Ezequiel Jorge Sosa

Genetic characterization of pediatric B-cell acute lymphoblastic leukemia in Argentina uncovers molecular heterogeneity and novel variants

María Sol Ruiz, Ezequiel Jorge Sosa, Daniel Avendaño, Ignacio Gomez Mercado et autres

Introduction: Acute lymphoblastic leukemia is the most common childhood cancer, yet its diagnosis and risk classification remain incomplete in many regions due to limited access to molecular studies. Methods: We present the first comprehensive genetic and molecular characterization of childhood B-cell Acute …

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Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006–2015)

Florencia Andrea Castello, Ezequiel Jorge Sosa, Josefina Campos, Johana Monteserin et autres

BACKGROUND: Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis complex (Mtbc), remains a significant global health challenge, with Mtbc once again being the leading infectious killer worldwide. Despite over a century of research, the disease continues to pose a major threat, …

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Phylogenomic insights into LA-MRSA from Argentine pig farm environments: novel OptrA variant and regional emergence of an ST9 lineage co-circulating with international CC398 lineages

María José González, Julián Parada, Enrique Blasko, Ezequiel Jorge Sosa et autres

Introduction Staphylococcus aureus (SA) colonizes both humans and animals. The spread of livestock-associated methicillin-resistant S. aureus (LA-MRSA) in farms and the environment poses a public health concern. While CC398 is globally predominant, regional variation exists, and data from Argentina remain scarce. This …

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Genomic Characterization of XDR Mycobacterium tuberculosis Isolates in Argentina (2006-2015)

Florencia Andrea Castello, Ezequiel Jorge Sosa, Josefina Campos, Johana Monteserin et autres

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Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis

Federico A. Vignale, Andrea Hernandez Garcia, Carlos Pablo Modenutti, Ezequiel Jorge Sosa et autres

Yerba mate (YM, Ilex paraguariensis ) is an economically important crop marketed for the elaboration of mate, the third-most widely consumed caffeine-containing infusion worldwide. Here, we report the first genome assembly of this species, which has a total length of 1.06 Gb …

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Author response: Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis

Federico A. Vignale, Andrea Hernandez Garcia, Carlos Pablo Modenutti, Ezequiel Jorge Sosa et autres

DNA sequencing of the yerba mate (Ilex paraguariensis) genome reveals convergent genomic changes, biochemical pathways, mutations, and substrate-binding orientations responsible for caffeine biosynthesis when compared to coffee and tea plants.

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Molecular Characterization of Pediatric B-cell Acute Lymphoblastic Leukemia using Integrative Transcriptomics: A Multicenter Study in Argentina

María Sol Ruiz, Ezequiel Jorge Sosa, Daniel Avendaño, Ignacio Gomez Mercado et autres

Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer worldwide, and exhibits high molecular heterogeneity. Molecular subtypes are characterized by specific chromosomal and molecular alterations, which are critical for guiding risk-adapted therapies. However, the increasing number of recognized prognostic molecular …

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Breed variability in the cellular mediated immune response to experimental Neospora caninum infection in heifers

Franco Fiorani, Bibiana Elisabet Dallard, Ezequiel Jorge Sosa, Antonio Pardo et autres

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Nitrosative stress under microaerobic conditions triggers inositol metabolism in Pseudomonas extremaustralis

Esmeralda C. Solar Venero, Lucia Giambartolomei, Ezequiel Jorge Sosa, Darío Fernández Do Porto et autres

Bacteria are exposed to reactive oxygen and nitrogen species that provoke oxidative and nitrosative stress which can lead to macromolecule damage. Coping with stress conditions involves the adjustment of cellular responses, which helps to address metabolic challenges. In this study, we performed …

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High-throughput prioritization of target proteins for development of new antileishmanial compounds

Lucas Guimarães de Azevedo, Ezequiel Jorge Sosa, Artur T. L. Queiroz, Aldina Maria Prado Barral et autres

Leishmaniasis, a vector-borne disease, is caused by the infection of Leishmania spp., obligate intracellular protozoan parasites. Presently, human vaccines are unavailable, and the primary treatment relies heavily on systemic drugs, often presenting with suboptimal formulations and substantial toxicity, making new drugs a …

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Genome sequencing and analysis of black flounder (Paralichthys orbignyanus) reveals new insights into Pleuronectiformes genomic size and structure

Fernando D. Villarreal, Germán Burguener, Ezequiel Jorge Sosa, Nicolás Stocchi et autres

Black flounder (Paralichthys orbignyanus, Pleuronectiformes) is a commercially significant marine fish with promising aquaculture potential in Argentina. Despite extensive studies on Black flounder aquaculture, its limited genetic information available hampers the crucial role genetics plays in the development of this activity. In …

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Nitrosative stress under microaerobic conditions triggers inositol metabolism in Pseudomonas extremaustralis

Esmeralda C. Solar Venero, Lucia Giambartolomei, Ezequiel Jorge Sosa, Darío Fernández Do Porto et autres

Abstract Bacteria are exposed to reactive oxygen and nitrogen species that provoke oxidative and nitrosative stress which can lead to macromolecule damage. Coping with stress conditions involves the adjustment of cellular responses, which helps address metabolic challenges. In this study, we performed …

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