Muhammad Nazmul Hasan

Nintedanib inhibits the VEGFR–ERK signaling pathway in human KRAS-mutated cancer cells

Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan, Toshinori Hyodo et autres

Abstract KRAS mutations are significant drivers in various cancers, and existing drug discovery attempts targeting these mutations have largely been unsuccessful, emphasizing the need for more effective therapies. In this study, the screening library, which contains 1,374 chemical compounds, identified nintedanib, a …

jp, bd, us (code pays fourni par la source)

Nintedanib inhibits the VEGFR–ERK signaling pathway in human KRAS-mutated cancer cells

Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan, Toshinori Hyodo et autres

Abstract KRAS mutations are significant drivers in various cancers, and existing drug discovery attempts targeting these mutations have largely been unsuccessful, emphasizing the need for more effective therapies. In this study, the screening library, which contains 1,374 chemical compounds, identified nintedanib, a …

jp, bd, us (code pays fourni par la source)

Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A-deficient pleural mesothelioma

Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan, Hideki Murakami et autres

Pleural mesothelioma (PM) is an uncommon yet deadly cancer linked to asbestos exposure. The lack of effective early diagnosis and treatment leads to reduced life expectancy among patients with PM. This study aims to identify a novel molecular target inhibitor to develop …

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Characterization of targeted knock-in achieved via tandem paired nicking mediated by CRISPR/Cas9 nickases

Md Towhid Ahmed Shihan, Toshinori Hyodo, Takeshi Fujino, Md Lutfur Rahman et autres

jp (code pays fourni par la source)

Anti-N Antibody Reacting at 37°C: An Unusual Reaction in Antibody Screening in a 20-Year-Old Male Liver Donor

Muhammad Nazmul Hasan

International audience

Anti-LW masquerading as anti-D in a D+ patient

Bushra Moiz, Muhammad Nazmul Hasan, Muhammad Umar Salman, Bhawna Kumari et autres

Abstract LW a , LW ab , LW b , and LWEM are the four main antigens of the Landsteiner–Weiner (LW) blood group system. LW expression may be weakened during pregnancy and immune dysregulation, with the subsequent appearance of anti-LW. Here, we …

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Correction: IgG antibodies to SARS-CoV-2 in asymptomatic blood donors at two time points in Karachi

Muhammad Nazmul Hasan, Bushra Moiz, Shama Qaiser, Kiran Iqbal Masood et autres

[This corrects the article DOI: 10.1371/journal.pone.0271259.].

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Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A -deficient malignant pleural mesothelioma

Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan, Hideki Murakami et autres

Abstract Malignant pleural mesothelioma (MPM) is an uncommon yet deadly cancer linked to asbestos exposure. The lack of effective early diagnosis and treatment leads to reduced life expectancy among patients with MPM. This study is aimed to identify a novel molecular target …

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ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells

Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu et autres

5' adenosine monophosphate-activated protein kinase-related kinase 5 (ARK5) is involved in mitochondrial ATP production and associated with poor prognosis of multiple myeloma (MM). However, the molecular mechanisms of ARK5 in MM remain largely unknown. This study examined the pathogenic role of ARK5 …

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Leucine zipper protein 1 ( LUZP1 ) regulates the constriction velocity of the contractile ring during cytokinesis

Toshinori Hyodo, Eri Asano‐Inami, Satoko Ito, Mai Sugiyama et autres

There has been a great deal of research on cell division and its mechanisms; however, its processes still have many unknowns. To find novel proteins that regulate cell division, we performed the screening using siRNAs and/or the expression plasmid of the target …

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Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene

Muhammad Nazmul Hasan, Toshinori Hyodo, Mrityunjoy Biswas, Md Lutfur Rahman et autres

CRISPR/Cas9 is a powerful genome editing system that has remarkably facilitated gene knockout and targeted knock-in. To accelerate the practical use of CRISPR/Cas9, however, it remains crucial to improve the efficiency, precision, and specificity of genome editing, particularly targeted knock-in, achieved with …

jp (code pays fourni par la source)

CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma

Sivasundaram Karnan, Akinobu Ota, Hideki Murakami, Md Lutfur Rahman et autres

Malignant mesothelioma (MMe) is a rare but aggressive malignancy. Although the molecular genetics of MMe is known, including BRCA1-associated protein-1 (BAP1) gene alterations, the prognosis of MMe patients remains poor. Here, we generated BAP1 knockout (BAP1-KO) human mesothelial cell clones to develop …

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