Accès ouvert
2026
article
OpenAlex
Hiromasa Ishihara, Hirofumi Shibata, Daisuke Muraoka, Ayako Demachi‐Okamura et autres
Background Human papillomavirus–positive oropharyngeal squamous cell carcinoma (HPV + OPSCC) generally has favorable outcomes yet remains prone to late recurrence. Durable control likely depends on persistent tumor-specific CD8+ T cells, but their persistence and function in metastasis are poorly understood.Methods We integrated …
jp
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Accès ouvert
2026
article
OpenAlex
Ryosuke Ikemachi, Yohei Inoue, Yoshihiro Otani, Kyohei Kin et autres
Intraparenchymal schwannomas are rare intracranial tumors confined to the brain parenchyma without connection to peripheral nerves. While conventional schwannomas are often associated with NF2 inactivation, the pathogenesis of intraparenchymal schwannomas remains poorly understood. Recent molecular studies have identified a distinct subgroup characterized …
jp
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Accès ouvert
2025
article
OpenAlex
Yasunori Fukushima, Yizheng Wang, Yuki Yada-Makino, Hiroyasu Komuro et autres
Adoptive T-cell receptor (TCR)-engineered T cell therapy is a promising approach for cancer immunotherapy, particularly for cancer/testis antigens such as KK-LC-1. We evaluated four KK-LC-1 epitope-specific TCRs restricted by Human Leukocyte Antigen (HLA)-B*15:01, including three identified by our group and one previously …
jp
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Accès ouvert
2025
conference-abstract
OpenAlex
Yasuki Suruga, Yoshihiro Otani, Atsuhito Uneda, Naoya Kemmmotsu et autres
Abstract BACKGROUND Glioblastoma (GBM) is the brain tumor with poor prognosis, despite advances in surgery, radiation, and chemotherapy. Tumor necrosis factor (TNF) signaling, particularly through TNF receptor 1 (TNFR1), has been associated with inflammation and tumor biology in GBM. However, its precise …
jp
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Accès ouvert
2025
conference-abstract
OpenAlex
Ryo Mizuta, Daisuke Muraoka, Ayako Okamura, Takanari Okamoto et autres
Abstract BACKGROUND Recently, the presence of tertiary lymphoid structure (TLS), composed mainly of intratumoral B cells, has been reported as a favorable prognostic factor in various types of cancer. However, TLS has not been well studied in glioblastoma. In this study, we …
jp, us
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Accès ouvert
2025
article
OpenAlex
Yoshihiro Otani, Joji Ishida, Ryosuke Ikemachi, Ryo Mizuta et autres
Abstract Purpose of the study: Glioblastoma is the most aggressive type of brain tumor, and the development of new treatments is urgently needed. A viral gene therapy incorporating the tumor suppressor gene REIC/Dkk-3 discovered at Okayama University was conducted from basic research …
jp, us
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Accès ouvert
2025
article
OpenAlex
Yusuke Tomita, Yoshihiro Otani, Ryo Omae, Ryo Mizuta et autres
Background: Glioblastomas (GBMs) are central nervous system tumors with a poor prognosis and limited treatment options. Although small subsets of GBM patients survive longer than 3 years, there is little evidence regarding the prognostic factors of GBM. Therefore, we conducted a thorough …
jp
(code pays fourni par la source)
2024
article
OpenAlex
Yoshihiro Otani, Fumiyo Higaki, Kentaro Fujii, Joji Ishida et autres
OBJECTIVE: The extent of resection (EOR) is an important prognostic factor for both low- and high-grade gliomas. Intraoperative MRI (iMRI) has been used to increase the EOR in glioma surgery. While a recent study reported differences between iMRI and early postoperative MRI …
jp, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Yusuke Tomita, Yoshihiro Otani, Ryo Omae, Ryo Mizuta et autres
Abstract BACKGROUND Glioblastomas (GBMs) are central nervous system tumors with a poor prognosis and limited treatment options. Although small subsets of GBM patients survive longer than 3 years, there is little evidence regarding the prognostic factors of GBM. Therefore, we conducted a …
jp, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Hiroki Kobayashi, Ryota Chijimatsu, Yusuke Naoi, Yoshihiro Otani et autres
• PBL-like lymphoma cell subpopulation is enriched in some patients with PCNSL. • This study suggests a novel rationale for using the PBL-like subpopulation as a potential therapeutic target in patients with PCNSL. Primary central nervous system lymphoma (PCNSL) is a rare, …
jp
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Accès ouvert
2024
conference-abstract
OpenAlex
Takanari Okamoto, Ryo Mizuta, Ayako Demachi‐Okamura, Daisuke Muraoka et autres
Abstract BACKGROUND The effectiveness of cancer immunotherapy against glioblastoma (GBM) remains limited. This study aims to identify cancer-specific antigens to develop antigen-based cancer immunotherapies for GBM. We investigated candidate tumor antigen-specific T cells in GBM by single-cell RNA sequencing (scRNA-seq) and single-cell …
jp
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Accès ouvert
2024
article
OpenAlex
Ryo Mizuta, Keigo Makino, Yoshihiro Otai, Kentaro Fujii et autres
Abstract BACKGROUND Although vestibular schwannoma is a benign tumor, 10% of the tumor regrow after primary tumor resection. The factors associated with tumor progression from several reports remain controversial, and the role of the tumor microenvironment in vestibular schwannoma is still unclear. …
jp, us
(code pays fourni par la source)