Multi Site Comparison of Participant Profiles in the South Texas Alzheimer’s Disease Research Center
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Le résumé fourni par la source
BACKGROUND: Hispanic adults comprise 19% of the US population, yet <8% of Alzheimer's Disease and Related Dementia (ADRD) research cohorts. Hispanic adults in the US are 1.5 times more likely to develop ADRDs compared to Non-Hispanics. Considering the projected growth in Hispanics in the US, a >400% increase in ADRDs in this population is anticipated over the next twenty-five years. Knowledge is limited on the prevalence and influence of social determinants of health (SDoH) and modifiable risk factors on cognition in ethnically diverse groups. The South Texas Alzheimer's Disease Research Center (STAC, P30AG066546) is a collaboration between UT Health San Antonio (UTHSA) and UT Rio Grande Valley (UTRGV) with a primary aim to better understand ADRDs in Hispanic adults. Our objective is (1) to describe differences in SDoH, modifiable risk factors, and cognitive performance in cognitively unimpaired adults in STAC, and (2) to assess differences between sites to better understand the risk factors in ADRDs in Hispanics by location. METHOD: Participants in San Antonio, Tx, and Rio Grande Valley, Tx completed cognitive testing and questionnaires of medical history, SDoH, and modifiable ADRD risk factors. The two sites were compared between sites with Wilcoxon and T-Tests. Differences in neurocognitive performance was further assessed with linear regression adjusting for age, sex, and education. RESULT: Cognitively unimpaired adults were enrolled at UTHSA (n = 180, mean(SD) age 71(10), 36% male, 47% Hispanic) and UTRGV (n = 45, age 63(12), 33% male, 71% Hispanic). Participants at UTRGV were younger and more frequently identified as Hispanic. Site differences were seen on Trails B (p < 0.001), and Number Span Total Forward (p = .001) and Total Backward (p = 0.009) after adjusting for age, sex, and education. Sites showed differences in risk factors including hyperlipidemia (p = <.001), hearing loss (p = .022), Sleep Apnea (p = .006), and alcohol use (p = .022). Other risk factors were similar across sites. CONCLUSION: Overall, there were significant differences in the risk factors between locations, supporting the value of recruiting participants at both sites to assess the spectrum of risk factors and SDoH in Hispanic adults.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multi Site Comparison of Participant Profiles in the South Texas Alzheimer’s Disease Research Center
- Date Crossref
- 01/12/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Texas at San Antonio Health Science Center pays non établi dans la noticeUniversité ou école supérieure
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Institute for Neurodegenerative Disorders pays non établi dans la noticeOrganisation à but non lucratif
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The University of Texas Health Science Center at Houston Glenn Biggs Institute for Alzheimer’s & pays non établi dans la noticeUniversité ou école supérieure
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The University of Texas at San Antonio pays non établi dans la noticeUniversité ou école supérieure
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Cedars-Sinai Medical Center pays non établi dans la noticeÉtablissement de santé
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The University of Texas Rio Grande Valley pays non établi dans la noticeUniversité ou école supérieure
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Glenn Biggs Institute for Alzheimer’s & pays non établi dans la noticeStructure de recherche
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UT Health San Antonio pays non établi dans la noticeInstitution
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University of Texas Health San Antonio Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases pays non établi dans la noticeUniversité ou école supérieure
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University of Texas Health Sciences Center at San Antonio Glenn Biggs Institute for Alzheimer’s & pays non établi dans la noticeUniversité ou école supérieure
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Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases pays non établi dans la noticeStructure de recherche
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Cedars‐Sinai Medical Center pays non établi dans la noticeÉtablissement de santé
The University of Texas at San Antonio Health Science Center, Institute for Neurodegenerative Disorders et Glenn Biggs Institute for Alzheimer’s & — The University of Texas Health Science Center at Houston, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.