Rita Raisman‐Vozari

Impact of chronic doxycycline treatment in a mouse model of tauopathy

Ramiro Clerici-Delville, Javier Muñiz, Indiana Páez-Paz, Carolina Lucía Facal et autres

Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy), a tetracycline antibiotic commonly used to treat bacterial infections and skin conditions, has also shown some anti-inflammatory and …

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The Small Molecule DDOX Confers Neuroprotection and Alleviates Motor Deficits in a Preclinical Rat Model of Parkinson’s Disease

Glauce Crivelaro Nascimento, Laurent Ferrié, Rita Raisman‐Vozari, Bruno Figadère et autres

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DDOX expands the repertoire of tetracyclines for Parkinson’s disease by preventing the cellular uptake and intracellular impact of α-synuclein preformed fibrils

María del Milagro Terán, Rodrigo Hernán Tomas‐Grau, Estefanía Silvana Soliz-Santander, María Laura Guayán et autres

The increasing prevalence of Parkinson's disease (PD) requires innovative multi-targeted disease-modifying therapies to counteract the toxicity associated with the amplification, propagation, and accumulation of alpha-synuclein (α-Syn) aggregates in the brain. Tetracyclines, particularly doxycycline, have demonstrated multimodal neuroprotective effects, both in vitro and …

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Protein Coaggregation in Caribbean Atypical Parkinsonism: The Contribution of Annonacin

Florencia González‐Lizárraga, Susana Boluda, José Ruiz Hidalgo, César L. Ávila et autres

AIMS: There is an unexpectedly high proportion of atypical forms of degenerative parkinsonism in the French Caribbean islands. Residents of these islands are thought to be susceptible to Caribbean atypical parkinsonism (CAP) owing to their consumption of Annonaceae plant products containing the …

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Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative

Bianca Andretto de Mattos, Rodrigo Hernán Tomas‐Grau, T. Fernandes, Florencia González‐Lizárraga et autres

We aimed to simulate tau abnormalities-specifically hyperphosphorylation and aggregation-that are hallmarks of tauopathies, including Alzheimer's disease, to evaluate tau-targeting therapies. To model pathological p-tau accumulation at early disease stages, we exposed mouse cortical cultures to redox-active iron from hemin (Hm), a breakdown …

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Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage

Aurore Tourville, Ismaïla Ciss, Rafaela Ribeiro Silva, Bianca Andretto de Mattos et autres

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Anti-nociceptive effects of non-antibiotic derivatives of demeclocycline and doxycycline against formalin-induced pain stimulation

Glauce Crivelaro Nascimento, Airam Nicole Vivanco-Estela, Laurent Ferrié, Bruno Figadère et autres

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Front Cover: C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration (ChemMedChem 12/2024)

Clémence Rose, Rodrigo Hernán Tomas‐Grau, Brenda Zabala, Patrick P. Michel et autres

The Front Cover picture shows α-synuclein fibrils desaggregated by our two most promising tetracycline derivatives. The background is a labyrinth-like pattern reminiscent of brain tissue. More details can be found in in the Research Article by Rita Raisman-Vozari, Laurent Ferrié, Bruno Figadère, …

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Contribution of the Mitochondrial Complex I Inhibitor Annonacin to the Alpha-synuclein/Tau Co-pathology in Caribbean Atypical Parkinsonism (P2-3.010)

Florencia González‐Lizárraga, Susana Boluda, José Ruis Hidalgo, César L. Ávila et autres

To further characterize protein amyloid aggregation atypical degenerative parkinsonism in the French Caribbean islands, and to determine to what extent annonacin could contribute to this pathogenic process.

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4′-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms

Maurício dos Santos Pereira, Gabriel H Dias de Abreu, Leonardo Calaça Arruda Vanderlei, Rita Raisman‐Vozari et autres

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C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration

Clémence Rose, Rodrigo Hernán Tomas‐Grau, Brenda Zabala, Patrick P. Michel et autres

Abstract Doxycycline, a semi‐synthetic tetracycline, is a widely used antibiotic for treating mild‐to‐moderate infections, including skin problems. However, its anti‐inflammatory and antioxidant properties, combined with its ability to interfere with α‐synuclein aggregation, make it an attractive candidate for repositioning in Parkinson's disease. …

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The two synthetic cannabinoid compounds 4′‐ F‐CBD and HU ‐910 efficiently restrain inflammatory responses of brain microglia and astrocytes

Maurício dos Santos Pereira, Bruna M. Santos, Rocio Giménez, Francisco Silveira Guimarães et autres

To study the anti-inflammatory potential of the two synthetic cannabinoids 4'-F-CBD and HU-910, we used post-natal brain cultures of mouse microglial cells and astrocytes activated by reference inflammogens. We found that 4'-F-CBD and HU-910 efficiently curtailed the release of TNF-α, IL-6, and …

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