Peter Santa Maria

Targeting the FtsH protease unmasks a universal vulnerability to antimicrobial peptoids

Zin Mie Mie Tun, Kristian Sørensen, Ella Moore, J Chen et autres

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Adenosine Triphosphate-Coated Gold Nanoclusters as Evolutionary Adjuvants Suppress fusA -Mediated Antibiotic Resistance Evolution

Zin Mie Mie Tun, Daria Van Tyne, Laurent Adonis Bekale, Peter Santa Maria

gene are crucial pathways for high-level aminoglycoside resistance, creating a major barrier to treating chronic cystic fibrosis (CF) lung infections. While lab models often failed to replicate the translational gap seen in advanced clinical strains, we found that metabolic dormancy, rather than …

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A novel autoinflation device for persistent pediatric otitis media with effusion: A prospective single-arm cohort study

Nanki Hura, Maria‐Jose Soto, Zarna Lalwani, Intan Oldakowska et autres

BACKGROUND: Autoinflation is a non-surgical option for pediatric otitis media with effusion (OME), but existing devices are limited to children ≥4 years and lack objective adherence confirmation. EarFlo® is a novel prototype autoinflation device designed for younger children with built-in objective treatment …

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Chronic Ear Disease and Cholesteatoma

Michael B. Gluth, Peter Santa Maria

Abstract This section characterizes a broad array of inflammatory pathologies of the middle ear and mastoid known as “chronic ear disease.” Theories as to the mechanisms of disease, as well as how emerging research can guide treatment, are outlined in depth.

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Advances in immune mediated inner ear disease

Peter Kullar, Peter Santa Maria

Immune-mediated inner ear disease (IMIED) is emerging in our understanding as a cause of sensorineural hearing loss (SNHL). It poses a considerable diagnostic challenge due to the lack of specific tests and diagnostic biomarkers as well as clinical features that overlap with …

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Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs

Tian Wang, Angela H. Ling, Sara E. Billings, Davood Karimi Hosseini et autres

Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate in vivo remains unknown. Here we procured …

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SPARKing academic technologies across the valley of death

Jeewon Kim, Stephen Kargotich, Sophia H. Lee, Rieko Yajima et autres

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New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2022

Franklin M. Wu, Daniel Gorelik, Michael Joel Brenner, Masayoshi Takashima et autres

Objective: To review new drugs and devices relevant to otolaryngology approved by the Food and Drug Administration (FDA) in 2022. Data Sources: Publicly available FDA data on drugs and devices approved in 2022. Review Methods: A preliminary screen was conducted to identify …

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214 Impact of Cochlear Dose on Hearing Preservation Following Stereotactic Radiosurgery in Treatment of Vestibular Schwannomas: A Multi-Center Study

Andrea L. Klein, Steven D. Chang, Alexander Muacevic, Jonathan H. Sherman et autres

INTRODUCTION: Stereotactic radiosurgery (SRS) is a well-established treatment option for patients with vestibular schwannomas (VS). Hearing loss remains one of the main morbidities of VS and its treatments, including SRS. Effects of radiation parameters of SRS on hearing remains largely unknown. METHODS: …

Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ears

Tian Wang, Angela H. Ling, Sara E. Billings, Davood Karimi Hosseini et autres

Abstract Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate remains unknown. Here we procured live, …

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The Role of Neutrophils in Pseudomonas aeruginosa Chronic Suppurative Otitis Media

Kelly M. Khomtchouk, Ali Kouhi, Peter Santa Maria

Abstract Chronic suppurative otitis media is largely due to biofilm-forming bacteria, of which a common pathogen is Pseudomonas aeruginosa. Neutrophils are well-known to have various contributions in both promoting and restricting bacterial growth in other biofilm-mediated diseases, as they are one of …

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Long-Term Hearing Outcomes following Stereotactic Radiosurgery in Patients with Vestibular Schwannomas

Peter Santa Maria, Yangyang Shi, Richard Klaus Gurgel, Carleton Eduardo Corrales et autres

Objective To determine the long-term hearing results following stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) according to pretreatment hearing level and various tumor factors. To explain why the widely used Gardner-Robinson (G-R) method of reporting VS hearing outcomes in the radiation oncology …

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