Eduardo Rı́os

Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail

Eduardo Rı́os, Gonzalo Pizarro

This modeling study explains the intracellular Ca2+ release that controls contraction of skeletal muscles of mammals as emerging from a statistical ensemble of couplons. Couplons are constituted by identical sarcoplasmic reticulum RyR1 channels, arranged in native "checkerboard" double-row pattern, with alternate channels …

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Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Eduardo Rı́os

This study reveals an examination of the phenomenon of coupled gating between ryanodine receptors, the Ca2+ channels of the sarcoplasmic reticulum of skeletal and cardiac muscle, essential for the execution of contraction upon electrical excitation. It asks whether the phenomenon-pairs of channels …

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Cardiorespiratory effects of adding adrenaline to arthroscopic irrigation fluid on improvement of clarity of visual field in dogs

Agustín G. Zapata, Eduardo Rı́os, Rocío Fernández

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Using neural networks for image analysis in general physiology

Eduardo Rı́os

An article with three goals, namely, to (1) provide the set of ideas and information needed to understand, at a basic level, the application of convolutional neural networks (CNNs) to analyze images in biology; (2) trace a path to adopting and adapting, …

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Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Eduardo Rı́os, Montserrat Samsó, Lourdes Figueroa, Carlo D. Manno et autres

Skeletal muscle, the major processor of dietary glucose, stores it in myriad glycogen granules. Their numbers vary with cellular location and physiological and pathophysiological states. AI models were developed to derive granular glycogen content from electron-microscopic images of human muscle. Two UNet-type …

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Deep learning convolutional neural networks for the quantification of glycogen in electron micrographs of calcium-stressed human muscle

Eduardo Rı́os, Montserrat Samsó, Eshwar Reddy Tammineni, Lourdes Figueroa et autres

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Distinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia

Lourdes Figueroa, Natalia Kraeva, Carlo D. Manno, Carlos A. Ibarra-Moreno et autres

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Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation

Eshwar Reddy Tammineni, Lourdes Figueroa, Carlo D. Manno, Disha Varma et autres

Calcium ion movements between cellular stores and the cytosol govern muscle contraction, the most energy-consuming function in mammals, which confers skeletal myofibers a pivotal role in glycemia regulation. Chronic myoplasmic calcium elevation (“calcium stress”), found in malignant hyperthermia-susceptible (MHS) patients and multiple …

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Author response: Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation

Eshwar Reddy Tammineni, Lourdes Figueroa, Carlo D. Manno, Disha Varma et autres

Novel components in the pathway from malignant hyperthermia to diabetes include promotion of a kinase that impedes glycogen synthesis, increased lysis of junctophilin1 and gene regulatory actions by a junctophilin fragment, surprisingly predicted to oppose the effects of elevated calcium.

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Excitation–contraction coupling in cardiac, skeletal, and smooth muscle

Robert T. Dirksen, David A. Eisner, Eduardo Rı́os, Karin R. Sipido

status: Published

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A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes

Carlo D. Manno, Eshwar Reddy Tammineni, Lourdes Figueroa, Yuriana Oropeza‐Almazán et autres

This work describes a simple way to identify fiber types in living muscles by fluorescence lifetime imaging microscopy (FLIM). We quantified the mean values of lifetimes τ1 and τ2 derived from a two-exponential fit in freshly dissected mouse flexor digitorum brevis (FDB) …

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Raw image sets for "Junctophilin 1 and calcium stress"

Eduardo Rı́os

Raw images of fluorescence used to generate processed images in the article.

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