Sheila Riazi

Direct-to-Phase II recovery after hip and knee arthroplasty at Toronto Western Hospital

Chiara A. Arena, Michael G. Zywiel, Sheila Riazi, Alexandra Boasie et autres

ca (code pays fourni par la source)

Genotype–phenotype relationships in butyrylcholinesterase deficiency: a systematic review

Cezar D. Snak de Souza, Carlos A. Moreno, Sheila Riazi, Philip F. Hopkins

ca, gb (code pays fourni par la source)

A proposed North American approach for genetic testing of individuals at risk for malignant hyperthermia

Sheila Riazi, Stacey Watt, Jennifer Plester, Leslie G. Biesecker

Malignant hyperthermia, a pharmacogenetic disorder of skeletal muscle, is a potentially fatal reaction triggered by exposure to volatile anesthetics or succinylcholine. Genetic testing of the three known involved genes (RYR1, CACNA1S, and STAC3) has become the first line of testing for malignant …

ca, us (code pays fourni par la source)

A Proposed North American Approach for Genetic Testing of Individuals at Risk for Malignant Hyperthermia

Sheila Riazi, Stacey Watt, Jennifer C. Plester, Leslie G. Biesecker

Malignant hyperthermia, a pharmacogenetic disorder of skeletal muscle, is a potentially fatal reaction triggered by exposure to volatile anesthetics or succinylcholine. Genetic testing of the three known involved genes (RYR1, CACNA1S, and STAC3) has become the first line of testing for malignant …

ca, us (code pays fourni par la source)

Humidity impacts volatile anesthetic and heat responses of malignant hyperthermia susceptible mice

Miao He, Sheila Riazi, Luuk R. van den Bersselaar, Gunilla Islander et autres

BACKGROUND: Malignant Hyperthermia (MH) is characterized by life-threatening whole-body hyperthermic reactions triggered by volatile anesthetics in susceptible individuals. MH susceptibility (MHS) and exertional heat stroke (EHS) are linked to mutations in the type I ryanodine receptor (RYR1). However, the discordance between the …

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Aberrant Intracellular Calcium Homeostasis Disrupts Insulin-stimulated Glucose Uptake in Muscle Cells from Patients with Malignant Hyperthermia Susceptibility

Arkady Uryash, Iqra Abdul Razzaq, Carlos A. Moreno, José A. Adams et autres

us, ca (code pays fourni par la source)

Age‐Dependent Effects of Muscle Resting Calcium on Fasting Blood Glucose: Implications for Prediabetes Risk

Eshwar R. Tammineni, Lourdes Figueroa, Michael Fill, Sheila Riazi et autres

ABSTRACT Background and Aims Skeletal muscle is the primary site for insulin‐mediated glucose uptake and is critical in maintaining whole‐body glucose homeostasis. Muscle cells from malignant hyperthermia‐susceptible (MHS) individuals exhibit elevated resting cytosolic calcium concentration ([Ca2+]cyto), and MHS subjects have a higher …

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Malignant Hyperthermia

Teeda Pinyavat, Sheila Riazi, Jiawen Deng, Marat Slessarev et autres

OBJECTIVES: A narrative expert review aiming to summarize the clinical epidemiology and management of critically ill patients with malignant hyperthermia (MH). DATA SOURCES: Medline searches were conducted to identify relevant articles describing the epidemiology, pathophysiology, and management of MH. Guidelines from key …

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Myopathic manifestations across the adult lifespan of patients with malignant hyperthermia susceptibility: a narrative review

Carlos A Ibarra, Helga Cristina Almeida da Silva, Nicol C. Voermans, Heinz Jungbluth et autres

Malignant hyperthermia susceptibility (MHS) designates individuals at risk of developing a hypermetabolic reaction triggered by halogenated anaesthetics or the depolarising neuromuscular blocking agent suxamethonium. Over the past few decades, beyond the operating theatre, myopathic manifestations impacting daily life are increasingly recognised as …

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Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Eduardo Rı́os, Montserrat Samsó, Lourdes Figueroa, Carlo Manno et autres

Skeletal muscle, the major processor of dietary glucose, stores it in myriad glycogen granules. Their numbers vary with cellular location and physiological and pathophysiological states. AI models were developed to derive granular glycogen content from electron-microscopic images of human muscle. Two UNet-type …

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Acute effects of dantrolene on the mechanical performance of myopathic human hearts

Praloy Chakraborty, Mahmoud Bokhari, Stéphane Massé, Mohammed Ali Azam et autres

ca (code pays fourni par la source)

Deep learning convolutional neural networks for the quantification of glycogen in electron micrographs of calcium-stressed human muscle

Eduardo Rı́os, Montserrat Samsó, Eshwar R. Tammineni, Lourdes Figueroa et autres

us, ca (code pays fourni par la source)