Tabinda Hussain

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer

Tabinda Hussain, Melrine Pereira, David Chisanga, Caleb A. Dawson et autres

au, us, fi, de (code pays fourni par la source)

LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset

Tabinda Hussain, Angela Nguyen, Daniel Thiele, Zijian Huang et autres

cells, with broad implications for immune aging and lifelong immune competence.

us, au (code pays fourni par la source)

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

Lennard Dalit, Chin Wee Tan, Amania A. Sheikh, Ryan B. Munnings et autres

Abstract CD4 + T follicular helper (T FH ) cells support tailored B cell responses against multiple classes of pathogens. To reveal how diverse T FH phenotypes are established, we profiled mouse T FH cells in response to viral, helminth and bacterial …

au, us (code pays fourni par la source)

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

Lennard Dalit, Chin Wee Tan, Amania A. Sheikh, Ryan B. Munnings et autres

SUMMARY Adaptive immune responses protect against multiple classes of pathogens, including viral, bacterial, fungal, and helminth infections. In all these settings, CD4 + T follicular helper (Tfh) cells tailor high-affinity class-switched B cells responses. How Tfh lineage sovereignty is established while allowing …

au, us (code pays fourni par la source)

Exploring the Role of TVM Cells in Age-Related CD8+ T Cell Dysfunction through ATAC-seq and RNA-seq Analysis

Daniel Thiele, Angela Nguyen, Tabinda Hussain, Adele A. Barugahare et autres

Abstract Virtual memory T (TVM) cells are a unique subset of CD8+ T cells that have both classical memory and innate-like immune function. Unlike other CD8+ T cell subsets, TVM cells are highly dependent on cytokines for their homeostasis and are selectively …

us, au (code pays fourni par la source)

Helminth Infection–Induced Increase in Virtual Memory CD8 T Cells Is Transient, Driven by IL-15, and Absent in Aged Mice

Tabinda Hussain, Angela Nguyen, Carmel P. Daunt, Daniel Thiele et autres

CD8 virtual memory T (TVM) cells are Ag-naive CD8 T cells that have undergone partial differentiation in response to common γ-chain cytokines, particularly IL-15 and IL-4. TVM cells from young individuals are highly proliferative in response to TCR and cytokine stimulation but, …

us, au (code pays fourni par la source)

Sex‐bias in CD8 + T‐cell stemness and exhaustion in cancer

Tabinda Hussain, Axel Kallies, Ajithkumar Vasanthakumar

This commentary article highlights two recently published studies, which for the first time revealed the immunological underpinnings of sex-bias in cancer incidence and mortality. These studies showed that the androgen receptor restrains anti-tumour immunity in males by repressing cytotoxic genes in CD8+ …

au (code pays fourni par la source)

Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection

Andrea Di Pietro, Jack Polmear, Lucy Cooper, Timon Damelang et autres

au, us, il (code pays fourni par la source)

Differential response of young and aged Virtual Memory CD8 T (TVM) cells to helminth-induced Th-2 cytokines

Tabinda Hussain, Angela Nguyen, Carmel P. Daunt, Daniel Thiele et autres

Abstract TVM cells are antigen-naïve, semi-differentiated CD8 T cells that develop in response to common γ (γc) chain cytokines, like IL-15 and IL-4. TVM cells respond more rapidly than conventional naïve CD8 T cells to antigen stimulation, thereby providing early control of …

us, au (code pays fourni par la source)

Hiding in Plain Sight: Virtually Unrecognizable Memory Phenotype CD8+ T cells

Daniel Thiele, Nicole L. La Gruta, Angela Nguyen, Tabinda Hussain

Virtual memory T (TVM) cells are a recently described population of conventional CD8+ T cells that, in spite of their antigen inexperience, express markers of T cell activation. TVM cells exhibit rapid responsiveness to both antigen-specific and innate stimuli in youth but …

au (code pays fourni par la source)

Publisher Correction: Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa et autres

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

us, au, de, nl (code pays fourni par la source)

Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa et autres

Abstract Virtual memory T (T VM ) cells are antigen-naïve CD8 + T cells that exist in a semi-differentiated state and exhibit marked proliferative dysfunction in advanced age. High spare respiratory capacity (SRC) has been proposed as a defining metabolic characteristic of …

us, au, de, nl (code pays fourni par la source)