Accès ouvert
2026
article
OpenAlex
Shannon B. Lavigne, Gabrielle Hromas, Ashley LaRoche, Alicia S. Parker et autres
Abstract INTRODUCTION Although Hispanic/Latine populations experience higher dementia rates, they remain underrepresented in frontotemporal dementia (FTD) research. This study examines clinical manifestations of FTD within a South Texas Hispanic/Latine cohort compared to national data. METHODS Participants diagnosed with FTD were included from …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Janette Vazquez, Ashley LaRoche, Daniel MacCarthy, Roman Fernandez et autres
BACKGROUND: Generalizing dementia research findings from clinical studies to broader populations is challenging due to selective participation. This study evaluated associations between cardiovascular risk factors and cognitive function in the South Texas Alzheimer's Disease Research Center cohort (STAC), leveraging 2023 Behavioral Risk …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jeremy A. Tanner, Roslyn Valdespino, Tiffany F. Kautz, Godfrey Masette et autres
Abstract Background Sub‐Saharan Africa (sSA) is projected to have the fastest population growth in older adults globally, a >250% increase in Alzheimer's Disease (AD), and rapid growth in older people living with HIV (PLWH) well‐treated on antiretroviral therapies (ARTs) in the coming …
us, Ouganda, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Roslyn Valdespino, Gabrielle Hromas, Chen‐Pin Wang, Robert Paul et autres
BACKGROUND: Sub-Saharan Africa (SSA) faces accelerated growth of older adults, older people living with HIV (PLWH), and Alzheimer's Disease (AD). However, there is a shortage of human resources and contextually relevant diagnostic tools to assess cognitive impairment (CI) in the region. The …
us, Ouganda, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
A. Campbell Sullivan, Gabrielle Zuniga, Paulino Ramirez, Roman Fernandez et autres
BACKGROUND: Approximately 40% of the human genome is composed of retrotransposons, virus-like sequences that are typically silenced at the transcriptional and post-transcriptional levels. We have previously discovered that retrotransposons are activated in a variety of human neurodegenerative disorders, including Alzheimer's disease and …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sarah Horn, Chen‐Pin Wang, Pablo Coss, Okeanis Vaou et autres
BACKGROUND: Both quetiapine and pimavanserin are commonly used in clinical practice for psychosis (hallucinations and/or delusions) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB) - collectively referred to as Lewy body disease (LBD). Clinical trials to establish efficacy have been …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Gabrielle Hromas, Stephanie Santiago-Mejías, Chen‐Pin Wang, Roman Fernandez et autres
BACKGROUND: Determining the language of neuropsychological assessment in a bilingual patient population is difficult with implications for test performance and clinical interpretation. We compared two methods of identifying language dominance for neuropsychological testing in a sample of bilingual (English/Spanish) Hispanic/Latine patients in …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jeremy A. Tanner, Roslyn Valdespino, Tiffany F. Kautz, Godfrey Masette et autres
Abstract Background Over 60% of individuals with ADRDs live in low‐ and middle‐income countries (LMICs). Sub‐Saharan Africa (SSA) is projected to have the fastest growth in older adults, including people living with HIV (PLWH). Plasma ADRD biomarkers are promising diagnostic tools, but …
us, Ouganda, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Jennifer G Del Bosque, Chen‐Pin Wang, Roman Fernandez, Jeremy A. Tanner et autres
BACKGROUND: Hispanic adults comprise 19% of the US population, yet <8% of Alzheimer's Disease and Related Dementia (ADRD) research cohorts. Hispanic adults in the US are 1.5 times more likely to develop ADRDs compared to Non-Hispanics. Considering the projected growth in Hispanics …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Claudia L. Satizábal, Alexa Beiser, Alison M. Luckey, Rebecca Bernal et autres
Abstract Background Peak‐width of skeletonized mean diffusivity (PSMD) is an emerging biomarker of cerebral small vessel disease (cSVD)‐related vascular contributions to cognitive impairment and dementia (VCID). Higher PSMD values reflect greater white matter microstructural damage, and prior research has related PSMD to …
us, se, is
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Amaya M Seidl, Marco I Boisselier, Ashley LaRoche, Chen‐Pin Wang et autres
Abstract Background The Apolipoprotein E (APOE) ε4 variant is the strongest genetic risk factor for Alzheimer’s disease (AD) and has been thoroughly studied in non‐Hispanic whites (NHW). However, its association with AD among Hispanic individuals is unclear, with existing studies yielding mixed …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Janette Vazquez, Rebecca Bernal, Hector Trevino, Angel G. Velarde et autres
Abstract Background Vascular risk factors are known contributors to cognitive decline and dementia; however, their impact on cognitive change in diverse samples is understudied. In this study, we investigated the effect of the AHA Life’s Simple 7 (LS7) on cognitive decline in …
us
(code pays fourni par la source)