Peter Grün

Total Synthesis and Structural Revision of Rhabdobranin Reveals a Cryptic Gram-Negative Antibiotic

Woonkee S. Jo, Zaynoun Attieh, Jan J. Crames, Carl Leonhard Knopp et autres

Gram-negative bacteria present a major clinical challenge but also remain an underexplored source of antibacterial natural products. Resistance-guided genome mining of the entomopathogenic symbiont Xenorhabdus identified the rdb biosynthetic gene cluster, which encodes a putative prodrug antibiotic, pre-rhabdobranin. However, the inability to …

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Pseudotetraivprolide aus Pseudomonas entomophila liefern Einblicke in die Biosynthese von Detoxin/Rimosamid‐ähnlichen Anti‐Antibiotika

Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi et autres

Zusammenfassung Die Entdeckung neuer Varianten bekannter Naturstoffe ermöglicht oft wertvolle Einblicke in die Biosynthese und Wirkmechanismen der gesamten Substanzklasse. Hier beschreiben wir neue Vertreter der weit verbreiteten Detoxin/Rimosamid‐ähnlichen (DRL) Naturstoffe, genannt Pseudotetraivprolide, die von Pseudomonas ‐Stämmen produziert werden. Pseudotetraivprolide weisen die charakteristische …

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Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics

Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi et autres

Novel variants of known natural product (NP) classes can provide valuable insights into their biosynthesis, mechanisms of action, and potential as drug leads across the entire class. Here, we describe a novel member of the widespread detoxine/rimosamide-like (DRL) natural products, named pseudotetraivprolide, …

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Characterization of six bioactive compounds from two soil-derived Streptomyces strains, F9 and F4 from Iran

Sara Ghashghaei, Helge B. Bode, Zahra Etemadifar, Yan‐Ni Shi et autres

Background and purpose: Actinobacteria are highly valuable in the pharmaceutical industry due to their unlimited capacity to produce natural products. In line with the screening of actinomycetes to discover new antibacterial agents, this study isolated and elucidated bioactive compounds from two Streptomyces …

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Effect of titanium in-situ alloying on the microstructure and mechanical properties of the RHEAs MoNbTaW system

Bernardo L. Ribeiro, Peter Grün, Filofteia-Laura Toma, Leonid Gerdt et autres

:Refractory High-Entropy Refractory Alloys (RHEAs) are emerging as potential alternatives to Ni-based superalloys due to their exceptional high-temperature properties. Among them, the MoNbTaW system shows promising characteristics, though brittleness at room temperature limits practical use. In the present study, the titanium (Ti) …

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Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues

Ли Су, Souaibou Yaouba, Laurence Hôtel, Christophe Jacob et autres

was transplanted into a different PKS module, suggesting a critical role for domain context in the overall functioning of PKS proteins. We also demonstrate the superiority of this mutasynthesis approach - both in terms of absolute titers and yields relative to the …

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Correction: Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues

Ли Су, Souaibou Yaouba, Laurence Hôtel, Christophe Jacob et autres

Correction for ‘Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues’ by Li Su et al. , Chem. Sci. , 2025, https://doi.org/10.1039/d4sc06976e.

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Author response for "Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues"

Ли Су, Souaibou Yaouba, Laurence Hôtel, Christophe Jacob et autres

Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues

Ли Су, Souaibou Yaouba, Laurence Hôtel, Christophe Jacob et autres

Abstract The polyketide specialized metabolites of bacteria are attractive targets for generating analogues, with the goal of improving their pharmaceutical properties. Here, we aimed to produce C-26 derivatives of the giant anti-cancer stambomycin macrolides using a mutasynthesis approach, as this position has …

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Pyrrolizwilline, a Unique Bacterial Alkaloid Assembled by a Nonribosomal Peptide Synthetase and non‐Enzymatic Dimerization

Juliana Effert, Margaretha Westphalen, Andrea Calderari, Yi‐Ming Shi et autres

Pyrrolizidine alkaloids (PAs) are a structurally diverse group of heterocyclic specialized metabolites characterized by a core structure comprising a hexahydro-1H-pyrrolizine. PAs are synthesized through two main pathways. In plants, assembly occurs via a homospermidine synthase, and in bacteria, through combined action of …

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Pyrrolizwillin, ein Einzigartiges Bakterielles Alkaloid, Gebildet durch eine Kombination aus Nichtribosomaler Peptidsynthetase und nicht‐Enzymatischer Dimerisierung

Juliana Effert, Margaretha Westphalen, Andrea Calderari, Yi‐Ming Shi et autres

Abstract Pyrrolizidinalkaloide (PAs) sind eine strukturell vielfältige Gruppe spezialisierter heterocyclischer Metabolite, die durch eine Hexahydro‐1 H ‐pyrrolizin‐Kernstruktur charakterisiert werden. PAs werden über zwei unterschiedliche Biosynthesewege gebildet. In Pflanzen werden sie durch eine Homospermidinsynthase synthetisiert, während sie in Bakterien durch die kombinierte Wirkung …

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Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification

Ли Су, Eva Maria Huber, Margaretha Westphalen, Jonas Gellner et autres

Dithiolopyrrolone (DTP) natural products are produced by several different bacteria and have potent antibacterial, antifungal and anticancer activities. While the amide of their DTP core can be methylated to fine-tune bioactivity, the enzyme responsible for the amide N-methylation has remained elusive in …

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