Accès ouvert
2026
article
OpenAlex
Margot Hadjadj, Malihe Hassanzadeh, Justin Martel, Marie-Frédérique Roy et autres
The angiotensin II (AngII) type 1 receptor (AT1R) is a key prototypical G protein-coupled receptor in cardiovascular regulation. Biased agonists activating G protein or β-arrestin pathways offer therapeutic promise, but the molecular determinants of this signaling bias and its physiological implications remain …
ca, fr
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Jacob L. Léger, Nawal Amhis, Sarah Mansouri, Maxime Léveillé et autres
Abstract The immunosuppressive tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is a major factor that limits the therapeutic effect of immunotherapy and chemotherapy in PDAC patients. A promising approach is the use of oncolytic viruses (OVs), particularly the vesicular stomatitis virus …
ca
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Haoran Geng, Brian J. Holleran, Andréanne Laniel, Erwan Lanchec et autres
Abstract The K53N mutation in Gαs has been identified in patients with Albright’s Hereditary Osteodystrophy (AHO), pseudohypoparathyroidism type 1A (PHP1a), and dilated cardiomyopathy; however, its molecular mechanism remains unclear. Here, we characterize the molecular, cellular, and physiological consequences of the K53N mutation …
ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Kevin Neil, Samuel Génier, Julie Douchin, Hugo Giguère et autres
BACKGROUND: Checkpoint inhibitors revolutionized cancer treatment by potentiating antitumor immune responses. However, many patients do not respond to these therapies, often due to the lack of a pre-existing immune response against cancer cells. Developing immunotherapies that promote cancer-cell antigen recognition, and the …
ca
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Margot Hadjadj, Malihe Hassanzadeh, Hugo Giguère, Alexandre Murza et autres
ABSTRACT The angiotensin II (AngII) type 1 receptor (AT1R) is a key prototypical G protein-coupled receptor in cardiovascular regulation. Biased agonists that activate G protein or β-arrestin pathways provide promising therapeutic potential, but the molecular determinants for this signaling bias and its …
ca, fr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jonathan Berthiaume, Audrey‐Ann Dumont, L Dumont, Hugo Giguère et autres
Cardiomyocyte hypertrophy is regulated by several factors, including the ADP-ribosylation factor (Arf) family of small G proteins, among others. For instance, ArfGAP with dual pleckstrin homology domains 1 (Adap1) exerts an anti-hypertrophic effect in cultured cardiomyocytes. Its homologous protein, Adap2, is also …
ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Lauren Daniel, Hugo Giguère, Léa J Custeau, Jacob L. Léger et autres
Non-muscle-invasive bladder cancer (NMIBC) can progress to muscle-invasive disease, with transurethral resection followed by Bacillus Calmette-Guérin (BCG) immunotherapy reducing this risk. Effective immunotherapies for BCG-resistant NMIBC are lacking. This study directly compares the efficacy of the oncolytic vesicular stomatitis virus (VSVd51) encoding …
ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Guillaume St-Cyr, Lauren Daniel, Hugo Giguère, Rayanna Birtch et autres
Triple-negative breast cancer (TNBC) metastasis is driven, in part, by the epithelial-to-mesenchymal transition (EMT), a process critical for cancer cell migration and invasion. Current treatment options, including immunotherapies and targeted therapies, demonstrate limited efficacy in this aggressive disease, underscoring the need for …
ca
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Kevin Neil, Samuel Génier, Hugo Giguère, Lauren Daniel et autres
Checkpoint inhibitors revolutionized cancer treatment by potentiating antitumor immune responses. However, many patients do not respond to these therapies, often due to a lack of pre-existing immune response against cancer cells. Personalized cancer vaccines promote cancer cell antigen recognition and mount antitumor …
ca
(code pays fourni par la source)
2024
article
OpenAlex
Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier et autres
Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here, we showed that defects in the endothelial cell (EC) compartment of the vascular stem cell niche in mouse models of Duchenne …
ca, ch
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Seyedeh-Raheleh Niavarani, Guillaume St-Cyr, Lauren Daniel, Christine K. Lawson et autres
Introduction: Triple negative breast cancer (TNBC) is the most aggressive and hard-to-treat subtype of breast cancer, affecting 10-20% of all women diagnosed with breast cancer. Surgery, chemotherapy and hormone/Her2 targeted therapies are the cornerstones of treatment for breast cancer, but women with …
ca, sa
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Catherine Lapointe, Laurence Vincent, Hugo Giguère, Mannix Auger‐Messier et autres
Background Deep vein thrombosis (DVT) is the primary cause of pulmonary embolism and the third most life‐threatening cardiovascular disease in North America. Post‐DVT anticoagulants, such as warfarin, heparin, and direct oral anticoagulants, reduce the incidence of subsequent venous thrombi. However, all currently …
ca, jp, se, de
(code pays fourni par la source)