2024
paratext
OpenAlex
Clémence Rose, Rodrigo Hernán Tomas‐Grau, Brenda Zabala, Patrick P. Michel et autres
The Front Cover picture shows α-synuclein fibrils desaggregated by our two most promising tetracycline derivatives. The background is a labyrinth-like pattern reminiscent of brain tissue. More details can be found in in the Research Article by Rita Raisman-Vozari, Laurent Ferrié, Bruno Figadère, …
fr, ar
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Clémence Rose, Rodrigo Hernán Tomas‐Grau, Brenda Zabala, Jean Michel Brunel et autres
Doxycycline, a semi-synthetic tetracycline, is a widely used antibiotic for mild-to-moderate infections. However, its pleiotropic effects, such as anti-inflammatory and antioxidant properties, combined with its ability to interfere with α-synuclein inhibiting its aggregation, make it an attractive candidate for repositioning in Parkinson's …
fr, ar
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Clémence Rose, Laurent Ferrié, Rodrigo Hernán Tomas‐Grau, Brenda Zabala et autres
Doxycycline is a tetracycline commonly used for its antibiotic properties and capacity to treat acne- and rosacea-like skin lesions. It has also recently demonstrated interesting effects against Parkinson's disease pathomechanisms. Notably, doxycycline was reported to limit amyloid-type aggregation of α-synuclein and curtail …
fr, ar
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Rodrigo Hernán Tomas‐Grau, Florencia González‐Lizárraga, Diego Ploper, César L. Ávila et autres
The antibiotic tetracycline demeclocycline (DMC) was recently reported to rescue α-synuclein (α-Syn) fibril-induced pathology. However, the antimicrobial activity of DMC precludes its potential use in long-term neuroprotective treatments. Here, we synthesized a doubly reduced DMC (DDMC) derivative with residual antibiotic activity and …
ar, es, fr, us
(code pays fourni par la source)