John C. Gore

Magical thinking and bogus science in four decades of MR imaging and spectroscopy: Some ideas on how to improve the scientific literature

John C. Gore

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A Distinct Second Spectral Peak in White Matter BOLD Signals: Mathematical Modeling, Spatial Distribution and Age-Related Evolution

Sijing Wu, Muwei Li, Yurui Gao, Lyuan Xu et autres

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Tissue Microstructural Heterogeneity Revealed by MR Microscopy

Bibek Dhakal, Benjamin M. Hardy, Xiaoyu Jiang, Adam W. Anderson et autres

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A ballooning family: A review of models of the hemodynamic response in blood oxygen level dependent (BOLD) images

Abbe L. Knutsson, John C. Gore

Mechanistic modelling of the blood oxygenation level-dependent (BOLD) response is essential for interpreting functional magnetic resonance imaging (fMRI) in physiological terms. A central framework in this literature is the balloon model, which links changes in cerebral blood flow, venous blood volume, and …

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Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus

Ning Zheng, Pai-Feng Yang, M. Anthony Phipps, Jiro Kusunose et autres

Transcranial-focused ultrasound (FUS) is a non-invasive neuromodulation technique capable of targeting deep brain regions with high precision. However, its mechanisms of action – particularly how it modulates neuronal activity and relates to fMRI BOLD signals – remain poorly understood. Using the macaque …

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Charting Cervical Spinal Cord Morphometry Across the Lifespan

Kurt Schilling, Michael E Kim, Matthew Amandola, Chenyu Gao et autres

Spinal cord morphometry provides essential biomarkers of neurological health, but clinical interpretations are confounded by inter-subject variability and a lack of normative references across the full human lifespan. We address this gap by generating the first comprehensive lifespan charts for cervical spinal …

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Anti-inflammatory treatment confirms rsfMRI and TSPO PET as biomarkers of functional connectivity and neuroinflammation in rat contusion spinal cord injuries

Chaoqi Mu, Jamie L. Reed, Feng Wang, M. Noor Tantawy et autres

A cascade of biological responses to spinal cord injury (SCI), including neuroinflammation, plays a pivotal role in determining long-term outcomes and has become a primary therapeutic target. Riluzole, a neuroprotective agent, has demonstrated efficacy in preserving tissue integrity and improving motor function …

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Early Detection of Neuroinflammation and White Matter Damage Following Dorsal Spinal Nerve Root Sectioning in a Nonhuman Primate Model

Feng Wang, John C. Gore, L. Chen

PURPOSE: Dorsal rhizotomy, or spinal dorsal nerve root lesioning, is a surgical procedure used to treat intractable nerve pain by selectively severing sensory afferent nerve roots. This study aimed to evaluate whether multiparametric MRI, including diffusion tensor imaging (DTI), quantitative magnetization transfer …

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Coaxial capacitor (COCA) coil for stretchable arrays in ultrahigh-field MRI

Ming Lu, Jason Edward Moore, John C. Gore, Xinqiang Yan

Stretchable RF coils offer the potential to improve MRI performance by conforming closely to patient anatomy, regardless of patient size, thereby enhancing both signal-to-noise ratio (SNR) and patient comfort. In this work, we investigate a stretchable receive array design based on the …

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The nature and interpretation of BOLD signals in white matter - A review

John C. Gore, Ming Li, Kurt G. Schilling, Lei Xu et autres

This review summarizes selected recent findings demonstrating the dependence of blood oxygenation level dependent (BOLD) signals in white matter (WM) on tissue microstructure, composition, vascular properties and metabolism, as well as their relationships to fMRI signals within gray matter (GM) networks. BOLD …

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White-Matter BOLD Mediates Time-Varying Cortico-Cortical Functional Connectivity

Lyuan Xu, Yurui Gao, Muwei Li, Zhongliang Zu et autres

Functional connectivity (FC) measurements in the brain using BOLD fMRI have largely focused on correlations between gray-matter (GM) BOLD signals, ignoring the possible relevance of white-matter (WM) in delineating neural networks. We first employed a tract-informed mediation framework to test whether WM …

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A practical prescription for magnetic resonance microscopy in a horizontal bore magnet

Bibek Dhakal, Benjamin M. Hardy, Adam W. Anderson, Mark D. Does et autres

Magnetic resonance microscopy (MRM) produces high spatial resolution proton images of biological tissues, plants, and porous media, revealing microstructural details and contrast unattainable by other means. A major challenge in MRM is the low signal-to-noise ratio at high spatial resolutions, as smaller …

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