Amy M. Taylor

Preoperative Weight Loss in Patients With Excess Weight and Colorectal Cancer

Dimitrios A. Koutoukidis, Susan Ann Jebb, Sophie Reynolds, T. Martyn Hill et autres

Importance: Excess weight increases morbidity risk after colorectal cancer surgery. Objective: To assess the feasibility of a preoperative weight loss intervention. Design, Setting, and Participants: CARE was an assessor-blinded randomized clinical trial performed between March 27, 2023, to August 13, 2024, with …

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Prepectoral no mesh versus mesh immediate implant-based reconstruction after mastectomy (Restore-B): a multicentre single-blinded randomised controlled feasibility study protocol

Rachel Rolph, Sue Ziébland, Jonathan Alistair Cook, Cynthia P Iglesias-Urrutia et autres

INTRODUCTION: Breast cancer is common and women requiring mastectomy will be offered a breast reconstruction if they are surgically suitable candidate. Breast reconstruction can be performed at the same time as the mastectomy (immediate) or delayed to a second operation after cancer …

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Protocol for the GOLF trial: randomized clinical trial on the LINX management system versus fundoplication for the surgical treatment of gastro-oesophageal reflux disease

Sheraz Rehan Markar, Begüm Zeybek, Nainika Suresh Menon, Ahmed Ahmed et autres

Gastro-oesophageal reflux disease (GORD) represents a significant burden on the Western healthcare system, affecting up to 20% of adults, with a rising prevalence1,2. GORD negatively impacts a patient’s health-related quality of life (HRQoL) and is associated with an increased risk of complications, …

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Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial

Richard J. Bryant, Ioana R. Marian, R. Williams, José Francisco Juárez López et autres

BACKGROUND: Prostate cancer diagnosis requires biopsy, traditionally performed under local anaesthetic with ultrasound guidance via a transrectal approach (TRUS). Local anaesthetic ultrasound-guided transperineal biopsy (LATP) is gaining popularity in this setting; however, there is uncertainty regarding prostate sampling, infection rates, tolerability, side-effects, …

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The risk of revision surgery after trainee-led primary total hip replacement

Daniel J. Howgate, Patrick Garfjeld Roberts, Antony J R Palmer, Andrew J. Price et autres

Introduction The aim of this study was to determine the impact of operating surgeon grade and level of supervision on the incidence of one-year patient mortality and all-cause revision following elective primary total hip replacement (THR). Methods National Joint Registry data from …

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Abstract 4116558: Navigator-driven Recommendations for Palliative Care Consults for Patients with Heart Failure and High Predicted Mortality

Matthew B. Anderson, Austin Lyles Seals, Amy M. Taylor, Taylor Simmons et autres

Background: Palliative care (PC) engagement can improve quality of life, reduce hospital costs, and enhance symptom control for individuals with heart failure (HF). For certain HF patients, PC can address symptoms and improve quality of life. However, referrals to PC often occur …

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Comparison of shelf-stable and conventional resuscitation products in a canine model of hemorrhagic shock

Thomas H. Edwards, Emilee C. Venn, Tuan D. Le, Lonnie E. Grantham et autres

BACKGROUND: Treatment of severe hemorrhagic shock typically involves hemostatic resuscitation with blood products. However, logistical constraints often hamper the wide distribution of commonly used blood products like whole blood. Shelf-stable blood products and blood substitutes are poised to be able to effectively …

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Protocol for open-label, randomised, controlled trial of intensive surveillance vs. standard postoperative follow-up in patients undergoing surgical resection for oesophageal and gastric cancer (SARONG trial).

Sheraz Rehan Markar, Alice Guazzelli, Amy M. Taylor, Laura Lloyd Jones et autres

TPS416 Background: Despite recent improvements in oncological and surgical treatment for patients with oesophageal and gastric cancer, 60% of patients with locally advanced disease who are treated with a curative intent will develop tumour recurrence and die within three years of completing …

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Distinct effects of AMPAR subunit depletion on spatial memory

Ahmed Eltokhi, Ilaria Bertocchi, Andrei V. Rozov, Vidar Remi Jensen et autres

Pharmacological studies established a role for AMPARs in the mammalian forebrain in spatial memory performance. Here we generated global GluA1/3 double knockout mice ( Gria1/3 −/− ) and conditional knockouts lacking GluA1 and GluA3 AMPAR subunits specifically from principal cells across the …

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CARE : Protocol of a randomised trial evaluating the feasibility of preoperative intentional weight loss to support postoperative recovery in patients with excess weight and colorectal cancer

Dimitrios A. Koutoukidis, Susan Ann Jebb, Claire L. Foster, Pete Wheatstone et autres

AIM: Excess weight increases the risk of morbidity following colorectal cancer surgery. Weight loss may improve morbidity, but it is uncertain whether patients can follow an intensive weight loss intervention while waiting for surgery and there are concerns about muscle mass loss. …

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Protocol for open-label randomized clinical trial of intensive surveillance versus standard postoperative follow-up in patients undergoing surgical resection for oesophageal and gastric cancer

Sheraz Rehan Markar, Alice Guazzelli, Amy M. Taylor, Laura Lloyd Jones et autres

Despite recent improvements in oncological and surgical treatment for patients with oesophageal and gastric cancer, 60 per cent of those with locally advanced disease who are treated with curative intent will develop tumour recurrence and die within 3 years of completing treatment. …

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18 A six year experience of a national leadership fellowship in Northern Ireland: achieve, develop, explore programme for trainees (ADEPT)

Raymond Evans, Sophie Davidson, Amy M. Taylor, M. H. H. Macartney et autres

Context The Achieve, Develop, Explore Programme for Trainees (ADEPT) Clinical Leadership Fellowship Programme was established in response to growing recommendations to underpin healthcare reconfiguration in Northern Ireland (NI) with a collective leadership strategy. This is a Clinical Leadership Fellows programme available to …