Accès ouvert
2026
article
OpenAlex
Rebecca Wegman, Michael Langberg, Haiteng Deng, Yuling Chen et autres
Protein arginine methylation has emerged as a key post-translational modification responsible for many facets of eukaryotic gene expression. To better understand the extent of this modification in cellular pathways, we carried out bioorthogonal methylation profiling in Saccharomyces cerevisiae to comprehensively identify the …
us, cn
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Sarah R. Athans, Jiaojiao Zhou, Xiaozhuo Liu, Eduardo Cortes Gomez et autres
ABSTRACT Contrary to other cancer types, stromal antigen 2 (STAG2) expression is associated with shorter survival and an invasive phenotype in muscle invasive bladder cancer (MIBC). As a cohesin complex component, STAG2 regulates genome organization and cell type-specific transcription, yet its mechanistic …
us, ar
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Accès ouvert
2026
preprint
OpenAlex
Kathryn E. Maraszek, Arwen A. Tisdale, Hunter D. Reavis, Xiaozhuo Liu et autres
Pancreatic ductal adenocarcinoma (PDAC) is an intractable disease with few effective treatment options. PDAC is characterized by a dense, fibro-inflammatory tumor microenvironment (TME) consisting mainly of cancer-associated fibroblasts (CAFs) and a CAF-generated collagen-rich extracellular matrix (ECM). As the ECM has profound impacts …
us, au
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Stuthi Perimbeti, Anmbreen Jamroze, Dharmesh Gopalakrishnan, Rohit Jain et autres
PURPOSE: Castration and enzalutamide induce BCL-2 to drive therapy resistance in prostate cancer (PCa). We conducted a phase Ib trial to test that metastatic castration-resistant PCa (mCRPC) can be effectively targeted by combining enzalutamide with the BCL-2 inhibitor venetoclax. EXPERIMENTAL DESIGN: This …
us, ae
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Kathryn E. Maraszek, Hunter D. Reavis, Arwen A. Tisdale, Xiaozhuo Liu et autres
Abstract Pancreatic cancer is a highly lethal malignancy with a 5-year survival rate of 13.3%. The disease is characterized by a dense, desmoplastic stroma comprised of extracellular matrix (ECM) proteins produced by cancer-associated fibroblasts (CAFs). This dense ECM has profound impacts on …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Anmbreen Jamroze, Xiaozhuo Liu, Wen Li, Han Yu et autres
ABSTRACT BCL-2 has been implicated in prostate cancer (PCa) progression and development of castration-resistant disease (CRPC). However, it remains unclear how the BCL-2- and AR-expressing PCa cell populations evolve across the PCa continuum, how AR molecularly regulates BCL-2 and whether BCL-2 represents …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Daric J. Wible, Wen Li, Xiaozhuo Liu, Manu Sebastian et autres
ABSTRACT Loss-of-function mutations in autophagy-related (ATG) genes are rare in cancer. However, we report herein that ATG5 is fully deleted in ∼14% of prostate cancers (PCa), rivaling that of well-established tumor suppressor genes. ATG5 expression was downregulated at both mRNA and protein …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Xiaozhuo Liu, Anmbreen Jamroze, Eduardo Cortes, Yibing Ji et autres
Abstract Background Cancer progression is often accompanied by dedifferentiation and acquisition of stem cell-like properties (stemness). In prostate cancer (PCa), lineage plasticity and therapy resistance remain major clinical challenges, yet a unified quantitative transcriptomic framework connecting stemness, androgen receptor (AR) signaling, castration …
us, au, cn
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Stuthi Perimbeti, Anmbreen Jamroze, Dharmesh Gopalakrishnan, Rohit Jain et autres
ABSTRACT Purpose Castration and enzalutamide induce BCL-2 to drive therapy resistance in prostate cancer (PCa). We conducted a phase Ib trial to test that metastatic castration-resistant PCa (mCRPC) can be effectively targeted by combining enzalutamide with the BCL-2 inhibitor venetoclax. Experimental Design …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xu Zhao, Xianhao Huo, Ran Zhao, Xiaozhuo Liu et autres
Objective: Our group aimed to explore the effect of different dosages of citicoline on ischemic stroke (IS) patients and determine the most appropriate dosage for these patients. Methods: The databases of PubMed, Cochrane Library, Medline, Web of Science, and Embase were searched …
cn
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Xianhao Huo, Xu Zhao, Xiaozhuo Liu, Yifan Zhang et autres
This study aimed to explore the effect of observation, microsurgery, and radiotherapy for patients with vestibular schwannoma (VS). We searched PubMed, Medline, Embase, Web of Science, and Cochrane library from their establishment to July 31, 2024. 34 non-RCTs and 1 RCT that …
cn
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Mei Li, Xianhao Huo, Qing Chang, Xiaozhuo Liu et autres
Objective: This network meta-analysis aims to explore the efficacy and safety of neuroprotective agents in patients with ischemic stroke and attempts to identify which drug is the most effective in improving outcomes for patients with acute ischemic stroke (AIS) through a ranking …
cn
(code pays fourni par la source)