Nicole G. Campos

Adapting Sexual Behavior Survey Data to Parameterize an Agent-Based Model of Human Papillomavirus (HPV) Transmission

Jennifer C. Spencer, Emily A. Burger, Allison Portnoy, Nicole G. Campos et autres

PurposeSexual transmission of human papillomavirus (HPV) infection is important for capturing the indirect effects of interventions in mathematical models, but limited data create challenges for reflecting sexual behavior patterns over the lifespan of individuals and across heterogenous populations. We used nationally representative …

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Benefits beyond measure: herd effects of HPV vaccines

Nicolas Wentzensen, Nicole G. Campos

In the Lancet Public Health, Eva Meglic and colleagues1 report estimates of the herd effects of human papillomavirus (HPV) vaccination on incidence of cervical precancer based on population registry data from the Swedish HPV vaccination and cervical cancer screening programmes.

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Supplementary Tables S1-S11 and Figure S1 from Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047

Meredith S. Shiels, Stanley Lipkowitz, Nicole G. Campos, MARK H. SCHIFFMAN et autres

Supplemental Table 1. 15 leading causes of cancer death in the U.S. in 2019. Supplemental table 2. Trends in total cancer mortality rates, incidence rates and relative survival in the U.S. Supplemental table 3. Trends in lung cancer mortality rates, incidence rates …

Comparison of CO2-based cryotherapy, non-gas-based cryotherapy, and thermal ablation for cervical intraepithelial neoplasia grade 2 and 3: a randomised, controlled, phase 3 non-inferiority trial

Miriam Cremer, Karla Alfaro, Montserrat Soler, RACHEL J. MASCH et autres

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IPVS Consensus Statement on The Natural History of Cervical Human Papillomavirus Infection

Marc D. Ryser, Ignacio G. Bravo, Nicole G. Campos, Anne Hammer et autres

BACKGROUND: Changes in cervical type-specific human papillomavirus (HPV) detection may reflect both natural variation in detectability and recent infection or clearance. METHODS: The Policy Committee of the International Papillomavirus Society (IPVS) convened a multidisciplinary working group to review scientific evidence and terminology …

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Más allá de la sonrisa. Diagnóstico temprano del síndrome de Williams-Beuren

Diana Caterine Navarrete Delgado, Nicole G. Campos, Carmen Luz Marrero Pérez, Lorenzo Martín Fumero

El Síndrome de Williams-Beuren (WBS) es un trastorno genético multisistémico causado por la deleción de 1.5-1.8 Mb en la región 7q11.23, cuya incidencia es de aproximadamente 1 en 7.500 nacidos vivos y que se caracteriza por una combinación de anomalías craneofaciales, cardiovasculares, …

Estimated Cancer Risk in Females Who Meet the Criteria to Exit Cervical Cancer Screening

Shalini Kulasingam, Inge M.C.M. de Kok, Abhinav Mehta, Erik E. L. Jansen et autres

Importance: Cervical screening guidelines in the US recommend that most females can exit routine screening at age 65 years following 2 recent consecutive negative cotest results (concurrent human papillomavirus and cytology tests). However, empirical data on the subsequent risks of cancer and …

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Initial evaluation of a new cervical screening strategy combining human papillomavirus genotyping and automated visual evaluation: the Human Papillomavirus–Automated Visual Evaluation Consortium

Brian Befano, Jayashree Kalpathy–Cramer, Didem Egemen, Federica Inturrisi et autres

The HPV-Automated Visual Evaluation Consortium is validating a cervical screening strategy enabling accurate cervical screening in resource-limited settings. A rapid, low-cost human papillomavirus (HPV) assay permits sensitive HPV testing of self-collected vaginal specimens; HPV-negative women are reassured. Triage of positive participants combines …

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Generalizable deep neural networks for image quality classification of cervical images

Syed Rakin Ahmed, Brian Befano, Didem Egemen, Ana Cecilia Rodríguez et autres

Successful translation of artificial intelligence (AI) models into clinical practice, across clinical domains, is frequently hindered by the lack of image quality control. Diagnostic models are often trained on images with no denotation of image quality in the training data; this, in …

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Impact of screening for human papillomavirus-positive oropharyngeal cancers: a microsimulation-based modeling study

Rebecca Landy, Barry I. Graubard, Carole Fakhry, Nicole G. Campos et autres

BACKGROUND: We estimated the impact of screening on morbidity and mortality of human papillomavirus (HPV)16-positive oropharyngeal cancer among US men aged 45-79 years. METHODS: We developed an individual-level, state-transition natural history microsimulation model to estimate the impact of screening using oral HPV16 …

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A cervical cancer control strategy for lower-resource settings: interventions to complement one-dose HPV vaccination

Nicole G. Campos, Douglas R. Lowy, Silvia de Sanjosé, Mark Schiffman

One-dose prophylactic HPV vaccination of pre-adolescents may reduce cervical cancer deaths dramatically in lower-resource settings, but the benefits of achieving immediate high coverage among pre-adolescents would not be realized for 20 to 40 years. Prophylactic vaccine efficacy is reduced after sexual debut, …

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Meeting report: Considerations for trial design and endpoints in licensing therapeutic HPV16/18 vaccines to prevent cervical cancer

Peter M Dull, Sharon L. Achilles, Rafi Ahmed, Ruanne V. Barnabas et autres

• Effective HPV therapeutic vaccines could reduce HPV-related cancer and associated deaths. • An expert convening was held in September 2023 to provide guidance on vaccine trial design. • Study design for vaccines targeting cervical precancers has regulatory precedent. • Licensure pathways …

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