Yunmeng Bai

Engineered bacterial outer membrane vesicles integrated with photothermal therapy: disrupting the CD47-SIRPα axis to enhance pyroptosis and antitumor immunity

Haitao Yuan, Yanting Liang, Yunmeng Bai, Junhui Chen et autres

Bacterial outer membrane vesicles (OMVs) garner significant attention in tumor therapy due to their unique ability to selectively target and eliminate tumor cells. However, tumor cells commonly overexpress CD47, a “don’t eat me” signal that interacts with signal regulatory protein alpha (SIRPα) …

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Systemic mapping of senescence characteristics across septic tissues

Chen Zhou, Yunmeng Bai

Sepsis triggers profound organism-wide disturbances, yet the cellular logic underlying its systemic impact remains poorly defined. By integrating single-cell transcriptomes from six septic tissues, we uncovered a conserved cross-tissue program characterized by inflammation-driven senescence, disrupted intercellular communication, and coordinated transcriptional reprogramming. Senescence …

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Carrier-Free Ce6&SR717 Nanomedicine Enables Abscopal Photoimmunotherapy via cGAS-STING Activation in Breast Cancer

Xin Peng, Yi Sun, Yudong Guan, Tong Su et autres

Potent STING agonists are among the most promising strategies for reversing immunosuppression in “cold” tumors, but in vivo antitumor efficacy is frequently limited by dose-limiting systemic toxicity and inadequate tumor selectivity. To achieve localized STING activation and robust systemic immunity, we combined …

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Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging

J Huang, Xin Sun, Huadong Liu, K E X I N Li et autres

Aging is a well-recognized risk factor in cardiovascular diseases (CVDs), primarily due to its association with the gradual decline in cardiac function. This decline significantly influences the pathogenesis of common CVDs such as myocardial infarction and heart failure. Despite the existence of …

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Abnormal Temporal Variability Organization Associated with Compromised Verbal Memory and Psychotic Symptoms in Schizophrenia Patients and Their First-Degree Relatives

Yajing Si, Jiayu Ye, Yan Zhu, Hongxing Zhang et autres

Schizophrenia (SCZ) is a highly disabling psychiatric disorder marked by compromised brain dynamic interactions. However, the underlying neuropathology of SCZ remains poorly elucidated in terms of its associated disruption of network-level and rhythm-specific dynamic fluctuations during the resting state. Herein, using a …

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ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates NMOSD pathology

Haixia Wen, Yinyu Zi, Zhuhe Liu, Yunmeng Bai et autres

Neuromyelitis optica spectrum disorder (NMOSD) is recognized as a form of astrocytopathy; however, the mechanisms underlying aquaporin (AQP)4-IgG-induced astrocytic dysfunction remain to be fully elucidated. Here, single-nucleus RNA sequencing revealed that astrocytic ferroptosis is observed in mouse models of NMOSD, accompanied by …

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Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma

Jiayun Chen, Wenmin Lu, Yanni Lou, Jing Liu et autres

Hepatocellular carcinoma (HCC) is the most common primary liver carcinoma with high lethality. Both of hepatitis B virus (HBV) and Clonorchis sinensis ( C. sinensis ) are critical infectious contributors to HCC development. However, the inter-tumor heterogeneity and tumor microenvironment (TME) of …

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Multifunctional Metal Polyphenol Nanoparticles Based on Photothermal Therapy for Bacterial Eradication and Wound Healing

Haitao Yuan, Mengyun Hou, Min Zou, ShiYan He et autres

Balancing short-term antibacterial needs with long-term anti-inflammatory effects remains a major challenge in wound healing. Multifunctional bioactive materials capable of both efficient antibacterial action and inflammation modulation represent a promising solution. However, the majority of traditional antibacterial biomaterials possess only a single …

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Examining clinical symptoms in schizophrenia based on visual-spatial working memory and resting-state EEG

Yajing Si, Yunmeng Bai, Jiaxin Wang, Wenjing Zhong et autres

Schizophrenia (SZ) is a serious and disabling mental illness characterized by compromised brain network interactions. The current study investigated the potential associations between the resting-state electroencephalogram (EEG) and individual cognitive traits/clinical recordings in SZ patients. Furthermore, the positive and negative syndrome scale …

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Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity

Junhui Chen, Qian Zhang, Jingnan Huang, Hengkai He et autres

Rifampicin (RIF), a cornerstone drug in tuberculosis treatment, is associated with hepatotoxicity, which represents a significant adverse effect that frequently causes discontinuation of therapy.However, a comprehensive evaluation of the mechanisms underlying RIF-induced hepatotoxicity remains limited, and the identification of highly effective, low-toxicity …

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In Situ Self-Assembled Phytopolyphenol-Coordinated Nanoagents for Healing Bacterial Infections and Inhibiting Inflammation via Photothermal Therapy

Haitao Yuan, Wenzhe Chen, Jingxu Wang, Yuanyuan Wang et autres

Pathogenic bacterial infections, which can perpetuate a harmful cycle of inflammation and hinder wound healing. Consequently, constructing a multifunctional strategy that can both eradicate bacteria and alleviate excessive inflammation holds great significance for wound healing. Herein, this study developed multifunctional metal-phenolic nanopreparations …

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Size dependent nephrotoxicity of polystyrene microplastics revealed by single-cell transcriptomics profiling

Chen Wang, Tong Yang, Ang Ma, Yunmeng Bai et autres

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