Accès ouvert
2026
article
OpenAlex
Shannon B. Lavigne, Gabrielle A. Hromas, Ashley LaRoche, Alicia S. Parker et autres
Abstract INTRODUCTION Although Hispanic/Latine populations experience higher dementia rates, they remain underrepresented in frontotemporal dementia (FTD) research. This study examines clinical manifestations of FTD within a South Texas Hispanic/Latine cohort compared to national data. METHODS Participants diagnosed with FTD were included from …
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Accès ouvert
2025
article
OpenAlex
A. Campbell Sullivan, Gabrielle Zuniga, Paulino Ramirez, Roman A. Fernandez et autres
BACKGROUND: Approximately 40% of the human genome is composed of retrotransposons, virus-like sequences that are typically silenced at the transcriptional and post-transcriptional levels. We have previously discovered that retrotransposons are activated in a variety of human neurodegenerative disorders, including Alzheimer's disease and …
us
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2025
article
OpenAlex
A. Campbell Sullivan, Rima Chaudhari, Arash Salardini, Kevin F. Bieniek et autres
To describe a novel radiographic sign found in Lewy body dementia, which can be used to aid in diagnosis.
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Accès ouvert
2025
article
OpenAlex
Anna Campbell Sullivan, Gabrielle Zuniga, Paulino Ramirez, Roman A. Fernandez et autres
Abstract Retrotransposons constitute over 40% of the human genome. Studies in Drosophila , mice, cultured cells, and human brain show that retrotransposons are activated in tauopathies, including Alzheimer’s disease, and causally drive neurodegeneration. The reverse transcriptase inhibitor 3TC (lamivudine) reduces retrotransposon activation …
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Accès ouvert
2024
article
OpenAlex
Satomi Hiya, Carolina Maldonado‐Díaz, Susan Karijn Rohde, Mitzi M. Gonzales et autres
Although Alzheimer disease neuropathologic change (ADNC) is the most common pathology underlying clinical dementia, the presence of multiple comorbid neuropathologies is increasingly being recognized as a major contributor to the worldwide dementia burden. We analyzed 1051 subjects with specific combinations of isolated …
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Accès ouvert
2024
article
OpenAlex
Jennifer G Del Bosque, Chen‐Pin Wang, Roman A. Fernandez, Jeremy A. Tanner et autres
BACKGROUND: Hispanic adults comprise 19% of the US population, yet <8% of Alzheimer's Disease and Related Dementia (ADRD) research cohorts. Hispanic adults in the US are 1.5 times more likely to develop ADRDs compared to Non-Hispanics. Considering the projected growth in Hispanics …
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Accès ouvert
2024
article
OpenAlex
Júlia Teixeira de Castro, Sandra Azareli García Velázquez, Tiffany F. Kautz, Crystal Mendoza et autres
BACKGROUND: APP duplications are a rare form of familial Alzheimer's disease (AD). Research has shown variability in clinical presentation with full duplications. There is limited information on those with partial duplications, especially in underrepresented minorities. METHODS: A 64 y/o Hispanic male presented …
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Accès ouvert
2024
article
OpenAlex
Jeremy A. Tanner, Crystal Wiedner, Hugo Javier Aparicio, Mitzi M. Gonzales et autres
Abstract Background Plasma p‐tau biomarkers are promising diagnostic tools for widespread clinical use. However, recent studies have raised concerns regarding the effect of common medical comorbidities, such as cardiovascular disease (CVD), on plasma p‐tau specificity. These influences must be better understood to …
us, ie
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Accès ouvert
2024
article
OpenAlex
Amaya M Seidl, Marco I Boisselier, Ashley LaRoche, Chen‐Pin Wang et autres
Abstract Background The Apolipoprotein E (APOE) ε4 variant is the strongest genetic risk factor for Alzheimer’s disease (AD) and has been thoroughly studied in non‐Hispanic whites (NHW). However, its association with AD among Hispanic individuals is unclear, with existing studies yielding mixed …
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Accès ouvert
2024
article
OpenAlex
Carolina Maldonado‐Díaz, Satomi Hiya, Raquel Teixeira Yokoda, Kurt W. Farrell et autres
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), and cerebrovascular disease (CVD) frequently coexist, but little is known about the exact contribution of each pathology to cognitive decline and dementia …
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Accès ouvert
2024
preprint
OpenAlex
Anna Campbell Sullivan, Gabrielle Zuniga, Paulino Ramirez, Roman A. Fernandez et autres
ABSTRACT Retrotransposons are viral-like DNA sequences that constitute approximately 41% of the human genome. Studies in Drosophila, mice, cultured cells, and human brain indicate that retrotransposons are activated in settings of tauopathy, including Alzheimer’s disease, and causally drive neurodegeneration. The anti-retroviral medication …
us
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Accès ouvert
2023
article
OpenAlex
Aishwarya N. Patel, Ashley LaRoche, Vanessa M. Young, Ney Alliey‐Rodriguez et autres
Abstract Background The prevalence of Alzheimer’s disease and related dementias (ADRD) in the United States was estimated as 6.5 million people in 2022, with a five‐fold increase for the Hispanic/Latinx population expected by 2060. The South Texas Alzheimer’s Disease Center (STAC) was …
us
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