Marie M. Svedberg

Development of 18F/11C-Labeled Pyrrolo-Pyridine/Pyrimidine LRRK2 Selective PET Radioligands

Sangram Nag, Vladimir Aleksandrovich Stepanov, Akihiro Takano, Ryosuke Arakawa et autres

Background/Objectives: Leucine-rich repeat kinase 2 (LRRK2) is an enzyme implicated in Parkinson’s disease (PD) and a potential therapeutic target. LRRK2 PET radioligands could therefore function as imaging biomarkers for PD and as tools to measure enzyme occupancy of novel therapeutic candidates. This …

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Assessment of health-related quality of life and olfactory loss in relation to nasal polyp recurrence after endoscopic sinus surgery in patients with chronic rhinosinusitis: a real life-study

Axel Nordström, Marie M. Svedberg, Michael Ryott, Maria Kumlin et autres

BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) impacts the health-related quality of life (HrQoL) and sense of smell. The association between recurrent NPs after surgery and patient-reported outcomes has not been extensively studied. OBJECTIVE: To investigate whether patients with recurrent NPs can …

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Mucosal LTE4, PGD2 and 15(S)-HETE as potential prognostic markers for polyp recurrence in chronic rhinosinusitis

Axel Nordström, Mattias Jangard, Michael Ryott, Xiao Tang et autres

BACKGROUND: Altered biosynthesis of eicosanoids is linked to type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), but their role in recalcitrant NPs is unclear. OBJECTIVES: We sought to identify endotypes that are linked to recalcitrant CRSwNP, based on eicosanoids, their …

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Exploring the in vitro stability of insulin degrading enzyme as a potential biomarker for neurocognitive disorders and Alzheimer's disease risk

Helena Kullenberg, Marie M. Svedberg

Insulin degrading enzyme (IDE) plays a critical role in degrading insulin and beta-forming proteins, implicating its significance as a biomarker in metabolic dysfunction and neurocognitive disorders, including Alzheimer's disease (AD). Understanding the impact of pre-analytic conditions of in vitro IDE levels is …

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N28 Stress and Inflammatory Bowel Disease – are there any differences during flare and remission?

Susanna Jäghult, Marie M. Svedberg, S Soto Villagran, Maria Kumlin

Abstract Background Patients with Inflammatory Bowel Disease (IBD) often experience that stress has a negative effect on the disease. Studies have also shown a possible connection between stress and active IBD. This study aims to investigate the patients´ level of stress (both …

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Correlations between insulin-degrading enzyme and metabolic markers in patients diagnosed with type 2 diabetes, Alzheimer’s disease, and healthy controls: a comparative study

Helena Kullenberg, Jenny Rossen, Unn‐Britt Johansson, María Hagströmer et autres

PURPOSE: This study aimed to explore correlations between insulin-degrading enzyme (IDE) and markers of metabolic function in a group of patients diagnosed with type 2 diabetes mellitus (T2DM) or Alzheimer's disease (AD) and metabolically healthy volunteers. METHOD: We included 120 individuals (47 …

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Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [18F]FE-PE2I-OH for Translational Dopamine Transporter Imaging

Magnus Schou, Nahid Amini, Akihiro Takano, Ryosuke Arakawa et autres

High Resolution Image Download MS PowerPoint Slide Undesired radiometabolites can be detrimental to the development of positron emission tomography (PET) radioligands. Methods for quantifying radioligand metabolites in brain tissue include ex vivo studies in small animals or labeling and imaging of the …

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Correlation between insulin-degrading enzyme versus total tau and selected cytokines in patients with Alzheimer´s disease compared to non-demented controls.

Helena Kullenberg, Thomas Nyström, Maria Kumlin, Marie M. Svedberg

OBJECTIVE: It has been increasingly recognized that the pathological progress of Alzheimer´s disease (AD) is connected to metabolic function and inflammation. Insulin-degrading enzyme (IDE) is essential for glucose metabolism and the degradation of amyloid-β. We aimed to explore the associations between IDE, …

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Distinct eicosanoid patterns in severe recalcitrant nasal polyposis

Axel Nordström, Mattias Jangard, Marie M. Svedberg, Michael Ryott et autres

Abstract Background Although altered eicosanoid levels are related to disease severity in chronic rhinosinusitis with nasal polyps (CRSwNP), identifying patients prone to recurrent nasal polyps (NPs) is still difficult. We investigated levels of nasally secreted eicosanoids before and after NP surgery in …

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Associations between the Use of Metformin and Behavioral and Psychological Symptoms in Patients with Alzheimer´s Disease, and Type 2 Diabetes Mellitus – A Register-based Study

Helena Kullenberg, Moa Wibom, Maria Kumlin, Thomas Nyström et autres

BACKGROUND: Metformin, the first-line anti-diabetic drug treatment in patients with type 2 diabetes mellitus (T2DM), is suggested to be anti-inflammatory, antioxidative, and improve cognitive function, making it a promising contribution to treating Alzheimer´s disease (AD). However, the effect of metformin on behavioral …

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Levels of eicosanoids in nasal secretions associated with nasal polyp severity in chronic rhinosinusitis

Axel Nordström, Mattias Jangard, Marie M. Svedberg, Michael Ryott et autres

in nasal secretions was not observed. In conclusion, subdividing patients based on NP severity in combination with analysis of eicosanoids in non-invasively collected nasal secretions, may have clinical implications when assessing CRS disease severity.

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Increased levels of insulin-degrading enzyme in patients with type 2 diabetes mellitus

Helena Kullenberg, Jenny Rossen, Unn‐Britt Johansson, María Hagströmer et autres

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