Comparison of shelf-stable and conventional resuscitation products in a canine model of hemorrhagic shock
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Le résumé fourni par la source
BACKGROUND: Treatment of severe hemorrhagic shock typically involves hemostatic resuscitation with blood products. However, logistical constraints often hamper the wide distribution of commonly used blood products like whole blood. Shelf-stable blood products and blood substitutes are poised to be able to effectively resuscitate individuals in hemorrhagic shock when more conventional blood products are not readily available. METHODS: Purpose-bred adult dogs (n = 6) were anesthetized, instrumented, and subjected to hemorrhagic shock (mean arterial pressure <50 mm Hg or 40% blood volume loss). Then each dog was resuscitated with one of five resuscitation products: (1) lactated ringers solution and hetastarch (LRS/Heta), (2) canine chilled whole blood (CWB), (3) fresh frozen plasma (FFP) and packed red blood cells (pRBC), (4) canine freeze-dried plasma (FDP) and hemoglobin-based oxygen carrier (HBOC), or (5) HBOC/FDP and canine lyophilized platelets (LyoPLT). Each dog was allowed to recover after the hemorrhage resuscitation event and was then subjected to another hemorrhage event and resuscitated with a different product until each dog was resuscitated with each product. RESULTS: At the time when animals were determined to be out of shock as defined by a shock index <1, mean arterial pressure (mmHg) values (mean ± standard error) were higher for FFP/pRBC (n = 5, 83.7 ± 4.5) and FDP/HBOC+LyoPLT (n = 4, 87.8 ± 2.1) as compared with WB (n = 4, 66.0 ± 13.1). A transient increase in creatinine was seen in dogs resuscitated with HBOC and FDP. Albumin and base excess increased in dogs resuscitated with HBOC and FDP products compared with LRS/heta and CWB ( p < 0.01). CONCLUSION: Combinations of shelf-stable blood products compared favorably to canine CWB for resolution of shock. Further research is needed to ascertain the reliability and efficacy of these shelf-stable combinations of products in other models of hemorrhage that include a component of tissue damage as well as naturally occurring trauma.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comparison of shelf-stable and conventional resuscitation products in a canine model of hemorrhagic shock
- Date Crossref
- 06/05/2024
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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United States Army Institute of Surgical Research pays non établi dans la noticeStructure de recherche
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The University of Texas at Tyler pays non établi dans la noticeUniversité ou école supérieure
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University of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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Oak Ridge Institute for Science and Education pays non établi dans la noticeUniversité ou école supérieure
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Harrison Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Utah G.L.H.) pays non établi dans la noticeUniversité ou école supérieure
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School of Veterinary Medicine From the US Army Institute of Surgical Research (T.H.E. pays non établi dans la noticeUniversité ou école supérieure
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US Army Institute of Surgical Research pays non établi dans la noticeStructure de recherche
United States Army Institute of Surgical Research, Texas A&M University et Oak Ridge Associated Universities, avec 9 autres affiliations.
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