Accès ouvert
2026
preprint
OpenAlex
Agustina Ayelen Sabater, Ana Paula Arévalo, Paula Perbolianachis, Pablo Sanchis et autres
Abstract The COVID-19 pandemic, together with previous outbreaks caused by highly pathogenic coronaviruses, highlighted the importance of understanding the host determinants that influence pathogenesis, both to improve our understanding of disease mechanisms, and to strengthen preparedness for future outbreaks. In our previous …
us, ar, uy
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Sarah R. Athans, Jiaojiao Zhou, Xiaozhuo Liu, Eduardo Cortes Gomez et autres
ABSTRACT Contrary to other cancer types, stromal antigen 2 (STAG2) expression is associated with shorter survival and an invasive phenotype in muscle invasive bladder cancer (MIBC). As a cohesin complex component, STAG2 regulates genome organization and cell type-specific transcription, yet its mechanistic …
us, ar
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Nicolás Anselmino, Pablo Sanchis, Juan Antonio Bizzotto, Estefanía Labanca et autres
Prostate cancer (PCa) is a biologically heterogeneous disease that frequently progresses to castration-resistant prostate cancer (CRPC), a challenging clinical stage. The underlying mechanisms driving CRPC progression and resistance to androgen receptor (AR) signaling inhibition (ARSI) remain incompletely understood. Emerging evidence implicates the …
us, es, ar
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Pablo Sanchis, Agustina Ayelen Sabater, Jiabin Dong, Peter D.A. Shepherd et autres
Abstract 6 UT MD Anderson Cancer Ctr., Houston, TX.Prostate cancer (PCa) progression remains a major clinical challenge with limited therapeutic options, and the complexity of metabolic pathways fueling advanced PCa rests poorly understood. We have identified a shift from glycolysis to ketone …
ar, us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Agustina Ayelen Sabater, Pablo Sanchis, Jun Yang, Jiabin Dong et autres
Abstract Prostate cancer (PCa) lethality is driven by treatment-refractory disease and skeletal metastases, yet progress in understanding these processes has been hindered by the lack of physiologically relevant models. To address this gap, we developed an integrated platform of MD Anderson PCa …
ar, us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Sabrina Ledesma-Bazan, Pablo Sanchis, Rocio A. Seniuk, Gastón Pascual et autres
Abstract Metastatic castration-resistant prostate cancer (mCRPC) represents the most advanced stage of the disease, with no curative treatments. lncRNAs are emerging regulators of prostate cancer (PCa) biology and the lncRNA PCGEM1 has been linked to tumorigenesis and c-Myc activity in AR positive …
ar
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
María Sol Ruiz, Ezequiel Jorge Sosa, Daniel Avendaño, Ignacio Gomez Mercado et autres
Introduction: Acute lymphoblastic leukemia is the most common childhood cancer, yet its diagnosis and risk classification remain incomplete in many regions due to limited access to molecular studies. Methods: We present the first comprehensive genetic and molecular characterization of childhood B-cell Acute …
ar
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
María Sol Ruiz, Lucila Viappiani, Daniel Avendaño, Ignacio Gomez Mercado et autres
Abstract Randomized trials in adult patients have shown that rituximab, a monoclonal antibody targeting CD20 (MS4A1 gene), can improve treatment response in de novo Acute Lymphoblastic Leukemia (ALL). These findings have led to clinical trials incorporating rituximab into first-line chemotherapy for pediatric …
ar
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Pablo Sanchis, Agustina Ayelen Sabater, Jimena Rada, Rocio A. Seniuk et autres
Prostate cancer (PCa) bone metastasis (BM) poses a significant clinical challenge due to the heterogeneity of treatment responses and patient outcomes. In this study, we examined the role of Protein Kinase A (PKA) signaling in modulating the expression of osteopontin (SPP1/OPN), a …
us, ar, es
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Sarah R. Athans, Nithya S. Krishnan, Swathi Ramakrishnan, Aimee B. Stablewski et autres
Abstract Stromal antigen 2 (STAG2) is associated with worse overall and progression free survival of muscle invasive bladder cancer (MIBC) patients. Furthermore, STAG2 expression is associated with motility and invasiveness of MIBC cell in vitro, suggesting that STAG2 acts as an oncogene …
us, ar
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Gastón Pascual, Pablo Sanchis, Agustina Ayelen Sabater, Rocio A. Seniuk et autres
Abstract Carbon monoxide (CO) is an endogenous gasotransmitter with proven anti-inflammatory, anti-apoptotic, and antiproliferative effects. CO-releasing molecules (CO-RMs) have been developed to deliver controlled doses of CO, differing in their CO-release kinetics and chemical structure, showing promise as therapeutic agents in various …
ar, us, fr
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Agustina Ayelen Sabater, Pablo Sanchis, Nicolás Anselmino, Juan Antonio Bizzotto et autres
Abstract Prostate cancer (PCa) lethality largely stems from the progression to castration-resistant PCa (CRPC) bone metastasis. We previously reported that fibroblast growth factor receptor 1 (FGFR1) is overexpressed in a subset of human CRPC bone metastases, and that FGFR1 overexpression of both …
ar, us
(code pays fourni par la source)