Angela Nguyen

Gliadin-Specific CD4⁺ T Cells Exhibit Functional Diversity Independent of TCR Usage or Epitope Specificity

Claerwen M. Jones, Jia Jia Lim, Stefan Schattgen, Tiing Jen Loh et autres

This repository contains the single-cell data from the publication "Gliadin-Specific CD4⁺ T Cells Exhibit Functional Diversity Independent of TCR Usage or Epitope Specificity" in Science Advances.\ Celiac_noCellCyle_final.rds is the processed Seurat object. code.zip contains the code for generating and analyzing the Seurat …

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Gliadin-Specific CD4⁺ T Cells Exhibit Functional Diversity Independent of TCR Usage or Epitope Specificity

Claerwen M. Jones, Jia Jia Lim, Stefan Schattgen, Tiing Jen Loh et autres

This repository contains the single-cell data from the publication "Gliadin-Specific CD4⁺ T Cells Exhibit Functional Diversity Independent of TCR Usage or Epitope Specificity" in Science Advances.\ Celiac_noCellCyle_final.rds is the processed Seurat object. code.zip contains the code for generating and analyzing the Seurat …

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Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity

Richard Chang, Riann Jenay Egusquiza, Angélica Amorim Amato, Zhuorui Li et autres

Effects of prenatal environmental exposures can be transmitted across generations through the germline without DNA mutations, an example of transgenerational epigenetic inheritance. Understanding how such inheritance occurs remains a central unanswered question in biology. Here we show that gestational exposure of mice …

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LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset

Tabinda Hussain, Angela Nguyen, Daniel Thiele, Zijian Huang et autres

cells, with broad implications for immune aging and lifelong immune competence.

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Contributors

Sabreen Abdullah, Temitayo Adegbenro, Shahab Ahmadzadeh, Alexander Aldanese et autres

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Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

Lennard Dalit, Chin Wee Tan, Amania A. Sheikh, Ryan Munnings et autres

Abstract CD4 + T follicular helper (T FH ) cells support tailored B cell responses against multiple classes of pathogens. To reveal how diverse T FH phenotypes are established, we profiled mouse T FH cells in response to viral, helminth and bacterial …

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Ventilation Modeling of a Hen House with Outdoor Access

Hojae Yi, Eileen Fabian-Wheeler, Michael Hile, Angela Nguyen et autres

Outdoor access, often referred to as pop holes, is widely used to improve the production and welfare of hens. Such cage-free environments present an opportunity for precision flock management via best environmental control practices. However, outdoor access disrupts the integrity of the …

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1 (16A) Utility of an objective oculomotor tracking tool after multidirectional high-intensity interval training (hiit-md) in predicting clearance with return-to-play (RTP) and return-to-work (RTW) protocols in concussion patients

Amal Anilkumar, Luke Maes, Kyle Kener, Angela Nguyen et autres

Purpose RTP and RTW protocols continue to be refined and established for athletes and individuals of all ages. Tools such as objective oculomotor tracking testing (OOTT) may offer additional metrics to determine readiness for clearance testing. This study aims to investigate OOTT’s …

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56 (18B) Predominate symptom clusters in patients with persistent post concussive symptoms utilizing a validated concussion screening tool

Luke Muratalla Maes, Joseph Marshall, Amal Anilkumar, Brett Dusenberry et autres

Purpose Evaluate symptom clusters (profiles) from the validated Concussion Clinical Profile Screening Tool (CP Screen) in patients with Persistent Post Concussive Symptoms (PPCS).Methods A retrospective cross-sectional study of 184 unique subjective symptom screens were completed by patients aged 13 to 45. Patients …

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2 (21A) Vestibular sway velocity and oculomotor tracking paired to evaluate vestibulo-ocular dysfunction in concussion patients

Amal Anilkumar, Luke Maes, Kyle Kener, Jaden Todd-Nelson et autres

Purpose Force plate sway velocities (FPSV) and eye tracking serve as reliable objective markers to assess vestibulo-ocular dysfunction and aid in diagnostic/treatment decisions. This study looks to correlate FPSV to objective oculomotor tracking testing (OOTT) to discern their relationship in a patient’s …

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Sacroiliac Joint Fusion Using the Silo TFX™ Transfixing Bridge Titanium Device: Two Case Reports from the United States.

Angela Nguyen, Macie A. Serio, Hirni Patel, Azem A. Chami et autres

BACKGROUND: Sacroiliac joint (SIJ) pain is a common source of chronic low back pain, accounting for 15% to 30% in patients without disc herniation or radicular pain. Multiple advances have been made in managing SIJ pain with the development of minimally invasive …

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LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity

Justin B. Zhang, Priyanka Chaurasia, Angela Nguyen, Zijian Huang et autres

The interaction between the CD4/CD8 co-receptors and LCK (an Src family tyrosine kinase) is thought to augment T cell activation upon recognition of peptide-loaded major histocompatibility complexes (pMHCs). How this interaction influences antigen-specific T cell development is unclear however, as is its …

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