistance to conventional therapies. This study investigates the potential of silodosin, an α1A-adrenergic receptor (AR) antagonist, as a …

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Metformin Suppresses Glioblastoma Tumor Growth and Progression Through the AMPK/FoxO3a/Survivin Axis

Fabiola Cavaliere, Michele Pellegrino, Alessandro Cormace, Sofia Spadafora et autres

Glioblastoma (GB) is one of the most aggressive malignant brain tumors. Due to the high invasiveness of this cancer, surgical removal is often not possible, and relapses after surgery are very common, making current treatments ineffective. Developing new therapies or treatment combinations …

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Lactic Acid Bacteria for Fungal Control and Shelf-Life Extension in Fresh Pasta: Mechanistic Insights and Clean-Label Strategies

Noor Sehar, Roberta Pino, Michele Pellegrino, Monica Rosa Loizzo

The global food industry is undergoing a major shift driven by increasing consumer demand for clean-label and naturally preserved foods. Fresh pasta is highly vulnerable to fungal damage because of its high water activity (aw > 0.85), typically ranging between 0.92 and …

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Glycyrrhiza glabra L. Extracts Prevent LPS-Induced Inflammation in RAW264.7 Cells by Targeting Pro-Inflammatory Cytokines, Mediators and the JAK/STAT Signaling Pathway

Maria Rosaria Perri, Michele Pellegrino, Claudia-Crina Toma, Pierfrancesco Prezioso et autres

Glycyrrhiza glabra L. is a species widely spread all over the world, with a long tradition of use in folk medicine. Here, raw and hydrolyzed extracts obtained from roots collected in different geographical areas belonging to the Mediterranean basin were standardized as …

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Top-down determinants of the numerosity-time interaction

Irene Petrizzo, Michele Pellegrino, Giovanni Anobile, Fabrizio Doricchi et autres

This is the dataset related to the article:"Top-down determinants of the numerosity-time interaction" The file contains subjects data for the four experimentsFor the .csv file: sub_ID is the participant's identification number PSE indicates the Point of Subjective Equality for the Specified Condition …

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Recent advances in innovative strategies for controlling microbial growth in food system: a concise review

Michele Pellegrino, Jasper Okoro Godwin Elechi, Rosa Tundis, Roberta Pino et autres

Food preservation is a longstanding discipline encompassing traditional techniques such as sun drying, roasting, smoking, fermenting, and salting to maintain agricultural products. Current estimates indicate that one-third of agricultural product is lost to food deterioration, with 25% of the overall food loss …

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Determinants of speech intelligibility in laryngectomized patients with voice prostheses

Francesco Mattioli, Sara Donvito, Michele Pellegrino

Searching for New Gold(I)-Based Complexes as Anticancer and/or Antiviral Agents

Paola Checconi, Annaluisa Mariconda, Alessia Catalano, Jessica Ceramella et autres

Approaches capable of simultaneously treating cancer and protecting susceptible patients from lethal infections are highly desirable, although they prove challenging. Taking inspiration from the well-known anticancer platinum complexes, successive studies about the complexation of organic compounds with other late transition metals, such …

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Antibacterial and Anti-Influenza Activities of N-Heterocyclic Carbene–Gold Complexes

Michele Pellegrino, Paola Checconi, Jessica Ceramella, Carla Prezioso et autres

Background/Objectives: Infectious diseases represent a serious threat due to rising antimicrobial resistance, particularly among multidrug-resistant bacteria and influenza viruses. Metal-based complexes, such as N-heterocyclic carbene–gold (NHC–gold) complexes, show promising therapeutic potential due to their ability to inhibit various pathogens. Methods: Eight NHC–gold …

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When Chirality Makes the Difference: The Case of Novel Enantiopure N-Heterocyclic Carbene–Gold and –Silver Complexes

Maria Marra, Annaluisa Mariconda, Domenico Iacopetta, Jessica Ceramella et autres

N-heterocyclic carbene (NHC)–gold and –silver complexes have attracted the interest of the scientific community because of their multiple applications and their versatility in being chemically modified in order to improve their biological properties. However, most of these complexes contain one or more …

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New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs

Maria Marra, Alessia Catalano, Maria Stefania Sinicropi, Jessica Ceramella et autres

More than 80 million people worldwide have been infected with the human immunodeficiency virus (HIV). There are now approximately 39 million individuals living with HIV/acquired immunodeficiency syndrome (AIDS). Although treatments against HIV infection are available, AIDS remains a serious disease. Combination antiretroviral …

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