Arpita Patel

Preclinical development of SL-325, a novel high-affinity DR3-blocking antibody for durable inhibition of the DR3/TL1A axis in inflammatory bowel disease

Mahmud Hussain, Anne Y. Lai, Derek Franklin, Karen L. Lenz et autres

BACKGROUND: Death receptor 3 (DR3; also termed tumor necrosis factor receptor superfamily member 25 [TNFRSF25]) is the sole functional receptor for tumor necrosis factor (TNF)-like cytokine 1A (TL1A) and is constitutively expressed on effector lymphoid cells in peripheral blood and in both …

Hypomagnesemia is Linked with a Higher Risk of Long Bone Fractures: A Cross-sectional Study

Neeti Patel, Kandarp Patel, Arpita Patel, Nidhi R Purandare

A compact quad-port dielectric resonator MIMO antenna with intrinsic isolation for sub-6 GHz 5G network

Arpita Patel, Trushit Upadhyaya, Rajat Pandey, Upesh Patel et autres

Abstract This paper presents the systematic design, fabrication, and experimental validation of a compact quad-port dielectric resonator antenna (DRA)–based MIMO system for sub-6 GHz 5G applications. An aperture-fed excitation combined with optimized spatial arrangement is employed to achieve high inter-port isolation intrinsically, …

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Cutaneous Neuro-Immune Interactions in Chronic Itch and the Role of TRP Channels in Emerging Therapies

Rachel Santana Felipes, Allison Meihofer, Arpita Patel, Natalie Rose Asemi et autres

The interplay between the cutaneous nervous and immune systems plays a notable role in the pathogenesis of chronic itch, a debilitating symptom associated with conditions such as atopic dermatitis, psoriasis, and prurigo nodularis. Recent advances in neuro-immune biology have discovered the importance …

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SAT-643 Type 2 Diabetes Mellitus and Metformin: Double Trouble Causing Peripheral Neuropathy?

Jaya M Pathak, Nritya Brijesh Trivedi, Apurva Patel, Anushri Parikh et autres

Abstract Disclosure: S.B. Karatela: None. J.M. Pathak: None. N.B. Trivedi: None. K.P. Shah: None. D.J. Shah: None. A.G. Patel: None. A. Parikh: None. A.J. Rajani: None. A. Patel: None. Type 2 diabetes mellitus (T2DM) is a growing global health concern, with complications …

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On-board electrically small diplexer for future radio science planetary RF subsystem applications

Trushit K. Upadhyaya, Jayesh Pabari, Arpita Patel, Upesh Patel et autres

• Developed an electrically small microstrip diplexer with compact dimensions (0.6 λ × 0.511 λ). • Achieved high port isolation (>30 dB) for dual frequencies, critical for RF subsystem performance. • Designed tailored intrinsic filters with multiple transmission zeros for superior stopband …

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Impact of Frailty on Mortality and Discharge Outcomes in Critically Ill Patients: A Systematic Review and Meta-analysis

John Muscedere, N. Koert van der Linden, Martin Albert, Patrick Michel Archambault et autres

Abstract Rationale: Critical illness in patients living with frailty has been reported to be associated with poor health outcomes. Understanding its impact on key outcomes such as mortality, and function is crucial for guiding care strategies and informed shared decision-making in this …

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Fluid Resuscitation Compliance and Vasopressor Outcomes in Septic Shock: A Study of BPA-driven Management

W. Wallach, Arpita Patel, Christine A. Henry, Lloyd Muzangwa et autres

Abstract Evaluate the adherence to BPA alert instructions based on the Surviving Sepsis Campaign guidelines for treating septic shock. Septic shock is characterized by hypotension and organ dysfunction resulting from systemic infection. The Surviving Sepsis Campaign provides evidence-based guidelines for the early …

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High‐Resolution National‐Scale Water Modeling Is Enhanced by Multiscale Differentiable Physics‐Informed Machine Learning

Yalan Song, Tadd Bindas, Chaopeng Shen, Wouter Johannes Maria Knoben et autres

Abstract The National Water Model (NWM) is a key tool for flood forecasting, planning, and water management. Key challenges facing the NWM include calibration and parameter regionalization when confronted with big data. We present two novel versions of high‐resolution (∼37 km 2 …

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Enhanced isolation in aperture fed dielectric resonator MIMO antennas for 5G Sub 6 GHz applications

Arpita Patel, Trushit K. Upadhyaya, M. V. Swati, Om Prakash Kumar

Abstract A quad-port dielectric resonator antenna (DRA) is proposed for sub-6 GHz 5G MIMO applications, featuring high isolation, dual-band operation, and enhanced efficiency. The antenna is designed using electromagnetic coupling with a triangular patch to excite the square dielectric resonators (DRs) at …

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Evaluation of Worst-Case Power-Delay Performance for a 1-Bit Full Adder

Pallavi G. Darji, Devansh Makwana, Arpita Patel, Purvang D. Dalal et autres

The growing demand for high-performance computing requires the development of compact, high-speed, and energy-efficient processor architectures. As a critical component within Arithmetic Logic Units(ALUs) and Floating-Point Units (FPUs), the full adder significantly impacts overall system performance and power efficiency. This study investigates …

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DEVELOPMENT AND CHARACTERIZATION OF SL-325, A DR3-TARGETED, ANTAGONISTIC ANTIBODY FOR THE TREATMENT OF IBD

Mahmud M. Hussain, Anne Y. Lai, Derek A. Franklin, Noah Joseph Murr et autres