Ruixing Chen

Design of functional hydrogel beads based on polysaccharide-encapsulated Ganoderma lucidum spores for stability and targeted gastrointestinal delivery of protein–spore complex

Longqin Li, Ang Ma, Ni Jiang, Ruixing Chen et autres

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Enhancing the anti-inflammatory efficacy of polysaccharides through processing techniques: a case study on Atractylodes macrocephala

Hong-Da Xuan, Sheng-Nan Shen, Chunjin Fu, Jie Zhou et autres

Koidz., or Bai-Zhu, is commonly used in Traditional Chinese Medicine (TCM) for its gastrointestinal and metabolic benefits. The processing of Bai-Zhu with Aurantii Fructus Immaturus (AFI) enhances its therapeutic effects, though the underlying molecular mechanisms remain unclear. This study compared the chemical …

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Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer

Qixiang Shi, Huiying Li, Peili Wang, Fuchao Chen et autres

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Surface-modifying Ganoderma lucidum spores as improved microcarriers in protein delivery

Ruixing Chen, Ang Ma, Jingjing Liao, Yuqing Meng et autres

Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3

Wenhua Kuang, Ping Song, Letai Yi, Shujie Zhang et autres

Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug for cancers and immune disorders. Here, we …

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Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells

Ling Huang, Guanjun Li, Ying Zhang, Shijie Qin et autres

INTRODUCTION: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with the worst prognosis. Exploring novel carcinogenic factors and therapeutic drugs for TNBC remains a focus to improve prognosis. Branched-chain amino acid transaminase 1 (BCAT1), a crucial enzyme in …

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Deciphering single-cell transcriptomic landscape of tumors in colorectal cancer treated with photothermal semiconducting polymers to design the combination therapy with checkpoint blockades for inhibition of tumor progression and metastasis

Haitao Yuan, Yunmeng Bai, Di Gu, Peili Wang et autres

Immunotherapy is often less effective for tumors with “immune-excluded,” or “immune-desert” microenvironment. To circumvent this hurdle, new therapeutic strategies need to be designed to reprogram the tumor microenvironment (TME). It is well known that photothermal therapy (PTT) can prime the TME and …

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IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways

Z Zhang, Mingzhen Yang, Ruixing Chen, Wen‐Pin Su et autres

Epithelial-to-mesenchymal transition (EMT) is a crucial process for the invasion and metastasis of epithelial tumors. However, the molecular mechanisms underlying this transition are poorly understood. In this study, we demonstrate that interferon regulatory factor 4 binding protein (IBP) regulates EMT and the …

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