Leyan Xuan

Volumetric Bioprinting of Aqueous Two-Phase Emulsion Bioinks Enables High-Fidelity Macroporous Hydrogel Scaffolds for Volumetric Muscle Loss Repair

Guosheng Tang, y hou, Long Chen, Jieting Li et autres

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Scalable and oil-free fabrication of monodisperse microgels via all-aqueous microfluidics

Jialin Wu, Long Chen, Changyi Xiao, Leyan Xuan et autres

While traditional microfluidics approaches achieve considerable success in microgel production, surfactant- and oil-free fabrication of monodisperse microgels remains challenging. Here, we present a simple one-step strategy that uses water-in-water (W/W) aqueous two-phase systems (ATPSs) to enable scalable production of monodisperse microgels without …

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Bioenzymatic single-cell microencapsulation for enhanced stem Cell therapy

Leyan Xuan, T.-H. Lu, Yingying Hou, Yuguang Zhu et autres

Cell therapy has achieved a critical breakthrough through single-cell microgel technology. This miniaturized encapsulation platform enables precise microenvironment recapitulation, efficient targeted delivery, and tunable pericellular matrix control. Nevertheless, prevailing microfluidic and surface chemical engineering methodologies confront fundamental challenges in preserving cell viability …

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Microgel‐Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction

Ziyang Liu, Leyan Xuan, Yingying Hou, Ting Xie et autres

While there has been considerable success in the 3D bioprinting of hydrogel scaffolds for tissue engineering, the application of traditional centimeter-scale bulk hydrogels with a dense internal nanoscale network structure remains a particular challenge. Here, we present a microgel-based modular fabrication strategy …

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Physiological-cell-density 3D bioprinting: Advancing tissue constructs for near-native function

Leyan Xuan, Jieting Li, Bingbing Zhan, Jialin Wu et autres

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Microgels for 3D Biofabrication

Ting Xie, Huaibin Wang, Jieting Li, Leyan Xuan et autres

ABSTRACT While traditional bulk hydrogels have been widely used in 3D bioprinting for tissue engineering, engineered cell‐loaded scaffolds still fall short of expectations because their nanoscale molecular networks impede cell function. Microgels, as micron‐sized hydrogel materials, offer significant advantages in enhancing mass …

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Fishing out AIEC with FimH capturing microgels for inflammatory bowel disease treatment

Jialin Wu, Yutao Liu, Ruiying Liu, Xiao Changyi et autres

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition with rising global incidence and limited treatment options. Current therapies often have poor efficacy and undesirable side effects. Here we present a drug-free strategy that targets bacterial adhesion to manage IBD. We develop …

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Superparamagnetic hydrogels: Precision-driven platforms for biomedicine, robotics, and environmental remediation

Huaibin Wang, Yingying Hou, Long Chen, Wenjian Mo et autres

Hydrogels are widely recognized for their biocompatibility and structural adaptability in regenerative medicine and three-dimensional (3D) bioprinting, yet their inherent static nature fundamentally limits applications demanding dynamic spatiotemporal control. The incorporation of superparamagnetic iron oxide nanoparticles (SPIONs) addresses this issue. The incorporation …

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Anisotropic Microcarriers: Fabrication Strategies and Biomedical Applications

Yingying Hou, Leyan Xuan, Wenjian Mo, Ting Xie et autres

Anisotropic microcarriers (AMs) have attracted increasing attention. Although significant efforts have been made to explore AMs with various morphologies, their full potential is yet to be realized, as most studies have primarily focused on materials or fabrication methods. A thorough analysis of …

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Fabrication of Single-Bacterium Microgel with Gas-Shearing Strategy for Precision Probiotic Delivery in IBD Therapy

Jialin Wu, Li Wu, Ruiying Liu, Leyan Xuan et autres

The human gut microbiome is essential for maintaining health, as it substantially impacts immune regulation and overall balance within the body. Accordingly, disruptions in this microbial community are associated with various diseases. Probiotics offer a promising solution, but their effectiveness is often …

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3D Biofabrication of Microporous Hydrogels for Tissue Engineering

Ziyang Liu, Jialin Wu, Zeyu Luo, Yingying Hou et autres

Microporous hydrogels have been utilized in an unprecedented manner in the last few decades, combining materials science, biology, and medicine. Their microporous structure makes them suitable for wide applications, especially as cell carriers in tissue engineering and regenerative medicine. Microporous hydrogel scaffolds …

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Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine

Leyan Xuan, Yingying Hou, Lu Liang, Jialin Wu et autres

Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells or drug carriers, that are promising for tissue engineering and regenerative medicine. Microgels can also be aggregated into microporous scaffolds, promoting cell infiltration and proliferation for tissue …

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