Miriam C. Keane

A Comparison Of Endothelial And Penetrating Keratoplasty In Patients With Iridocorneal Endothelial Syndrome: A Registry Study

Miriam C. Keane, Gink N. Yang, Elsie T.S. Chan, Damien G. Harkin et autres

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Enhancing registry impact: Translating registry outputs into C onsumer- F riendly I nformation (CoFI project) through consumer co-design

Sarah Eley, Caitlin Wyman, Gillian Elizabeth Caughey, Keryn A. Williams et autres

Background: Registries monitor treatment pathways and outcomes, driving healthcare improvements. However, registry outputs often target professionals, hindering consumer understanding. National strategies advocate for registries to engage in consumer co-design to develop accessible, consumer-friendly resources that empower the community to make informed decisions …

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Healthcare professionals' knowledge and attitudes towards polygenic risk testing for glaucoma

Georgina L. Hollitt, Miriam C. Keane, Thi Nguyen, Mark Hassall et autres

BACKGROUND: Effective clinical implementation of polygenic risk testing for glaucoma relies on healthcare professionals' attitudes and knowledge of the test. Given the emerging applications of the test, it will likely impact a range of healthcare professionals and will require competency in polygenic …

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Comparison of penetrating and endothelial keratoplasty in patients with iridocorneal endothelial syndrome: A registry study

Philipp K. Roberts, Miriam C. Keane, Gink N. Yang, Elsie Chan et autres

BACKGROUND: To compare graft survival of endothelial keratoplasty (EK) versus penetrating keratoplasty (PK) in patients with iridocorneal endothelial (ICE) syndrome and identify ocular features associated with graft survival. METHODS: Observational, prospective, cohort study. A total of 30 806 first grafts performed between …

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Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals

Georgina L. Hollitt, Owen M. Siggs, Bronwyn Ridge, Miriam C. Keane et autres

Purpose: Integrating polygenic risk scores (PRS) into healthcare has the potential to stratify an individual's risk of glaucoma across a broad population. Glaucoma is the most common cause of irreversible blindness worldwide, therefore effective screening for glaucoma endorsed by the population is …

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Outcomes of corneal transplantation in Australia , in an era of lamellar keratoplasty

Keryn A. Williams, Miriam C. Keane

Widespread adoption of modern lamellar procedures has altered the pattern of practice of corneal transplantation. Herein, we describe recent findings from the Australian Corneal Graft Registry and place these data into an international context. The total number of grafts reported to the …

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Attitudes Towards Polygenic Risk Testing in Individuals with Glaucoma

Georgina L. Hollitt, Owen M. Siggs, Bronwyn Ridge, Miriam C. Keane et autres

PURPOSE: Glaucoma is the leading cause of irreversible blindness worldwide; however, vision loss resulting from glaucoma generally can be prevented through early identification and timely implementation of treatment. Recently, polygenic risk scores (PRSs) have shown promise in stratifying individual risk and prognostication …

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Attitudes towards glaucoma genetic risk assessment in unaffected individuals

Georgina L. Hollitt, Owen M. Siggs, Bronwyn Ridge, Miriam C. Keane et autres

ABSTRACT Integrating polygenic risk scores (PRS) into healthcare has the potential to stratify an individual’s risk of glaucoma across a broad population. Glaucoma is the most common cause of irreversible blindness worldwide, therefore effective screening for glaucoma endorsed by the population is …

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The intravitreal injection pain study: a randomized control study comparing subjective pain with injection technique

Matthew G. Crabb, Ebony Liu, Amanda Freeman, Tim Hsu et autres

Increasing numbers of people require prolonged intravitreal anti-vascular endothelial growth factor (anti-VEGF) for retinal conditions (Stewart 2012), but the most effective peri-procedural analgesia is uncertain (Shiroma et al. 2017). We compared the efficacy of two popular techniques, subconjunctival injection (SCI) with 2% …

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DNA methylation at the 9p21 glaucoma susceptibility locus is associated with normal-tension glaucoma

Kathryn P. Burdon, Mona S. Awadalla, Paul Mitchell, Jie Jin Wang et autres

PURPOSE: Recent genome-wide association studies reported strong association of genetic variation at the CDKN2B/CDKN2B-AS1 locus on 9p21 with normal-tension glaucoma (NTG) in multiple populations. The mechanism by which this locus causes disease remains to be elucidated. We investigated the association of DNA …

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Corneal deformation dynamics are associated with the retinal nerve fiber layer progression rate in glaucoma suspects and early manifest glaucoma patients

Farshad Abedi, Antonia Kolovos, Anna M. Waldie, Jude Fitzgerald et autres

Farshad Abedi, Antonia Kolovos, Anna Waldie, Jude Fitzgerald, Mona Awadalla, Robert Casson, Stuart L Graham, Paul R Healey, Amirul Islam, Miriam Keane, John Landers, Jamie E Craig

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Is there evidence for a surgeon learning curve for endothelial keratoplasty in Australia?

Miriam C. Keane, Richard A. Mills, Douglas John Coster

Abstract Importance Expected outcomes from endokeratoplasty may vary with surgeon experience. Background It was explored whether a surgeon learning curve exists for Descemet stripping endothelial keratoplasties (manual or automated) performed in Australia. Design This is a prospective cohort study, with various clinical …

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