Debaraj Mukherjee

A Journey from Traditional to Photoredox-Induced C-Glycosylations

Ramanand Das, Pema Renchen Sherpa, Sanchari Kundu, Taraknath Kundu et autres

Abstract C-Glycosylation is regarded as one of the most powerful tools for synthesizing biologically potent molecules, where specific control over the anomeric selectivity has remained a major synthetic hurdle. Recently discovered approaches of radical glycosylations through metallo- and organo-catalyzed photoredox reactions has …

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Acid-Catalyzed Synthesis of C-6-Esterified Sugar Acceptors from Acetals/Ketals Using Esters as Acyl Donors

Rahul Haldar, Sanchari Kundu, Debaraj Mukherjee

A H 2 SO 4 –silica/TfOH-catalyzed regioselective primary esterification of acetal/ketal-protected glycosides has been developed. 4,6- O -Benzylidene-protected glycosides reacted smoothly with esters, which served as both solvent and acylating agent, to afford C-6-esterified orthogonally protected sugar acceptors. This transformation was also …

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Regioselective primary acylation of glycosides using esters as an acylating agent: synthesis of orthogonally protected sugar building blocks

Rahul Haldar, Sanchari Kundu, Amit Ghosh, Debaraj Mukherjee

A green protocol for the regioselective acylation of the free primary hydroxyl groups in glycosides was developed using esters as both the acylating agent and solvent at room temperature, affording products in excellent yields without generating acidic waste. Some important oligosaccharide building …

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Photocatalyst-Free 1,2- vic Elimination toward the Synthesis of 4,6- O -Protected Glycals under Visible Light

Sanchari Kundu, Ramanand Das, Rahul Haldar, Zernain Sultana et autres

A photocatalyst-free vicinal elimination of 1,2-functionalized pyranoses has been developed using a mild base such as triethylamine (Et 3 N). This method enables the synthesis of synthetically challenging 4,6- O -protected unsaturated sugars from readily accessible 2-deoxy-2-haloglycopyranosyl azides. The reaction proceeds under …

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Synthesis and antibacterial evaluation of trisindolines against methicillin-resistant Staphylococcus aureus targeting cell membrane

Arti Rathore, Irshad Ahmad Zargar, Jyoti Kumari, Biplab Sarkar et autres

Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant global health threat that requires novel antimicrobials to combat this WHO-designated priority pathogen. In this study, we designed, synthesized and evaluated a series of unexplored trisindoline derivatives against MRSA, including multidrug-resistant (MDR) clinical isolates. The …

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Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Kaja Abbas et autres

BACKGROUND: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital …

Roles of Allopathic Medicines to Treat SARS‐CoV‐2 Pathogen Causing COVID‐19

Norein Sakander, Bisma Rasool, Ajaz Ahmed, Debaraj Mukherjee et autres

A newly emerging viral illness known as coronavirus disease 2019 (COVID-19) is classified as a typical pneumonia brought on by coronavirus-2 causing severe acute respiratory syndrome (SARS-CoV-2). It was initially discovered in Wuhan, China, and, after spreading to other parts of the …

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Author response for "Room-temperature synthesis of 3-keto-C-disaccharides from unprotected glycal donor via palladium-catalysed Heck-type reaction"

Bisma Rasool, Irshad Ahmad Zargar, Shweta Gulabchand Gadecha, Qazi Naveed Ahmed et autres

N-Heterocyclic Carbene-Catalyzed Transformation of Formyl Sugars to Deoxy-Sugar Lactones

Norein Sakander, Shweta Gulabchand Gadecha, Irshad Ahmad Zargar, Narendra Nath Ghosh et autres

-heterocyclic carbenes (NHCs) in catalyzing the transformation of sugar aldehydes into deoxy-sugar lactones has been systematically investigated. Imidazolium-derived NHCs efficiently facilitated the conversion of both pyranose- and furanose-based sugar aldehydes through the formation of Breslow intermediates, offering a mechanistically distinct and stereoselective …

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Author response for "Room-temperature synthesis of 3-keto-C-disaccharides from unprotected glycal donor via palladium-catalysed Heck-type reaction"

Bisma Rasool, Irshad Ahmad Zargar, Shweta Gulabchand Gadecha, Qazi Naveed Ahmed et autres

Identification and functional characterization of a cold-inducible UDP-Glycosyltransferase (GgUGT72L11) from Glycyrrhiza glabra

Shahnawaz Hussain, Bhawna Verma, Malik Muzafar Manzoor, Pooja Goyal et autres

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Visible Light-Promoted Ir(III)-Catalyzed Stereoselective Synthesis of Azauracil-C-Nucleosides from 1-Bromosugar

Ramanand Das, Norein Sakander, Sanchari Kundu, Debaraj Mukherjee et autres

A visible light-promoted, mild, and efficient Ir(III)-catalyzed synthesis of C -nucleosides is reported, utilizing 1-bromosugar as the glycosyl radical precursor and 6-azauracil as the nucleobase. The method exhibits high α-selectivity and excellent functional group tolerance. Spectroscopic evidence shows that the coupling reaction …

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