Jiro Kusunose

FUS and Tactile Neuromodulation in NHP VPL - Electrophysiology

Ning Zheng, Pai-Feng Yang, M. Anthony Phipps, Jiro Kusunose et autres

This dataset contains intracranial electrophysiology recordings from the ventral posterolateral (VPL) thalamus of macaque monkeys, obtained using a NeuroNexus multi-site probe on a Blackrock Cerebus recording system. Recordings were made during focused ultrasound (FUS) neuromodulation targeted at either VPL or insular cortex, …

Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus

Ning Zheng, Pai-Feng Yang, M. Anthony Phipps, Jiro Kusunose et autres

Transcranial-focused ultrasound (FUS) is a non-invasive neuromodulation technique capable of targeting deep brain regions with high precision. However, its mechanisms of action – particularly how it modulates neuronal activity and relates to fMRI BOLD signals – remain poorly understood. Using the macaque …

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ARFI-guided Focal Localization and In Vivo Application of Focused Ultrasound for Splenic Modulation in Mice

Jixin Xia, Shannon E. Martello, Jiro Kusunose, Sofia N. Luna et autres

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Applying Ultrasound to Mechanically and Noninvasively Sensitize Prostate Tumors to TRAIL‐Mediated Apoptosis

Abigail R. Fabiano, Malachy W. Newman, Jenna A. Dombroski, Schyler J. Rowland et autres

Non-surgical and safe prostate cancer (PCa) therapies are in demand. Soluble tumor necrosis factor (TNF-α) related apoptosis inducing ligand (TRAIL), a cancer-specific drug, shows preclinical efficacy but has a short circulation half-life. This research has shown that physiological fluid shear stress activates …

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Ultrafast power doppler ultrasound enables longitudinal tracking of vascular changes that correlate with immune response after radiotherapy

Shannon E. Martello, Jixin Xia, Jiro Kusunose, Benjamin C. Hacker et autres

Rationale: While immunotherapy shows great promise in patients with triple negative breast cancer, many will not respond to treatment.Radiotherapy has the potential to prime the tumor-immune microenvironment for immunotherapy.However, predicting response is difficult due to tumor heterogeneity across patients, which necessitates personalized …

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Design of an Array Transducer for Localizing Microbubble Activity Through the Skull

Malachy W. Newman, Jiro Kusunose, M. Anthony Phipps, Allison Q Dockum et autres

Transcranial focused ultrasound is an important tool for opening the blood brain barrier (BBB), which is typically performed by focusing ultrasonic energy through the skull into regions that have been perfused with microbubbles (MB). When sonicated, these MB oscillate and temporarily disrupt …

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Image Guidance of a Phased Array Transducer for Neuromodulation with a Small Focal Volume

Allison Q Dockum, M. Anthony Phipps, Malachy W. Newman, Jiro Kusunose et autres

Transcranial focused ultrasound (tFUS) can modulate the brain using neuronavigation systems that guide where tFUS is delivered. However, neuronavigation systems can have up to 3-mm of targeting error. Previous tFUS systems have circumvented these targeting errors by using transducers with large focal …

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Design and Validation of a Patient-Specific Stereotactic Frame for Transcranial Ultrasound Therapy

Jiro Kusunose, Huiwen Luo, Thomas J. Manuel, M. Anthony Phipps et autres

Transcranial-focused ultrasound (tFUS) procedures such as neuromodulation and blood-brain barrier (BBB) opening require precise focus placement within the brain. MRI is currently the most reliable tool for focus localization but can be prohibitive for procedures requiring recurrent therapies. We designed, fabricated, and …

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Ultrasound Modulates Calcium Activity in Cultured Neurons, Glial Cells, Endothelial Cells and Pericytes

Malachy W. Newman, Pratheepa Kumari Rasiah, Jiro Kusunose, Tonia S. Rex et autres

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Growth factor free, peptide-functionalized gelatin hydrogel promotes arteriogenesis and attenuates tissue damage in a murine model of critical limb ischemia

C. Curry, Sarah M. Sturgeon, Brian J. O’Grady, Alexis K. Yates et autres

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Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array

Thomas J. Manuel, Michelle K. Sigona, M. Anthony Phipps, Jiro Kusunose et autres

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Ultrafast Power Doppler Ultrasound Enables Longitudinal Tracking of Vascular Changes that Correlate with Immune Response After Radiotherapy

Shannon E. Martello, Jixin Xia, Jiro Kusunose, Benjamin C. Hacker et autres

Abstract Background While immunotherapy shows great promise in patients with triple negative breast cancer, many will not respond to treatment. Radiotherapy has the potential to prime the tumor-immune microenvironment for immunotherapy. However, predicting response is difficult due to tumor heterogeneity across patients, …

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