Helena Kullenberg

Exploring the in vitro stability of insulin degrading enzyme as a potential biomarker for neurocognitive disorders and Alzheimer's disease risk

Helena Kullenberg, Marie M. Svedberg

Insulin degrading enzyme (IDE) plays a critical role in degrading insulin and beta-forming proteins, implicating its significance as a biomarker in metabolic dysfunction and neurocognitive disorders, including Alzheimer's disease (AD). Understanding the impact of pre-analytic conditions of in vitro IDE levels is …

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Psychiatric Goals of Care at the End of Life: A Qualitative Analysis of Medical Records at a Geriatric Psychiatric Outpatient Clinic

Helena Kullenberg, Gert Helgesson, Niklas Juth, Anna Lindblad

Objectives: Person‐centered care emphasizes patient choice and autonomy and is considered an important means for improving the quality of care and quality of life for older adults with multiple chronic conditions and functional limitations. In implementing person‐centered care, goals of care based …

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Correlations between insulin-degrading enzyme and metabolic markers in patients diagnosed with type 2 diabetes, Alzheimer’s disease, and healthy controls: a comparative study

Helena Kullenberg, Jenny Rossen, Unn‐Britt Johansson, María Hagströmer et autres

PURPOSE: This study aimed to explore correlations between insulin-degrading enzyme (IDE) and markers of metabolic function in a group of patients diagnosed with type 2 diabetes mellitus (T2DM) or Alzheimer's disease (AD) and metabolically healthy volunteers. METHOD: We included 120 individuals (47 …

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Correlation between insulin-degrading enzyme versus total tau and selected cytokines in patients with Alzheimer´s disease compared to non-demented controls.

Helena Kullenberg, Thomas Nyström, Maria Kumlin, Marie M. Svedberg

OBJECTIVE: It has been increasingly recognized that the pathological progress of Alzheimer´s disease (AD) is connected to metabolic function and inflammation. Insulin-degrading enzyme (IDE) is essential for glucose metabolism and the degradation of amyloid-β. We aimed to explore the associations between IDE, …

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Associations between the Use of Metformin and Behavioral and Psychological Symptoms in Patients with Alzheimer´s Disease, and Type 2 Diabetes Mellitus – A Register-based Study

Helena Kullenberg, Moa Wibom, Maria Kumlin, Thomas Nyström et autres

BACKGROUND: Metformin, the first-line anti-diabetic drug treatment in patients with type 2 diabetes mellitus (T2DM), is suggested to be anti-inflammatory, antioxidative, and improve cognitive function, making it a promising contribution to treating Alzheimer´s disease (AD). However, the effect of metformin on behavioral …

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Increased levels of insulin-degrading enzyme in patients with type 2 diabetes mellitus

Helena Kullenberg, Jenny Rossen, Unn‐Britt Johansson, María Hagströmer et autres

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Hot saline irrigation in comparison to nasal packing after sinus surgery

Axel Nordström, Mattias Jangard, Marie M. Svedberg, Helena Kullenberg et autres

OBJECTIVES: Previous studies have shown that hot saline solution (HSS) nasal irrigation is effective against nasal bleeding and is used to treat nasal hemorrhage. In a pilot study, we evaluated hot saline nasal irrigation in comparison to a routinely used nasal packing …

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Anhörigstöd i palliativ hemsjukvård

Helena Kullenberg, Camilla Leinhard