Wanlu Li

Gaseous liquid nitrogen–assisted cryo-printing strategies for challenging volumetric anisotropic tissues fabrication

Zhiqiang Gao, Wanlu Li, Zeyu Luo, Xinhan Liu et autres

Engineering physiologically relevant anisotropic tissues remains a major challenge due to limitations in replicating native structural cues across complex geometries. Here, we developed a cryogenic extrusion bioprinting platform by precisely guiding ice crystal growth to achieve centimeter-scale anisotropic constructs, even with ultrasoft, …

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A phase II, single-arm trial of adebrelimab plus nab-paclitaxel and carboplatin as first-line therapy for advanced thymic carcinoma: Interim efficacy and safety results.

Ning Xu, Yang Chen, Zhiqiang Gao, C Wang et autres

e20171 Background: Thymic carcinoma (TC) is a rare and aggressive malignancy with poor prognosis in advanced stages. Given the limited efficacy of standard first-line regimen (carboplatin/paclitaxel), there remains an urgent unmet need for novel treatment approaches. This study evaluated the efficacy and …

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Targeted Inhibition of MEGF10 ‐Mediated Astrogliosis Reduces Glial Scar Formation and Promotes Neurofunction Recovery in Mice After Stroke

Jing-Jing Xu, Tongtong Xu, Lin Gan, Shiyu Deng et autres

The formation of glial scar at the chronic stage of neurological disease is mainly attributed to the activation and proliferation of astrocytes, termed astrogliosis. It is documented that astrogliosis-induced glial scar formation following stroke severely impairs neurological recovery. However, the mechanisms underlying …

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Immuno‐Training Remodeled Vascular Microenvironment via Peptide‐Functionalized Hydrogel Microspheres for Neural Repair

Lin Gan, Tongtong Xu, Dandan Zheng, Ning Zhu et autres

ABSTRACT The vascular hyperinflammatory microenvironment significantly influences the regeneration and repair of central nervous system (CNS) following injury. Training immune behavior of immune cells under stress conditions is crucial for maintaining vascular microenvironment homeostasis and restoring vascular function. In this study, we …

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Piezo1 induces Wnt7b + astrocytes transformation to modulate glial scar stiffness and neuro-regeneration after stroke

Shengju Wu, Wenjie Hao, Qian Suo, Q. W. Lu et autres

Background: Reactive astrocytes form a chemical and mechanical glial scar that inhibits neuro-regeneration after stroke.Astrocyte heterogeneity is accompanied by changes in morphology and mechanical properties altering during scar formation after injury.This work aimed to elucidate the relationship between glial scar stiffness and …

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Injectable micropore-forming microgel scaffold for neural progenitor cells transplantation and vascularization after stroke

Huayan Wu, Ze Liu, Zijie Zhang, Zhongqing Liu et autres

Stem cell therapy for stroke is hindered by poor cell survival and integration within the ischemic microenvironment. Injectable microgels have been widely employed in cell delivery for their ability to promote cell infiltration, but dense hydrogel networks often limit cell survival. Here …

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Lipid Nanoparticle-Mediated Targeted Delivery of MEGF10 siRNA to Astrocytes Reduced Synaptic Phagocytosis and Promoted Stroke Recovery in Mice

Tongtong Xu, Yan Chang, Jingjing Xu, Dongliang Qian et autres

Astrocyte-mediated synaptic phagocytosis plays a critical role in regulating brain development and disease progression. Our previous studies have demonstrated that MEGF10, a key molecule mediating astrocytic phagocytosis of synapses, is remarkably upregulated during the chronic phase of stroke, leading to synapse loss …

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Microgels for 3D Biofabrication

Ting Xie, Huaibin Wang, Jieting Li, Leyan Xuan et autres

ABSTRACT While traditional bulk hydrogels have been widely used in 3D bioprinting for tissue engineering, engineered cell‐loaded scaffolds still fall short of expectations because their nanoscale molecular networks impede cell function. Microgels, as micron‐sized hydrogel materials, offer significant advantages in enhancing mass …

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Dual‐Functionalized Extracellular Vesicles Promote Brain Repair and Remodeling Following Ischemic Stroke in Mice

Victoria Shi, Shengju Wu, Qianyuan Lian, Rubing Shi et autres

BACKGROUND: Ischemic stroke remains a leading cause of long-term disability and mortality worldwide, with few effective treatment options. A key challenge in recovery is the brain's limited capacity to regenerate neurovascular structures after injury. To address this, we developed a dual-functionalized extracellular …

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Supplementary Data 1 from Antitumor Immunity Mediated by Engineered Stem Cells Exploiting TRAIL-Induced Cell Death and FLT3L Immunomodulation

Thijs van Schaik, Kok‐Siong Chen, Nobuhiko Kanaya, Lucia Moreno-Lama et autres

Supplementary Figures and Legends

Data from Antitumor Immunity Mediated by Engineered Stem Cells Exploiting TRAIL-Induced Cell Death and FLT3L Immunomodulation

Thijs van Schaik, Kok‐Siong Chen, Nobuhiko Kanaya, Lucia Moreno-Lama et autres

AbstractPurpose: Death receptor (DR)–targeted therapies offer a promising tumor cell–specific therapeutic strategy for highly malignant brain tumors, such as glioblastoma (GBM). However, whether DR-mediated cell death leads to activation of the adaptive immune system and impacts the tumor immune microenvironment (TIME) remains …

Advice and Tips for Achieving Work-Life Balance for Early Career Researchers

Muyassar Mamtilahun, Mian Wang, Wanlu Li

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