Shimei Qiu

Glutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1 mediated metabolic reprogramming

Jiatong Li, Ao Gu, Ziheng Jia, Mengyao Li et autres

Approximately 90% of patients with pancreatic cancer harbor KRAS mutations, predominantly the KRAS G12D subtype. HRS-4642, a non-covalent inhibitor targeting KRAS G12D , demonstrates potent antitumor efficacy but may ultimately lead to resistance. This study investigates the mechanisms underlying KRAS G12D inhibitor …

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Bile acid stress induces a nontranscriptional function of TFAP2A via stabilizing GOLIM4 to promote gallbladder cancer survival

Nannan Tang, Ao Gu, Jinlu Zuo, M Li et autres

Gallbladder cancer (GBC) is characterized by a bile acids (BAs)-rich microenvironment that imposes significant endoplasmic reticulum (ER) stress. While the transcription factor AP-2α (TFAP2A) is upregulated in GBC, its functional role in this specific stress context remains unknown. This study investigates how …

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Macrophage-rich niches regulate T cell dynamics at the liver invasive margin during gallbladder cancer progression

Maolan Li, Zhaonan Liu, Shenbing Shan, Ziyao Jia et autres

Liver invasion is one of the most frequent events in the progression of gallbladder cancer (GBC). However, the cellular and pathological role of the tumor-liver-interface microenvironment in liver invasion is still enigmatic. Here, we applied single-cell and spatial transcriptomics to systematically investigate …

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Full-length transcriptome atlas of gallbladder cancer reveals trastuzumab resistance conferred by ERBB2 alternative splicing

Ziyi Wang, Li Gao, Ziheng Jia, Liguo Liu et autres

Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein variants that facilitate cancer progression. Here, we employed the advanced long-read full-length transcriptome sequencing on gallbladder normal tissues, tumors, and cell lines to establish a comprehensive full-length gallbladder transcriptomic atlas. …

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Super‐Enhancer Reprograming Driven by SOX9 and TCF7L2 Represents Transcription‐Targeted Therapeutic Vulnerability for Treating Gallbladder Cancer

Siyuan Yan, Zhaonan Liu, Teng Wang, Yi Sui et autres

Gallbladder cancer (GBC) is a highly aggressive malignancy lacking clinically available targeted therapeutic agents. Super-enhancers (SEs) are crucial epigenetic cis-regulatory elements whose extensive reprogramming drives aberrant transcription in cancers. To study SE in GBC, the genomic distribution of H3K27ac is profiled in …

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Acylcarnitines promote gallbladder cancer metastasis through lncBCL2L11-THOC5-JNK axis

Yang Yang, Huaifeng Li, Ke Liu, Lu Zou et autres

Abstract Background The progression of gallbladder cancer (GBC) is accompanied by abnormal fatty acid β-oxidation (FAO) metabolism. Different types of lipids perform various biological functions. This study aimed to determine the role of acyl carnitines in the molecular mechanisms of GBC progression. …

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Deciphering the role of Enterococcus faecium cytidine deaminase in gemcitabine resistance of gallbladder cancer

Lin Jiang, Lingxiao Zhang, Yijun Shu, Yuhan Zhang et autres

Gemcitabine-based chemotherapy is a cornerstone of standard care for gallbladder cancer (GBC) treatment. Still, drug resistance remains a significant challenge, influenced by factors such as tumor-associated microbiota impacting drug concentrations within tumors. Enterococcus faecium, a member of tumor-associated microbiota, was notably enriched …

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Pancreatic cancer environment: from patient-derived models to single-cell omics

Ao Gu, Jiatong Li, Shimei Qiu, Shenglin Hao et autres

Pancreatic cancer (PC) is a highly malignant cancer characterized by poor prognosis, high heterogeneity, and intricate heterocellular systems. Selecting an appropriate experimental model for studying its progression and treatment is crucial. Patient-derived models provide a more accurate representation of tumor heterogeneity and …

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Fatty Acid Binding Protein 1 is an Independent Prognostic Biomarker for Gallbladder Cancer with Direct Hepatic Invasion

Shimei Qiu, Zhaonan Liu, Jun Hu, Ziyi Wang et autres

Background: Direct liver invasion (DI) is a predominant pathway of gallbladder cancer (GBC) metastasis, but the molecular alterations associated with DI remain addressed.This study identified specific genes correlated with DI, which may offer a potential biomarker for the diagnosis and prognosis of …

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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Guoqiang Li, Peng Pu, Mengqiao Pan, Xiaoling Weng et autres

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Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells

Zeyu Wang, Weijian Li, Xue Chao Wang, Qin Zhu et autres

BACKGROUND: Gallbladder cancer (GBC) is the most common malignant tumor of biliary tract. Isoliquiritigenin (ISL) is a natural compound with chalcone structure extracted from the roots of licorice and other plants. Relevant studies have shown that ISL has a strong anti-tumor ability …

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An efficient and convenient Fiber -2- based latex agglutination test for the detection of antibodies against fowl adenovirus serotype 4 in clinical samples

Shuzhen Chen, Qingdong Luan, Shimei Qiu, Yue Zhao et autres

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