Douglas R. Lowy

Role of endothelial Dlc1 in embryonic vascular development and adult bone marrow hematopoiesis

Jingxin Feng, Marian E. Durkin, Meiting Yang, Lili Li et autres

Bone marrow endothelial cells (ECs) form specialized vascular niches that support hematopoietic stem and progenitor cells (HSPC), yet the molecular regulators of this function remain incompletely defined. Here, we identify the Rho GTPase-activating protein Dlc1 as an essential regulator of developmental vasculogenesis, …

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Cancer-attributable costs in older adults: SEER-Medicare analysis of variation by site, stage, and race

Angela B. Mariotto, Lindsey Enewold, Christopher A. Zeruto, Yoon Duk Hong et autres

BACKGROUND: Advances in cancer treatment and increased survivorship have altered the economic burden of cancer care. Updated patient-level estimates of cancer-attributable costs, based on clinical and socioeconomic factors, are required. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data, we …

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Exceeding expectations: factors contributing to the potency of human papillomavirus vaccines

John T. Schiller, Rhonda C. Kines, Patricia M. Day, Nicolas Çuburu et autres

The commercial prophylactic vaccines for human papillomavirus (HPV) are subunit vaccines composed of spontaneously assembled virus-like particles formed from 360 copies of the L1 major virion protein. The vaccines have exceeded expectations in immunogenicity, clinical trials efficacy, and effectiveness in national immunisation …

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Abstract 4473: Advancing new rational drug combinations to treat mutant KRAS-driven pancreatic adenocarcinoma.

Brajendra K. Tripathi, Sophia M. Shahin, Elise Van Meter, Marian E. Durkin et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis, largely due to late diagnosis and limited response to currently available therapies. Identifying effective drug combinations that harness PDAC-specific vulnerabilities remains a major challenge for molecularly targeted therapy. …

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The Biomarkers Consortium: 20 years of advancing precision medicine

Amanda Klein, Jeffrey Siegel, S. Hoffmann, Jennifer D. Hamilton et autres

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Development of HPV 35 serology assays for assessment of immune responses to HPV 35 after infection and vaccination

Kathleen Kim, Carolina Porras, Aimee R. Kreimer, Heidi Hempel et autres

Human papillomavirus (HPV) 16 and HPV 18 are the two most common HPV types leading to cervical cancer; however, HPV 35 accounts for about 2% of invasive cervical cancers worldwide and a higher percentage in women of African ancestry. Further investigation into …

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Development of HPV 35 serology assays for assessment of immune responses to HPV 35 after infection and vaccination

Kathleen Kim, Carolina Porras, Aimee R. Kreimer, Heidi Hempel et autres

Human papillomavirus (HPV) 16 and HPV 18 are the two most common HPV types leading to cervical cancer; however, HPV 35 accounts for about 2% of invasive cervical cancers worldwide and a higher percentage in women of African ancestry. Further investigation into …

Development of HPV 35 serology assays for assessment of immune responses to HPV 35 after infection and vaccination

Kathleen Kim, Carolina Porras, Aimee R. Kreimer, Heidi Hempel et autres

Human papillomavirus (HPV) 16 and HPV 18 are the two most common HPV types leading to cervical cancer; however, HPV 35 accounts for about 2% of invasive cervical cancers worldwide and a higher percentage in women of African ancestry. Further investigation into …

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Ulrik Ringborg, Joachim von Braun, Julio E. Celis, Anton Berns et autres

The cancer problem is expanding, particularly in low- and middle-income countries (LMICs). Preventive measures can reduce the incidence by 40-50%, and cure rates have increased during the past decades in a number of cancers. However, optimizing prevention programmes and increasing cure rates …

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Noninferiority of One HPV Vaccine Dose to Two Doses

Aimée R. Kreimer, Carolina Porras, Danping Liu, Allan Hildesheim et autres

BACKGROUND: Multidose human papillomavirus (HPV) vaccination is efficacious, yet the vaccine has been underused globally. Emerging data suggest that a single dose may provide protection. Whether a single dose of HPV vaccine would provide similar protection to two doses is uncertain. METHODS: …

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Post-attachment neutralization of HPV16 by antibodies derived from Gardasil-vaccinated women

Patricia M. Day, Cynthia D. Thompson, Erin M. Scherer, J J Carter et autres

HPV vaccines exhibit high type-specific and antibody-mediated protection against anogenital infection, even after a single dose. Complete and long-term "sterilizing" immunity against incident infection appears to be established in most HPV vaccinees, suggesting that not only are persistent levels of virus-inhibiting antibodies …

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The impact of focused federal initiatives on pediatric cancer research

Subhashini Jagu, Malcolm A. Smith, Nita L. Seibel, Emily S. Tonorezos et autres

Federal initiatives, including the Childhood Cancer Data Initiative and the Childhood Cancer Survivorship, Treatment, Access, and Research Act, are advancing pediatric cancer data sharing and strengthening infrastructure required for clinical trials, biobanking, and biospecimen collection. These efforts aim to transform pediatric cancer …

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