CARE : Protocol of a randomised trial evaluating the feasibility of preoperative intentional weight loss to support postoperative recovery in patients with excess weight and colorectal cancer
Rattachement africain : gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
AIM: Excess weight increases the risk of morbidity following colorectal cancer surgery. Weight loss may improve morbidity, but it is uncertain whether patients can follow an intensive weight loss intervention while waiting for surgery and there are concerns about muscle mass loss. The aim of this trial is to assess the feasibility of intentional weight loss in this setting and determine progression to a definitive trial. METHODS: CARE is a prospectively registered, multicentre, feasibility, parallel, randomised controlled trial with embedded evaluation and optimisation of the recruitment process. Participants with excess weight awaiting curative colorectal resection for cancer are randomised 1:1 to care as usual or a low-energy nutritionally-replete total diet replacement programme with weekly remote behavioural support by a dietitian. Progression criteria will be based on the recruitment, engagement, adherence, and retention rates. Data will be collected on the 30-day postoperative morbidity, the typical primary outcome of prehabilitation trials. Secondary outcomes will include, among others, length of hospital stay, health-related quality of life, and body composition. Qualitative interviews will be used to understand patients' experiences of and attitudes towards trial participation and intervention engagement and adherence. CONCLUSION: CARE will evaluate the feasibility of intensive intentional weight loss as prehabilitation before colorectal cancer surgery. The results will determine the planning of a definitive trial.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- <scp>CARE</scp>: Protocol of a randomised trial evaluating the feasibility of preoperative intentional weight loss to support postoperative recovery in patients with excess weight and colorectal cancer
- Date Crossref
- 31/07/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Oxford Nuffield Department of Primary Care Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Oxford BioMedica (United Kingdom) pays non établi dans la noticeEntreprise
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University of Southampton Centre for Psychosocial Research in Cancer: CentRIC+ in Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Nuffield Orthopaedic Centre pays non établi dans la noticeÉtablissement de santé
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University of Bristol Population Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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NIHR Bristol Biomedical Research Centre pays non établi dans la noticeStructure de recherche
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NIHR Oxford Biomedical Research Centre Oxford UK pays non établi dans la noticeStructure de recherche
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Patient and Public Involvement Representative Leeds UK pays non établi dans la noticeInstitution
Nuffield Department of Primary Care Health Sciences — University of Oxford, Oxford BioMedica (United Kingdom) et Centre for Psychosocial Research in Cancer: CentRIC+ in Health Sciences — University of Southampton, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.